Acute, sub-acute and general pharmacological evaluation of 5-(3,4-methylenedioxyphenyl)-4-ethyl-2E,4E-pentadienoic acid piperidide (SK-20): A novel drug bioavailability enhancer

2013 ◽  
Vol 35 (2) ◽  
pp. 347-359 ◽  
Author(s):  
Sheikh Rayees ◽  
Rohit Sharma ◽  
Gurdarshan Singh ◽  
Ishtiyaq Ahmad Najar ◽  
Amarinder Singh ◽  
...  
Keyword(s):  
Drug Bioavailability ◽  
Pharmacological Evaluation ◽  
Pentadienoic Acid ◽  
Novel Drug

scholarly journals Solid Lipid Nanoparticles: A Brief Review

2021 ◽  
pp. 368-385
Author(s):  
Amol Giri ◽  
Aijaz Sheikh ◽  
P R Tathe ◽  
G R Sitaphale ◽  
K R Biyani
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Surfactant Solution ◽  
Lipid Nanoparticles ◽  
Drug Bioavailability ◽  
New Approach ◽  
Pharmaceutical Ingredients ◽  
Advantages And Disadvantages ◽  
Solid Lipid ◽  
Novel Drug

In this present review this new approach of solid lipid Nanoparticles (SLNs) is discussed in terms of their aims, advantages, and disadvantages, methods of preparation, characterization and special features. In the state of developments in the research and development of new drug delivery systems have been made in Last decade by resolving various disorders, such as Low Drug Bioavailability and unpredictable gastric emptying era. Most of the active pharmaceutical ingredients are under poor bioavailability and also their solubility. By using the nanotechnology to overcome this problems of novel drug delivery system. The main advantage of nanotechnology i.e. solid lipid Nanoparticles increases the bioavailability and elimination biological half-life of the drugs. Solid lipid Nanoparticles are spherical lipid particles ranging in size from 1 to 1000 nm and are dispersed in water or in aqueous surfactant solution.

scholarly journals Role of Novel Drug Delivery Systems in Bioavailability Enhancement: At A Glance

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Mehta Abhinav ◽  
Jain Neha ◽  
Grobler Anne ◽  
Vandana Bharti
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Systemic Circulation ◽  
Delivery Systems ◽  
New Drugs ◽  
Target Tissue ◽  
Drug Bioavailability ◽  
Bioavailability Enhancement ◽  
Advantages And Disadvantages ◽  
Novel Drug

Novel drug delivery systems (NDDS) are one of the most strategies which enable to overcome the problems related to drug bioavailability. It is the rate and extent to which a drug becomes available to the target tissue after its administration. Most of the new drugs used today have poor bioavailability and are required to be administered at higher doses because only a small fraction of the administered dose is absorbed in the systemic circulation and able to reach the target site. This results in the wastage of major amount of drug and lead to adverse effects. Pharmaceutical technology mainly focuses on enhancing the solubility and permeability of drugs with lower bioavailability. Nanotechnology is the concept used in NDDS that enables a weight reduction of drug particles accompanied by an increase in stability and improved functionality. Various approaches such as nanosuspensions, liposomes, niosomes, nanoemulsions, cubosomes, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), cyclodextrins, phytosome etc., are used for the enhancement of bioavailability. The present review focuses on the different approaches used for bioavailability enhancement along with their advantages and disadvantages.

scholarly journals Advances in Oral Drug Delivery

2021 ◽  
Vol 12 ◽  
Author(s):  
Mohammed S. Alqahtani ◽  
Mohsin Kazi ◽  
Mohammad A. Alsenaidy ◽  
Muhammad Z. Ahmad
Keyword(s):  
Drug Delivery ◽  
Drug Administration ◽  
Drug Absorption ◽  
Oral Drug Delivery ◽  
Oral Route ◽  
Oral Drug ◽  
Drug Bioavailability ◽  
Oral Drug Absorption ◽  
Mucosal Permeability ◽  
Novel Drug

The oral route is the most common route for drug administration. It is the most preferred route, due to its advantages, such as non-invasiveness, patient compliance and convenience of drug administration. Various factors govern oral drug absorption including drug solubility, mucosal permeability, and stability in the gastrointestinal tract environment. Attempts to overcome these factors have focused on understanding the physicochemical, biochemical, metabolic and biological barriers which limit the overall drug bioavailability. Different pharmaceutical technologies and drug delivery systems including nanocarriers, micelles, cyclodextrins and lipid-based carriers have been explored to enhance oral drug absorption. To this end, this review will discuss the physiological, and pharmaceutical barriers influencing drug bioavailability for the oral route of administration, as well as the conventional and novel drug delivery strategies. The challenges and development aspects of pediatric formulations will also be addressed.

scholarly journals Supercritical Fluids as a State-of-the-Art Formulation Method of Nanoparticles for Ocular Drug Delivery

2021 ◽  
pp. 9-20
Author(s):  
Naida Omerović ◽  
Edina Vranić
Keyword(s):  
Drug Delivery ◽  
Supercritical Fluid ◽  
Supercritical Fluids ◽  
State Of The Art ◽  
Dosage Forms ◽  
Ocular Drug Delivery ◽  
Additional Benefit ◽  
Full Potential ◽  
Drug Bioavailability ◽  
Novel Drug

Conventional ophthalmic dosage forms, although being simple to apply and presenting great patients' compliance, display poorer drug bioavailability and retention time on the eye surface. To cope with these problems, one must formulate novel drug delivery systems, such as nanosystems, for ocular drug delivery. Different formulation methods of nanoparticles have been developed, but some of them, such as the supercritical fluid method, have not reached their full potential in ocular drug delivery. This article aims to present the possibilities of the supercritical fluid method when preparing nanosystems for ocular drug delivery. This method could be used more frequently and efficiently because it is environmentally friendly and produces nanoparticles of the desired physicochemical properties, which is especially important in ocular drug delivery considering its peculiarities. Modifications of the supercritical fluid method can be used when a drug has some specific properties, which is an additional benefit in ocular drug delivery.

Targeting Cancer using Curcumin Encapsulated Vesicular Drug Delivery Systems

2020 ◽  
Vol 26 ◽  
Author(s):  
Joel Hardwick ◽  
Jack Taylor ◽  
Meenu Mehta ◽  
Saurabh Satija ◽  
Keshav R. Paudel ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Therapeutic Potential ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Limiting Factors ◽  
Drug Bioavailability ◽  
Pharmacokinetic Properties ◽  
Anti Oxidant ◽  
Novel Drug

: Curcumin is a major curcuminoid present in turmeric. The compound is attributed with various therapeutic properties, which include, anti-oxidant, anti-inflammatory, anti-bacterial, anti-malarial, and neuroprotection. Due to its therapeutic potential, curcumin has been employed for centuries in treating different ailments. Curcumin has been investigated lately as a novel therapeutic agent in the treatment of cancer. However, the mechanisms by which curcumin exerts its cytotoxic effects on malignant cells are still not fully understood. One of the main limiting factors in the clinical use of curcumin is its poor bioavailability and rapid elimination. Advancements in drug delivery systems such as, nanoparticle based vesicular drug delivery platforms have improved several parameters, namely, drug bioavailability, solubility, stability, and controlled release properties. The use of curcumin-encapsulated niosomes to improve the physical and pharmacokinetic properties of curcumin is one such approach. This review provides an up-to-date summary on nanoparticle based vesicular drug carriers and their therapeutic applications. Specifically, we focus on niosomes as novel drug delivery formulations and their potential in improving the delivery of challenging small molecules, including curcumin. Overall, the applications of such carriers will provide a new direction for novel pharmaceutical drug delivery, as well as, biotechnology, nutraceutical, and functional food industries.

scholarly journals NOVEL DRUG DELIVERY SYSTEM THROUGH NASAL (NON-INVASIVE)

2018 ◽  
Vol 11 ◽  
Author(s):  
Ramachandran S
Keyword(s):  
Drug Delivery ◽  
Drug Administration ◽  
Nasal Administration ◽  
Therapeutic Effects ◽  
Nasal Drug Delivery ◽  
Drug Bioavailability ◽  
Pharmaceutical Dosage Forms ◽  
Nasal Sprays ◽  
Nasal Route ◽  
Novel Drug

Intranasal route is the best method for high absorption and direct delivery to the brain. The interests and importance, of this route, are that the systemic effects of drugs when administered through the nasal route, have expanded over recent decades and it used for therapeutic and recreational purposes. In comparison with the parenteral route of drug administration, intra-nasal administration of drugs offers an interesting alternative for achieving systemic therapeutic effects of drugs. The oral administration of the drug produces low drug bioavailability, and this can be minimized using this nasal route. Moreover, the advantage of this route is that it can bypass the first-pass metabolism. Therefore, it is important to understand the potential and limitations of various nasal drug delivery systems. The aim of this review article is to discuss the various pharmaceutical dosage forms that have the potential to be utilized for local or systemic drug administration. It is assumingly expected that this review will help to understand about this route and also to develop suitable intra-nasal formulations to achieve specific therapeutic objectives. The different types of nasal drug formulations that can be used are nasal drops, nasal sprays, nasal gels, nasal suspensions and emulsion, and nasal powders.

Nanoparticulate Drug Delivery System

2021 ◽  
pp. 173-185
Author(s):  
Akshada Bakliwal ◽  
Swati Gokul Talele ◽  
Shweta Shaileshkumar Gedam ◽  
Vijay Sharadkumar Chudiwal ◽  
Swapnil Sharadkumar Jain
Keyword(s):  
Drug Delivery ◽  
Patient Compliance ◽  
Drug Delivery Systems ◽  
Herbal Medicines ◽  
Delivery Systems ◽  
Drug Bioavailability ◽  
Therapeutic Value ◽  
Ancient Times ◽  
Novel Drug ◽  
Improve Patient

The herbal medicines have been extensively used worldwide since ancient times and have been accepted by physicians and patients for their improved therapeutic value as they have less adverse effects in contrast with modern medicines. Phytotherapeutics requires a scientific approach to carry the components in a sustained manner to increase patient compliance and to reduce the frequency of administration. This can be accomplished by designing novel drug delivery systems (NDDS) for herbal constituents. NDDSs not only reduce the frequency of drug administration to improve patient compliance but also help to enhance the therapeutic value by dropping toxicity and enhancing the drug bioavailability. A nanotechnology is a new approach in which nano-sized drug delivery systems of herbal drugs have a prospective future for enhancing the therapeutic activity and conquer problems associated with plant medicines. Hence, the addition of the nanotechnology as an NDDS in traditional medication is essential for the treatment of more chronic diseases like cancer, diabetes, asthma, and others.

scholarly journals Formulation, characterization and pharmacological evaluation of anti-inflammatory polyphyto matrix tablet as a novel drug delivery system

2016 ◽  
Vol 4 (03) ◽  
pp. 50-57
Author(s):  
Harikesh Maurya ◽  
Tirath Kumar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Matrix Tablet ◽  
Matrix Formulation ◽  
Standard Drug ◽  
Pharmacological Evaluation ◽  
Novel Drug Delivery System ◽  
Anti Inflammatory ◽  
Novel Drug

Objective: To deal with the formulation, characterization and pharmacological evaluation of anti-inflammatory polyphyto matrix tablet containing Carica papaya, Vitex negundo, Moringa oleifera and Boswellia serrata used as a novel drug delivery system. An attempt has been made to develop polyphyto matrix tablets by using HPMC and ethyl cellulose. Methods: Pharmacological screening of polyphyto matrix tablet was evaluated by using the carrageenan-induced paw edema rat model and the study carried out by using various doses (100, 200 and 300 mg/kg body weight) of three different polyphyto matrix formulations. Diclofenac sodium was used as a standard drug, due to its considerable report on antiinflammatory importance. Data were expressed by mean±SD; statistical analysis was performed by using ANOVA and p less than 0.05 considered as statistically significant. Results: Physical and chemical evaluation parameters of polyphyto matrix formulation exhibits potent and dose-dependent anti-inflammatory activity in all the tested animal groups. Formulation F1 significantly (p less than 0.05) suppresses the inflammation in the rat paw and found to be preeminent and stable in comparison with standard and other two (F2 and F3) formulations. Conclusion: Study reveals that the polyphyto matrix formulation could be useful as either an alternative or a complementary therapy in the management of all types of inflammation. It may be due to presence of terpenoids, alkaloids, glycosides and other phytochemical in herbs.

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