Mercury concentrations in human placenta, umbilical cord, cord blood and amniotic fluid and their relations with body parameters of newborns

2013 ◽  
Vol 182 ◽  
pp. 256-262 ◽  
Author(s):  
Iwona Kozikowska ◽  
Łukasz J. Binkowski ◽  
Katarzyna Szczepańska ◽  
Helena Sławska ◽  
Katarzyna Miszczuk ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Human Placenta ◽  
Body Parameters

scholarly journals Human Placenta-Derived Stem Cell S (HPDSC) Augment Transplantation with Umbilical Cord Blood

2009 ◽  
Vol 15 (2) ◽  
pp. 51
Author(s):  
L.C. Yu ◽  
H. Faleck ◽  
K. Johnson ◽  
D. Payne ◽  
R. Hariri
Keyword(s):  
Stem Cell ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Human Placenta

Measurement of CEA, TPA, Neopterin, CA125, CA153 and CA199 in Sera of Pregnant Women, Umbilical Cord Blood and Amniotic Fluid

1989 ◽  
Vol 27 (3) ◽  
pp. 137-142 ◽  
Author(s):  
Ralph J. Lellé ◽  
Eberhard Henkel ◽  
Dieter Leinemann ◽  
Klaus Goeschen
Keyword(s):  
Amniotic Fluid ◽  
Cord Blood ◽  
Pregnant Women ◽  
Umbilical Cord ◽  
Umbilical Cord Blood

scholarly journals Pro-opiomelanocortin in human pregnancy: evolution of maternal plasma levels, concentrations in cord blood, amniotic fluid and at the feto-maternal interface

2000 ◽  
pp. 53-59 ◽  
Author(s):  
ML Raffin-Sanson ◽  
F Ferre ◽  
J Coste ◽  
C Oliver ◽  
D Cabrol ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Cord Blood ◽  
Pregnant Women ◽  
Human Placenta ◽  
Plasma Levels ◽  
Maternal Blood ◽  
Prospective Longitudinal Study ◽  
Gestation Time ◽  
Prospective Longitudinal ◽  
Very High

OBJECTIVE: The human placenta normally expresses the pro-opiomelanocortin (POMC) gene. The pattern and secretory kinetics of POMC and/or POMC-derived peptides by the placenta during gestation is still debated. We recently demonstrated that full length POMC was a normal product of the human placenta. The aim of our study was to establish its normal secretory kinetics and to explore its physiological relevance. DESIGN: In a prospective, longitudinal study, thirty normal pregnant women had monthly measurements of plasma POMC. In a cross-sectional study of 128 healthy pregnant women, plasma POMC and human chorionic gonadotrophin (hCG) were concomitantly measured to assess their correlation. Finally, POMC levels were assessed in venous and arterial cord blood samples, in amniotic fluid and in retroplacental blood. METHODS: Plasma POMC was measured by a specific IRMA in unextracted blood or biological fluid. RESULTS: Plasma POMC became detectable by the 8th week of pregnancy and reached its maximum at around the 20th week, remaining stable thereafter. The relationship between POMC and gestation time (weeks) best fitted with a third degree polynomia curve. A significant negative correlation (P=0.01) was observed between plasma levels of POMC and hCG after adjustment for gestation time to take into account the dependence of both hormones on this parameter. POMC was not secreted into the fetal circulation at term, but was present in very high levels in amniotic fluid. The highest levels of POMC were present in the retroplacental blood where the values were 35 times higher than in maternal blood; by comparison, corticotrophin releasing hormone and ACTH values in this compartment were twice or equal to those in the maternal blood. CONCLUSION: Placental POMC secretion increases during the first half of pregnancy and reaches a plateau from the 20th week to delivery. The inverse correlation between POMC and hCG plasma levels, and very high POMC levels at the feto-maternal interface suggest a physiological role for this precursor during pregnancy.

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