Sub-toxic effects of CuO nanoparticles on bacteria: Kinetics, role of Cu ions and possible mechanisms of action

2012 ◽  
Vol 169 ◽  
pp. 81-89 ◽  
Author(s):  
Olesja Bondarenko ◽  
Angela Ivask ◽  
Aleksandr Käkinen ◽  
Anne Kahru
Keyword(s):  
Mechanisms Of Action ◽  
Cuo Nanoparticles ◽  
Toxic Effects ◽  
Cu Ions

Toxic Effects of Cypermethrin on Sperms and The Possible Protective Role of Vitamines C and E : An Invitro Study

2012 ◽  
Vol 20 (2) ◽  
pp. 101-119
Author(s):  
Sahar El-Dakroory ◽  
Amal El-Bakary ◽  
Adel Zalata ◽  
Hussien Abd Elaziz
Keyword(s):  
Protective Role ◽  
Toxic Effects

Autophagy Modulators and Neuroinflammation

2020 ◽  
Vol 27 (6) ◽  
pp. 955-982 ◽  
Author(s):  
Kyoung Sang Cho ◽  
Jang Ho Lee ◽  
Jeiwon Cho ◽  
Guang-Ho Cha ◽  
Gyun Jee Song
Keyword(s):  
Neurodegenerative Disorders ◽  
Neurological Disorders ◽  
Mammalian Cells ◽  
Critical Role ◽  
Therapeutic Agents ◽  
Mechanisms Of Action ◽  
Scientific Interest ◽  
Therapeutic Tools ◽  
Underlying Mechanisms

Background: Neuroinflammation plays a critical role in the development and progression of various neurological disorders. Therefore, various studies have focused on the development of neuroinflammation inhibitors as potential therapeutic tools. Recently, the involvement of autophagy in the regulation of neuroinflammation has drawn substantial scientific interest, and a growing number of studies support the role of impaired autophagy in the pathogenesis of common neurodegenerative disorders. Objective: The purpose of this article is to review recent research on the role of autophagy in controlling neuroinflammation. We focus on studies employing both mammalian cells and animal models to evaluate the ability of different autophagic modulators to regulate neuroinflammation. Methods: We have mostly reviewed recent studies reporting anti-neuroinflammatory properties of autophagy. We also briefly discussed a few studies showing that autophagy modulators activate neuroinflammation in certain conditions. Results: Recent studies report neuroprotective as well as anti-neuroinflammatory effects of autophagic modulators. We discuss the possible underlying mechanisms of action of these drugs and their potential limitations as therapeutic agents against neurological disorders. Conclusion: Autophagy activators are promising compounds for the treatment of neurological disorders involving neuroinflammation.

scholarly journals The Role of Oxidative Stress in NAFLD–NASH–HCC Transition—Focus on NADPH Oxidases

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 687
Author(s):  
Daniela Gabbia ◽  
Luana Cannella ◽  
Sara De De Martin
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Current Knowledge ◽  
Mechanisms Of Action ◽  
Nadph Oxidases ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

A peculiar role for oxidative stress in non-alcoholic fatty liver disease (NAFLD) and its transition to the inflammatory complication non-alcoholic steatohepatitis (NASH), as well as in its threatening evolution to hepatocellular carcinoma (HCC), is supported by numerous experimental and clinical studies. NADPH oxidases (NOXs) are enzymes producing reactive oxygen species (ROS), whose abundance in liver cells is closely related to inflammation and immune responses. Here, we reviewed recent findings regarding this topic, focusing on the role of NOXs in the different stages of fatty liver disease and describing the current knowledge about their mechanisms of action. We conclude that, although there is a consensus that NOX-produced ROS are toxic in non-neoplastic conditions due to their role in the inflammatory vicious cycle sustaining the transition of NAFLD to NASH, their effect is controversial in the neoplastic transition towards HCC. In this regard, there are indications of a differential effect of NOX isoforms, since NOX1 and NOX2 play a detrimental role, whereas increased NOX4 expression appears to be correlated with better HCC prognosis in some studies. Further studies are needed to fully unravel the mechanisms of action of NOXs and their relationships with the signaling pathways modulating steatosis and liver cancer development.

The critical role of light in moderating microbial stress due to mixtures of engineered nanomaterials

2018 ◽  
Vol 5 (1) ◽  
pp. 96-102 ◽  
Author(s):  
Carolyn M. Wilke ◽  
Jean-François Gaillard ◽  
Kimberly A. Gray
Keyword(s):  
Critical Role ◽  
Engineered Nanomaterials ◽  
Metal Nanoparticle ◽  
Toxic Effects ◽  
Solar Irradiation ◽  
Localized Surface Plasmon ◽  
E Coli ◽  
Simulated Solar Irradiation ◽  
Role Of Light

Light influences chemical interactions of engineered nanomaterials and their toxic effects. Under simulated solar irradiation, we observed that binary mixtures of n-Ag, n-Au, or n-Pt with n-TiO2cause synergistic toxic effects inE. colidue to photochemical interactions governed by metal nanoparticle stability and localized surface plasmon resonance.

scholarly journals Microbiome—Friend or Foe of Pancreatic Cancer?

2021 ◽  
Vol 10 (23) ◽  
pp. 5624
Author(s):  
Jaroslaw Daniluk ◽  
Urszula Daniluk ◽  
Pawel Rogalski ◽  
Andrzej Dabrowski ◽  
Agnieszka Swidnicka-Siergiejko
Keyword(s):  
Pancreatic Cancer ◽  
Treatment Effectiveness ◽  
Human Microbiome ◽  
Mechanisms Of Action ◽  
Ductal Adenocarcinoma ◽  
Overall Survival Rate ◽  
Improve Treatment ◽  
Potential Marker ◽  
Deadly Disease

Pancreatic ductal adenocarcinoma is one of the deadliest human neoplasms. Despite the development of new surgical and adjuvant therapies, the prognosis remains very poor, with the overall survival rate not exceeding 9%. There is now increasing evidence that the human microbiome, which is involved in many physiological functions, including the regulation of metabolic processes and the modulation of the immune system, is possibly linked to pancreatic oncogenesis. However, the exact mechanisms of action are poorly understood. Our review summarizes the current understanding of how the microbiome affects pancreatic cancer development and progression. We discuss potential pathways of microbe translocation to the pancreas, as well as the mechanism of their action. We describe the role of the microbiome as a potential marker of pancreatic cancer diagnosis, progression, and survival. Finally, we discuss the possibilities of modifying the microbiome to improve treatment effectiveness for this deadly disease.

scholarly journals Role of vitamin C on protection against toxic effects of cadmium

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Skender Sopi ◽  
Feim Masurica ◽  
Seit Bozo
Keyword(s):  
Vitamin C ◽  
Toxic Effects
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