scholarly journals Hybrid penicillin acylases with improved properties for synthesis of β-lactam antibiotics

2007 ◽  
Vol 40 (5) ◽  
pp. 1335-1344 ◽  
Author(s):  
Simon A.W. Jager ◽  
Peter A. Jekel ◽  
Dick B. Janssen
Keyword(s):  
Penicillin Acylases

scholarly journals Structure mediation in substrate binding and post-translational processing of penicillin acylases: Information from mutant structures ofKluyvera citrophilapenicillin G acylase

2015 ◽  
Vol 24 (10) ◽  
pp. 1660-1670 ◽  
Author(s):  
Deepak Chand ◽  
NishantKumar Varshney ◽  
Sureshkumar Ramasamy ◽  
Priyabrata Panigrahi ◽  
James A. Brannigan ◽  
...  
Keyword(s):  
Substrate Binding ◽  
Penicillin Acylases

scholarly journals Studying the Possibilities of Using 2-Halogen-Substituted Acetamides As Acyl Donors in Penicillin Acylase-Catalyzed Reactions

Acta Naturae ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 77-81
Author(s):  
N. V. Panin ◽  
M. V. Nikulin ◽  
E. S. Tiurin ◽  
V. V. Drobot ◽  
I. A. Morozova ◽  
...  
Keyword(s):  
Alcaligenes Faecalis ◽  
Penicillin Acylase ◽  
Enzyme Inactivation ◽  
Acyl Donor ◽  
Negative Contribution ◽  
Catalyzed Reactions ◽  
The Impact ◽  
Acyl Donors ◽  
Penicillin Acylases ◽  
Acetic Acids

The possibility of using amides of halogen-substituted acetic acids as acyl donors in penicillin acylase-catalyzed reactions has been investigated, and the ability of this group of compounds to inactivate enzymes in the course of the catalytic conversion has been established. The strongest inactivating effect was demonstrated by iodoacetamide and bromoacetamide. However, the negative contribution of this side activity can be minimized by decreasing the temperature, when the rate of acyl donor conversion by penicillin acylases is still high enough, but the impact of enzyme inactivation becomes less significant. The catalytic activity of penicillin acylase from Alcaligenes faecalis in the conversion of 2-haloacetamides was significantly (5-8 times) higher than that of penicillin acylase from Escherichia coli.

scholarly journals The Use of Chromogenic Reference Substrates for the Kinetic Analysis of Penicillin Acylases

1999 ◽  
Vol 275 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Wynand B.L. Alkema ◽  
René Floris ◽  
Dick B. Janssen
Keyword(s):  
Kinetic Analysis ◽  
Penicillin Acylases

Penicillin acylases

1984 ◽  
Vol 9 (5-6) ◽  
pp. 537-554 ◽  
Author(s):  
Pramod B. Mahajan
Keyword(s):  
Penicillin Acylases

Penicillin Acylases

2007 ◽  
pp. 583-597 ◽  
Author(s):  
David W. Spence ◽  
Martin Ramsden
Keyword(s):  
Penicillin Acylases

Penicillin acylases revisited: importance beyond their industrial utility

2014 ◽  
Vol 36 (2) ◽  
pp. 303-316 ◽  
Author(s):  
Vellore Sunder Avinash ◽  
Archana Vishnu Pundle ◽  
Sureshkumar Ramasamy ◽  
Cheravakkattu Gopalan Suresh
Keyword(s):  
Penicillin Acylases

Biotechnological applications of penicillin acylases: state-of-the-art

2003 ◽  
Vol 60 (5) ◽  
pp. 507-514 ◽  
Author(s):  
M. Arroyo ◽  
I. de la Mata ◽  
C. Acebal ◽  
M. Pilar Castillón
Keyword(s):  
State Of The Art ◽  
Biotechnological Applications ◽  
Penicillin Acylases
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