Protective effect of caffeic acid phenethyl ester (CAPE) on fluoride-induced oxidative stress and apoptosis in rat endometrium

2007 ◽  
Vol 24 (2) ◽  
pp. 86-91 ◽  
Author(s):  
Mehmet Guney ◽  
Baha Oral ◽  
Nermin Karahan ◽  
Tamer Mungan
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester

Protective effect of Caffeic Acid Phenethyl Ester (CAPE) against oxidative stress

2017 ◽  
Vol 29 ◽  
pp. 178-184 ◽  
Author(s):  
Ana Laura Carreño ◽  
Efrain Alday ◽  
Jael Quintero ◽  
Lucía Pérez ◽  
Dora Valencia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester

scholarly journals Protective Effect of Caffeic Acid Phenethyl Ester on Antituberculosis Drug-Induced Hepatotoxicity in Rats

2018 ◽  
Vol 102 (9-10) ◽  
pp. 473-478 ◽  
Author(s):  
Cigdem Aliosmanoglu ◽  
Halil Erbiş ◽  
Ibrahim Aliosmanoglu ◽  
Mehmet Akif Türkoglu ◽  
Burak Veli Ulger ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Trace Elements ◽  
Protective Effect ◽  
Caffeic Acid ◽  
Liver Function Tests ◽  
Caffeic Acid Phenethyl Ester ◽  
Stress Index ◽  
Albino Rats ◽  
Drug Induced ◽  
Antituberculosis Treatment

Isoniazid and rifampicin are drugs primarily used in antituberculosis treatment. Our aim in this study is to evaluate the effect of caffeic acid phenethyl ester's protective effect on liver function tests and to trace elements in hepatic damage caused by isoniazid and rifampicin on rats. Forty Wistar albino rats were divided into 4 groups. Group 1: Sham, Group 2: caffeic acid phenethyl ester application, Group 3: isoniazid and rifampicin given, Group 4: isoniazid + rifampicin and caffeic acid phenethyl ester application. After 30 days, the rats were sacrificed by taking blood from the heart. Alanine aminotransferase, aspartate aminotransferase, zinc, copper, total antioxidant capacity, total oxidative status, and oxidative stress index levels were evaluated. The rats to which isoniazid + rifampicin+ caffeic acid phenethyl ester were given had less oxidative stress and copper levels (P < 0.001, P = 0.019) but have higher zinc levels (P = 0.001) compared to the isoniazid + rifampicin group. Liver enzyme levels were also lower in rats that were given isoniazid + rifampicin + caffeic acid phenethyl ester (P < 0.001). The results of this study suggested that caffeic acid phenethyl ester influences the levels of trace elements (copper and zinc) that are important for the physiologic mechanisms of organisms, reducing liver damage.

Protective Effect of Caffeic Acid Phenethyl Ester on Oxidative Stress in Diabetic Rat Sciatic Nerve

2012 ◽  
Vol 8 (6) ◽  
pp. 577-581 ◽  
Author(s):  
Yavuz Yucel ◽  
Tahsin Celepkolu ◽  
Erkan Kibrisli ◽  
Faruk Kilinc ◽  
Coskun Beyaz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sciatic Nerve ◽  
Protective Effect ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Diabetic Rat ◽  
Rat Sciatic Nerve

scholarly journals Caffeic Acid - Potential Antioxidant in Cultured Human Retinal Pigment Epithelial Cells

1970 ◽  
Vol 66 (2) ◽  
Author(s):  
Dumitriţa RUGINǍ ◽  
Adela PINTEA ◽  
Raluca PÂRLOG ◽  
Andreea VARGA
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Protective Effect ◽  
Caffeic Acid ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Antioxidant Defence ◽  
Rpe Cells ◽  
In Cells

Oxidative stress causes biological changes responsible for carcinogenesis and aging in human cells. The retinal pigmented epithelium is continuously exposed to oxidative stress. Therefore reactive oxygen species (ROS) and products of lipid peroxidation accumulate in RPE. Neutralization of ROS occurs in retina by the action of antioxidant defence systems. In the present study, the protective effect of caffeic acid (3,4-dihydroxy cinnamic acid), a dietary phenolic compound, has been examined in normal and in oxidative stress conditions (500 µM peroxide oxygen) in cultures human epithelial pigment retinal cells (Nowak, M. et al.). The cell viability, the antioxidant enzymes activity (CAT, GPx, SOD) and the level of intracellular reactive oxygen species (ROS) were determined. Exposure to l00 µM caffeic acid for 24 h induced cellular changes indicating the protective effect of caffeic acid in RPE cells. Caffeic acid did not show any cytotoxic effect at concentrations lower than 200 μM in culture medium. Treatment of RPE cells with caffeic acid causes an increase of catalase, glutathione peroxidase and superoxide dismutase activity, especially in cells treated with hydrogen peroxide. Caffeic acid causes a decrease of ROS level in cells treated with hydrogen peroxide. This study proved that caffeic acid or food that contain high levels of this phenolic acid may have beneficial effects in prevention of retinal diseases associated with oxidative stress by improving antioxidant defence systems.

scholarly journals Research on the protective effect of caffeic acid phenethyl ester on testicular damage caused by cisplatin

2020 ◽  
Vol 50 (8) ◽  
pp. 2032-2039
Author(s):  
Tayfun CEYLAN ◽  
Emin KAYMAK ◽  
Fazile CANTÜRK ◽  
Birkan YAKAN
Keyword(s):  
Protective Effect ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Testicular Damage

scholarly journals Caffeic acid phenethyl ester protects against oxidative stress and dampens inflammation via heme oxygenase 1

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Alexandra Stähli ◽  
Ceeneena Ubaidha Maheen ◽  
Franz Josef Strauss ◽  
Sigrun Eick ◽  
Anton Sculean ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Caffeic Acid ◽  
Heme Oxygenase ◽  
Caffeic Acid Phenethyl Ester ◽  
Heme Oxygenase 1
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