Maternal exposure to titanium dioxide nanoparticles during pregnancy; impaired memory and decreased hippocampal cell proliferation in rat offspring

2014 ◽  
Vol 37 (2) ◽  
pp. 617-625 ◽  
Author(s):  
Abbas Mohammadipour ◽  
Alireza Fazel ◽  
Hossein Haghir ◽  
Fatemeh Motejaded ◽  
Houshang Rafatpanah ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Maternal Exposure ◽  
Rat Offspring ◽  
Impaired Memory ◽  
Hippocampal Cell

scholarly journals Internalization of Titanium Dioxide Nanoparticles Is Cytotoxic for H9c2 Rat Cardiomyoblasts

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1955 ◽  
Author(s):  
Elizabeth Huerta-García ◽  
Iván Zepeda-Quiroz ◽  
Helen Sánchez-Barrera ◽  
Zaira Colín-Val ◽  
Ernesto Alfaro-Moreno ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
Cell Death ◽  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Membrane Integrity ◽  
The Body ◽  
Potential Health ◽  
Tio2 Nps

Titanium dioxide nanoparticles (TiO2 NPs) are widely used in industry and daily life. TiO2 NPs can penetrate into the body, translocate from the lungs into the circulation and come into contact with cardiac cells. In this work, we evaluated the toxicity of TiO2 NPs on H9c2 rat cardiomyoblasts. Internalization of TiO2 NPs and their effect on cell proliferation, viability, oxidative stress and cell death were assessed, as well as cell cycle alterations. Cellular uptake of TiO2 NPs reduced metabolic activity and cell proliferation and increased oxidative stress by 19-fold measured as H2DCFDA oxidation. TiO2 NPs disrupted the plasmatic membrane integrity and decreased the mitochondrial membrane potential. These cytotoxic effects were related with changes in the distribution of cell cycle phases resulting in necrotic death and autophagy. These findings suggest that TiO2 NPs exposure represents a potential health risk, particularly in the development of cardiovascular diseases via oxidative stress and cell death.

The effects of exposure to titanium dioxide nanoparticles during lactation period on learning and memory of rat offspring

2013 ◽  
Vol 32 (2) ◽  
pp. 221-228 ◽  
Author(s):  
Abbas Mohammadipour ◽  
Mahmoud Hosseini ◽  
Alireza Fazel ◽  
Hossein Haghir ◽  
Houshang Rafatpanah ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Learning And Memory ◽  
Titanium Dioxide Nanoparticles ◽  
Lactation Period ◽  
Rat Offspring

scholarly journals EGF Conjugation Improves Safety and Uptake Efficacy of Titanium Dioxide Nanoparticles

Molecules ◽  
2020 ◽  
Vol 25 (19) ◽  
pp. 4467
Author(s):  
Basma Salama ◽  
Chia-Jung Chang ◽  
Koki Kanehira ◽  
El-Said El-Sherbini ◽  
Gehad El-Sayed ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Titanium Dioxide ◽  
Cellular Uptake ◽  
Cellular Proliferation ◽  
Titanium Dioxide Nanoparticles ◽  
Cancer Cell Line ◽  
Photodynamic Diagnosis ◽  
A431 Cells ◽  
Tio2 Nps ◽  
Epidermal Growth

Titanium dioxide nanoparticles (TiO2 NPs) have a strong potential for cancer therapeutic and bioimaging applications such as photodynamic therapy (PDT) and photodynamic diagnosis (PDD). Our previous results have shown that TiO2 NPs have a low cellular uptake and can induce cell proliferation. This suggests that TiO2 NPs could increase the risk of tumor overgrowth while being used for PDD and PDT. To solve this problem, we constructed epidermal growth factor-ligated polyethylene glycol-coated TiO2 NPs (EGF-TiO2 PEG NPs). In this work, we studied the effect of EGF conjugation on the cellular uptake of TiO2 PEG NPs. Then, we investigated the effect of both non-conjugated and EGF-TiO2 PEG NPs on the A431 epidermal cancer cell line, proliferation and growth via the investigation of EGFR localization and expression. Our results indicated that TiO2 PEG NPs induced EGFRs aggregation on the A431 cells surface and induced cell proliferation. In addition, EGF-TiO2 PEG NPs induced the internalization of EGFRs inside of cells with increased cellular NPs uptake and decreased cellular proliferation compared to TiO2 PEG NPs-treated cells. These findings suggest that EGF conjugation can increase the efficacy of TiO2 PEG NPs for biomedical applications such as PDD and PDT with decreased risk of tumor overgrowth.

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