Oxidative stress-mediated particulate matter affects the risk of relapse in schizophrenia patients: Air purification intervention-based panel study

2021 ◽  
pp. 118348
Author(s):  
Qiannan Wei ◽  
Yifu Ji ◽  
Hua Gao ◽  
Weizhuo Yi ◽  
Rubing Pan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Particulate Matter ◽  
Panel Study ◽  
Air Purification ◽  
Risk Of Relapse

scholarly journals Association of Particulate Matter from Cooking Oil Fumes with Heart Rate Variability and Oxidative Stress

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1323
Author(s):  
Chang-Chuan Chan ◽  
Lian-Yu Lin ◽  
Ching-Huang Lai ◽  
Kai-Jen Chuang ◽  
Ming-Tsang Wu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Particulate Matter ◽  
Stress Responses ◽  
Panel Study ◽  
Cooking Oil ◽  
Cooking Oil Fumes ◽  
Increased Risk ◽  
And Oxidative Stress

Many studies have reported various cardiovascular autonomic responses to ambient particulate matter (PM) pollution, but few have reported such responses to occupational PM exposures. Even fewer have demonstrated a relationship between PM pollution and oxidative stress in humans. This panel study evaluates the association between occupational exposure to PM in cooking oil fumes (COFs), and changes in both heart rate variability (HRV) and oxidative stress responses in 54 male Chinese cooks. Linear mixed-effects regression models were adopted to estimate the strength of the association between PM and HRV. Participants’ pre- and post-workshift urine samples were analyzed for 8-hydroxy-2′-deoxyguanosine (8-OHdG) and malondialdehyde (MDA). Exposure to PM in COFs from 15 min to 2 h were associated with a decrease in HRV and an increase in heart rate among cooks. The urinary 8-OHdG levels of cooks were significantly elevated after workshift exposure to COFs. The levels of PM2.5, PM1.0, and particulate benzo(a)pyrene in COFs were all positively correlated with cross-workshift urinary 8-OHdG levels. Furthermore, the levels of benzo(a)pyrene in COFs were positively correlated with cross-workshift urinary MDA levels. The effects of COFs on HRV were independent of cross-workshift urinary 8-OHdG levels. Exposure to COFs leads to disturbed autonomic function and an increased risk of oxidative DNA injury among cooks in Chinese restaurants.

Sign in / Sign up

Export Citation Format

Share Document