Single and double metallothionein knockout in the nematode C. elegans reveals cadmium dependent and independent toxic effects on life history traits

2007 ◽  
Vol 145 (2) ◽  
pp. 395-400 ◽  
Author(s):  
Sam Hughes ◽  
Stephen R. Stürzenbaum
Keyword(s):  
Life History ◽  
Life History Traits ◽  
Toxic Effects ◽  
C Elegans

scholarly journals Natural variation in fecundity is correlated with species-wide levels of divergence in Caenorhabditis elegans

2021 ◽  
Author(s):  
Gaotian Zhang ◽  
Jake D Mostad ◽  
Erik C Andersen
Keyword(s):  
Life History ◽  
Caenorhabditis Elegans ◽  
Life History Traits ◽  
Life History Trait ◽  
Selective Sweeps ◽  
C Elegans ◽  
Genome Wide ◽  
Genetic Complexity ◽  
Genomic Regions ◽  
Global Population

Abstract Life history traits underlie the fitness of organisms and are under strong natural selection. A new mutation that positively impacts a life history trait will likely increase in frequency and become fixed in a population (e.g. a selective sweep). The identification of the beneficial alleles that underlie selective sweeps provides insights into the mechanisms that occurred during the evolution of a species. In the global population of Caenorhabditis elegans, we previously identified selective sweeps that have drastically reduced chromosomal-scale genetic diversity in the species. Here, we measured the fecundity of 121 wild C. elegans strains, including many recently isolated divergent strains from the Hawaiian islands and found that strains with larger swept genomic regions have significantly higher fecundity than strains without evidence of the recent selective sweeps. We used genome-wide association (GWA) mapping to identify three quantitative trait loci (QTL) underlying the fecundity variation. Additionally, we mapped previous fecundity data from wild C. elegans strains and C. elegans recombinant inbred advanced intercross lines that were grown in various conditions and detected eight QTL using GWA and linkage mappings. These QTL show the genetic complexity of fecundity across this species. Moreover, the haplotype structure in each GWA QTL region revealed correlations with recent selective sweeps in the C. elegans population. North American and European strains had significantly higher fecundity than most strains from Hawaii, a hypothesized origin of the C. elegans species, suggesting that beneficial alleles that caused increased fecundity could underlie the selective sweeps during the worldwide expansion of C. elegans.

scholarly journals Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans Gene Expression and Life History Traits

Cell ◽  
2014 ◽  
Vol 156 (4) ◽  
pp. 759-770 ◽  
Author(s):  
Emma Watson ◽  
Lesley T. MacNeil ◽  
Ashlyn D. Ritter ◽  
L. Safak Yilmaz ◽  
Adam P. Rosebrock ◽  
...  
Keyword(s):  
Gene Expression ◽  
Life History ◽  
Systems Biology ◽  
Life History Traits ◽  
C Elegans

scholarly journals A sensitive mass spectrometry platform identifies metabolic changes of life history traits in C. elegans

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Arwen W. Gao ◽  
Iliana A. Chatzispyrou ◽  
Rashmi Kamble ◽  
Yasmine J. Liu ◽  
Katharina Herzog ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Life History ◽  
Life History Traits ◽  
Metabolic Changes ◽  
C Elegans

scholarly journals Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans Gene Expression and Life History Traits

Cell ◽  
2014 ◽  
Vol 156 (6) ◽  
pp. 1336-1337 ◽  
Author(s):  
Emma Watson ◽  
Lesley T. MacNeil ◽  
Ashlyn D. Ritter ◽  
L. Safak Yilmaz ◽  
Adam P. Rosebrock ◽  
...  
Keyword(s):  
Gene Expression ◽  
Life History ◽  
Systems Biology ◽  
Life History Traits ◽  
C Elegans

scholarly journals Natural variation in fertility is correlated with species-wide levels of divergence inCaenorhabditis elegans

2021 ◽  
Author(s):  
Gaotian Zhang ◽  
Jake D. Mostad ◽  
Erik C. Andersen
Keyword(s):  
Life History ◽  
Life History Traits ◽  
Life History Trait ◽  
Selective Sweeps ◽  
C Elegans ◽  
Genome Wide ◽  
Fertility Variation ◽  
The Face ◽  
Fertility Data ◽  
Genomic Regions

ABSTRACTLife history traits underlie the fitness of organisms and are under strong natural selection in the face of environmental challenges. A new mutation that positively impacts a life history trait will likely increase in frequency and become fixed in a population (e.g.selective sweep). The identification of the beneficial alleles that underlie selective sweeps provides insights into the mechanisms that occurred during the evolution of species. In the global population ofCaenorhabditis elegans,we previously identified selective sweeps that have drastically reduced chromosomal-scale genetic diversity in the species. Here, we measured the fertility (viable offspring) of a collection of wildC. elegansstrains, including many recently isolated divergent strains from the Hawaiian islands and found that strains with larger swept genomic regions on multiple chromosomes have significantly higher fertility than strains that do not have evidence of the recent selective sweeps. We used genome-wide association (GWA) mapping to identify three quantitative trait loci (QTL) underlying the fertility variation. Additionally, we mapped previous fertility data of wildC. elegansstrains andC. elegansrecombinant inbred advanced intercross lines (RIAILs) that were grown in various conditions and detected eight QTL across the genome using GWA and linkage mappings. These QTL show the genetic complexity of life history traits such as fertility across this species. Moreover, the haplotype structure in each GWA QTL region revealed correlations with recent selective sweeps in theC. eleganspopulation. North American and European strains had significantly higher fertility than most strains from Hawaii, a hypothesized origin of theC. elegansspecies, suggesting that beneficial alleles that cause increased fertility could underlie the selective sweeps during the worldwide expansion ofC. elegans.

Prey tell: what quillback rockfish early life history traits reveal about their survival in encounters with juvenile coho salmon

2020 ◽  
Vol 650 ◽  
pp. 7-18 ◽  
Author(s):  
HW Fennie ◽  
S Sponaugle ◽  
EA Daly ◽  
RD Brodeur
Keyword(s):  
Life History ◽  
Early Life ◽  
Life History Traits ◽  
Direct Evidence ◽  
Coho Salmon ◽  
Larval Fish ◽  
Early Life History ◽  
In The Wild ◽  
Otolith Microstructure Analysis ◽  
Pelagic Juvenile

Predation is a major source of mortality in the early life stages of fishes and a driving force in shaping fish populations. Theoretical, modeling, and laboratory studies have generated hypotheses that larval fish size, age, growth rate, and development rate affect their susceptibility to predation. Empirical data on predator selection in the wild are challenging to obtain, and most selective mortality studies must repeatedly sample populations of survivors to indirectly examine survivorship. While valuable on a population scale, these approaches can obscure selection by particular predators. In May 2018, along the coast of Washington, USA, we simultaneously collected juvenile quillback rockfish Sebastes maliger from both the environment and the stomachs of juvenile coho salmon Oncorhynchus kisutch. We used otolith microstructure analysis to examine whether juvenile coho salmon were age-, size-, and/or growth-selective predators of juvenile quillback rockfish. Our results indicate that juvenile rockfish consumed by salmon were significantly smaller, slower growing at capture, and younger than surviving (unconsumed) juvenile rockfish, providing direct evidence that juvenile coho salmon are selective predators on juvenile quillback rockfish. These differences in early life history traits between consumed and surviving rockfish are related to timing of parturition and the environmental conditions larval rockfish experienced, suggesting that maternal effects may substantially influence survival at this stage. Our results demonstrate that variability in timing of parturition and sea surface temperature leads to tradeoffs in early life history traits between growth in the larval stage and survival when encountering predators in the pelagic juvenile stage.

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