A comprehensive re-analysis of pesticide dermal toxicity data in birds and comparison with the rat

2012 ◽  
Vol 34 (2) ◽  
pp. 416-427 ◽  
Author(s):  
Pierre Mineau
Keyword(s):  
Toxicity Data ◽  
Dermal Toxicity

Nature and Origin of Micropollutants

1982 ◽  
Vol 14 (12) ◽  
pp. 5-14 ◽  
Author(s):  
D Mackay
Keyword(s):  
Adverse Effects ◽  
Toxicity Data ◽  
Low Level ◽  
Environmental Models ◽  
Toxic Event ◽  
And Control

The origins of “micropollutants” are discussed and classified. It is suggested that assessing the risk and ensuring an acceptably low level of adverse effects from these substances requires information or control of three factors (exposure, toxicity and characteristics of the victim or organism) which combine to generate the toxic event. Methods of estimating exposure are discussed, especially environmental models. Ultimately, it should be possible to couple these models to toxicity data in a rational, rigorous manner to elucidate the extent of risk and control it to acceptable levels.

Marine Quality Standards: Their Derivation and Application in the United Kingdom

1985 ◽  
Vol 17 (6-7) ◽  
pp. 1187-1198 ◽  
Author(s):  
G. Mance ◽  
A. R. O'Donnell
Keyword(s):  
Coastal Waters ◽  
Sublethal Effects ◽  
Quality Standards ◽  
Toxicity Data ◽  
Marine Life ◽  
Nickel Zinc ◽  
The United Kingdom ◽  
The Common ◽  
Lead Nickel ◽  
The Impact

This paper discusses the derivation of environmental quality standards for coastal waters and the difficulties of using such standards for controlling industrial discharges. Attention is focused on the common List II substances, copper, chromium, lead, nickel, zinc and arsenic - and their effects on marine life. The adequacy of existing toxicity data is discussed and it is concluded that long exposure tests are required to provide information on sublethal effects. Such data are currently limited. It is also important that consideration be given to the effects that reducing salinities and increasing temperatures have in increasing the toxicity of these substances. The complexity of interpreting the results of laboratory toxicity data to coastal waters is discussed with reference to a study of the impact of an industrial discharge.

A New Approach for the Analysis of Mixture Toxicity Data

1992 ◽  
Vol 26 (9-11) ◽  
pp. 2345-2348 ◽  
Author(s):  
C. N. Haas
Keyword(s):  
Quantitative Analysis ◽  
Mixture Toxicity ◽  
New Method ◽  
Metal Exposure ◽  
Positive Interactions ◽  
Toxicity Data ◽  
Data Set ◽  
New Approach ◽  
Negative Interactions

A new method for the quantitative analysis of multiple toxicity data is described and illustrated using a data set on metal exposure to copepods. Positive interactions are observed for Ni-Pb and Pb-Cr, with weak negative interactions observed for Ni-Cr.

Formulating biossay data of chemicals and environmental water

2000 ◽  
Vol 42 (3-4) ◽  
pp. 115-123 ◽  
Author(s):  
R. Shoji ◽  
A. Sakoda ◽  
Y. Sakai ◽  
M. Suzuki
Keyword(s):  
Water Quality ◽  
Low Density Lipoprotein ◽  
Water Environment ◽  
Density Lipoprotein ◽  
Environmental Water ◽  
Toxicity Data ◽  
Human Beings ◽  
Environmental Waters ◽  
Bodies Of Water

The quality of environmental waters such as rivers is often deteriorated by various kinds of trace and unidentified chemicals despite the recent development of sewage systems and wastewater treatment technologies. In addition to contamination by particular toxicants, complex toxicity due to multi-component chemicals could be much more serious. The environmental situation in bodies of water in Japan led us to apply bioassays for monitoring the water quality of environmental waters in order to express the direct and potential toxicity to human beings and ecosystems rather than determinating concentrations of particular chemicals. However, problems arose from the fact that bioassays for pharmaceutical purposes generally required complicated, time-consuming, expert procedures. Also, a methodology for feedback of the resultant toxicity data to water environment management has not been established yet. To this end, we developed a novel bioassay based on the low-density lipoprotein (LDL) uptake activity of human hepatoblastoma cells. The assay enabled us to directly detect the toxicity of environmental waters within 4 hours of exposure. This is a significantly quick and easy procedure as compared to that of conventional bioassays. The toxicity data for 255 selected chemicals and environmental waters obtained by this method were organized by a mathematical equation in order to make those data much more effectively and practically useful to the management of environmental waters. Our methodology represents a promising example of applying bioassays to monitor environmental water quality and generating potential solutions to the toxicity problems encountered.

The Development and Evaluation of In Vitro Tests by the FRAME Alternatives Laboratory

1995 ◽  
Vol 23 (1) ◽  
pp. 75-90
Author(s):  
Richard H. Clothier ◽  
Karen A. Atkinson ◽  
Michael J. Garle ◽  
Rachel K. Ward ◽  
Angela Willshaw
Keyword(s):  
Research Programme ◽  
Neutral Red ◽  
In Vitro Cytotoxicity ◽  
In Vitro Tests ◽  
Dermal Toxicity ◽  
Mechanisms Of Toxicity ◽  
The Us ◽  
Detergent Association ◽  
Assay Methods

This review outlines the work which has been conducted in the FRAME Alternatives Laboratory during the first ten years of the FRAME Research Programme. A number of in vitro tests, including the kenacid blue, neutral red release and fluorescein leakage assay methods, have been evaluated and have subsequently been included in validation schemes organised by the US Soap and Detergent Association, the US Cosmetic, Toiletry and Fragrance Association, the European Commission and the European Cosmetic, Toiletry and Perfumery Association, as well as in the Scandinavian multicentre evaluation of in vitro cytotoxicity testing scheme. More recently, research has been undertaken in the areas of phototoxicity, immunotoxicity, dermal toxicity and intercellular communication, in addition to investigations into fundamental mechanisms of toxicity.

scholarly journals Environmental Risk of Pesticides for Fish in Small- and Medium-Sized Streams of Switzerland

Toxics ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 79
Author(s):  
Inge Werner ◽  
Anke Schneeweiss ◽  
Helmut Segner ◽  
Marion Junghans
Keyword(s):  
Life History Traits ◽  
Sublethal Effects ◽  
Toxicity Data ◽  
Laboratory Studies ◽  
Fish Health ◽  
Model Species ◽  
Pyrethroid Insecticides ◽  
Relative Contribution ◽  
Single Substance ◽  
Chronic Risk

This study assessed the acute and chronic risk of pesticides, singly and as mixtures, for fish using comprehensive chemical data of four monitoring studies conducted in small- and medium-sized streams of Switzerland between 2012 and 2018. Pesticides were ranked based on single substance risk quotients and relative contribution to mixture risk. Concentrations of the pyrethroid insecticides, λ-cyhalothrin, cypermethrin and deltamethrin, and the fungicides, carbendazim and fenpropimorph, posed acute or chronic single substance risks. Risk quotients of eighteen additional pesticides were equal or greater than 0.1, and thirteen of those contributed ≥30% to mixture risk. Relatively few substances dominated the mixture risk in most water samples, with chronic and acute maximum cumulative ratios never exceeding 5 and 7, respectively. A literature review of toxicity data showed that concentrations of several pesticides detected in Swiss streams were sufficient to cause direct sublethal effects on fish in laboratory studies. Based on the results of our study, we conclude that pesticides detected in Swiss streams, especially pyrethroid insecticides, fungicides and pesticide mixtures, pose a risk to fish health and can cause direct sublethal effects at environmental concentrations. Sensitive life stages of species with highly specialized life history traits may be particularly vulnerable; however, the lack of toxicity data for non-model species currently prevents a conclusive assessment across species.

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