The interaction effects of polycyclic aromatic hydrocarbons exposure and TERT- CLPTM1L variants on longitudinal telomere length shortening: A prospective cohort study

2018 ◽  
Vol 242 ◽  
pp. 2100-2110 ◽  
Author(s):  
Wenshan Fu ◽  
Zhuowang Chen ◽  
Yansen Bai ◽  
Xiulong Wu ◽  
Guyanan Li ◽  
...  
Keyword(s):  
Cohort Study ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Telomere Length ◽  
Prospective Cohort Study ◽  
Aromatic Hydrocarbons ◽  
Prospective Cohort ◽  
Interaction Effects ◽  
Polycyclic Aromatic

Polycyclic aromatic hydrocarbons exposures and telomere length: A cross-sectional study on preschool children

2021 ◽  
Vol 195 ◽  
pp. 110757
Author(s):  
Abolfazl Adli ◽  
Seyed Mostafa Hosseini ◽  
Moslem Lari Najafi ◽  
Maryam Behmanesh ◽  
Elahe Ghezi ◽  
...  
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Preschool Children ◽  
Telomere Length ◽  
Aromatic Hydrocarbons ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Polycyclic Aromatic

scholarly journals Telomere length and depression: Prospective cohort study and Mendelian randomisation study in 67 306 individuals

2017 ◽  
Vol 210 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Marie Kim Wium-Andersen ◽  
David Dynnes Ørsted ◽  
Line Rode ◽  
Stig Egil Bojesen ◽  
Børge Grønne Nordestgaard
Keyword(s):  
Cohort Study ◽  
General Population ◽  
Telomere Length ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Antidepressant Medication ◽  
Mendelian Randomisation ◽  
Short Telomere ◽  
Genetic Analyses

BackgroundDepression has been cross-sectionally associated with short telomeres as a measure of biological age. However, the direction and nature of the association is currently unclear.AimsWe examined whether short telomere length is associated with depression cross-sectionally as well as prospectively and genetically.MethodTelomere length and three polymorphisms, TERT, TERC and OBFC1, were measured in 67306 individuals aged 20–100 years from the Danish general population and associated with register-based attendance at hospital for depression and purchase of antidepressant medication.ResultsAttendance at hospital for depression was associated with short telomere length cross-sectionally, but not prospectively. Further, purchase of antidepressant medication was not associated with short telomere length cross-sectionally or prospectively. Mean follow-up was 7.6 years (range 0.0–21.5). The genetic analyses suggested that telomere length was not causally associated with attendance at hospital for depression or with purchase of antidepressant medication.ConclusionsShort telomeres were not associated with depression in prospective or in causal, genetic analyses.

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