Ionizing radiation-induced DNA damage response identified in marine mussels, Mytilus sp.

2012 ◽  
Vol 168 ◽  
pp. 107-112 ◽  
Author(s):  
Ohoud D. AlAmri ◽  
Andrew B. Cundy ◽  
Yanan Di ◽  
Awadhesh N. Jha ◽  
Jeanette M. Rotchell
Keyword(s):  
Dna Damage ◽  
Ionizing Radiation ◽  
Dna Damage Response ◽  
Damage Response ◽  
Marine Mussels ◽  
Radiation Induced

scholarly journals Acetylation dynamics of human nuclear proteins during the ionizing radiation-induced DNA damage response

Cell Cycle ◽  
2013 ◽  
Vol 12 (11) ◽  
pp. 1688-1695 ◽  
Author(s):  
Martin Bennetzen ◽  
Dorthe Larsen ◽  
Christoffel Dinant ◽  
Sugiko Watanabe ◽  
Jiri Bartek ◽  
...  
Keyword(s):  
Dna Damage ◽  
Ionizing Radiation ◽  
Dna Damage Response ◽  
Nuclear Proteins ◽  
Damage Response ◽  
Radiation Induced

scholarly journals Regulation of DNA Damage Response and Homologous Recombination Repair by microRNA in Human Cells Exposed to Ionizing Radiation

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1838
Author(s):  
Magdalena Szatkowska ◽  
Renata Krupa
Keyword(s):  
Dna Damage ◽  
Homologous Recombination ◽  
Ionizing Radiation ◽  
Dna Damage Response ◽  
Cell Response ◽  
Dna Lesions ◽  
Homologous Recombination Repair ◽  
Recombination Repair ◽  
Damage Response ◽  
Radiation Induced

Ionizing radiation may be of both artificial and natural origin and causes cellular damage in living organisms. Radioactive isotopes have been used significantly in cancer therapy for many years. The formation of DNA double-strand breaks (DSBs) is the most dangerous effect of ionizing radiation on the cellular level. After irradiation, cells activate a DNA damage response, the molecular path that determines the fate of the cell. As an important element of this, homologous recombination repair is a crucial pathway for the error-free repair of DNA lesions. All components of DNA damage response are regulated by specific microRNAs. MicroRNAs are single-stranded short noncoding RNAs of 20–25 nt in length. They are directly involved in the regulation of gene expression by repressing translation or by cleaving target mRNA. In the present review, we analyze the biological mechanisms by which miRNAs regulate cell response to ionizing radiation-induced double-stranded breaks with an emphasis on DNA repair by homologous recombination, and its main component, the RAD51 recombinase. On the other hand, we discuss the ability of DNA damage response proteins to launch particular miRNA expression and modulate the course of this process. A full understanding of cell response processes to radiation-induced DNA damage will allow us to develop new and more effective methods of ionizing radiation therapy for cancers, and may help to develop methods for preventing the harmful effects of ionizing radiation on healthy organisms.

scholarly journals Genome-wide multi-parametric analysis of H2AX or γH2AX distributions during ionizing radiation-induced DNA damage response

2013 ◽  
Vol 6 (S1) ◽  
Author(s):  
Francesco Natale ◽  
Alexander Rapp ◽  
Wei Yu ◽  
Marco Durante ◽  
Gisela Taucher-Scholz ◽  
...  
Keyword(s):  
Dna Damage ◽  
Ionizing Radiation ◽  
Dna Damage Response ◽  
Parametric Analysis ◽  
Genome Wide ◽  
Damage Response ◽  
Radiation Induced

scholarly journals NIMA-Related Protein Kinase 1 Is Involved Early in the Ionizing Radiation-Induced DNA Damage Response

2004 ◽  
Vol 64 (24) ◽  
pp. 8800-8803 ◽  
Author(s):  
Rosaria Polci ◽  
Aimin Peng ◽  
Phang-Lang Chen ◽  
Daniel J. Riley ◽  
Yumay Chen
Keyword(s):  
Dna Damage ◽  
Protein Kinase ◽  
Ionizing Radiation ◽  
Dna Damage Response ◽  
Related Protein ◽  
Damage Response ◽  
Radiation Induced
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