scholarly journals A review of environmental metabolism disrupting chemicals and effect biomarkers associating disease risks: Where exposomics meets metabolomics

2022 ◽  
Vol 158 ◽  
pp. 106941
Author(s):  
Jiachen Sun ◽  
Runcheng Fang ◽  
Hua Wang ◽  
De-Xiang Xu ◽  
Jing Yang ◽  
...  
Keyword(s):  
Disease Risks

Casual gaming as a means to raise awareness of vector-borne disease risks

2010 ◽  
Author(s):  
Tomás Francisco Yago Vincente ◽  
Brian Mullen ◽  
Thomas N. Mather ◽  
Jean-Yves Herve
Keyword(s):  
Vector Borne Disease ◽  
Disease Risks ◽  
Vector Borne

Association between Fitness and Coronary Heart Disease Risks among Healthy Adults

2012 ◽  
Vol 23 (3) ◽  
pp. 510-520
Author(s):  
박세정 ◽  
Byounggoo Ko ◽  
김양례 ◽  
정은지 ◽  
JungTaek Shin ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Healthy Adults ◽  
Disease Risks

scholarly journals Survey on Physicians’ Knowledge and Training Needs in Genetic Counseling in Germany

Breast Care ◽  
2020 ◽  
pp. 1-7
Author(s):  
Julia Dick ◽  
Viktoria Aue ◽  
Simone Wesselmann ◽  
Anne Brédart ◽  
Sylvie Dolbeault ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Counseling ◽  
High Throughput Sequencing ◽  
Training Needs ◽  
Breast Cancer Patients ◽  
Cross Sectional Survey ◽  
Counseling And Testing ◽  
Genetic Test Results ◽  
Disease Risks ◽  
And Training

<b><i>Background:</i></b> In recent years, germline testing of women with a risk of developing breast and ovarian cancer has increased rapidly. This is due to lower costs for new high-throughput sequencing technologies and the manifold preventive and therapeutic options for germline mutation carriers. The growing demand for genetic counseling meets a shortfall of counselors and illustrates the need to involve the treating clinicians in the genetic testing process. This survey was undertaken to assess their state of knowledge and training needs in the field of genetic counseling and testing. <b><i>Methods:</i></b> A cross-sectional survey within the European Bridges Study (Breast Cancer Risk after Diagnostic Gene Sequencing) was conducted among physician members (<i>n</i> = 111) of the German Cancer Society who were primarily gynecologists. It was designed to examine their experience in genetic counseling and testing. <b><i>Results:</i></b> Overall, the study revealed a need for training in risk communication and clinical recommendations for persons at risk. One-third of respondents communicated only relative disease risks (31.5%) instead of absolute disease risks in manageable time spans. Moreover, almost one-third of the respondents (31.2%) communicated bilateral and contralateral risk-reducing mastectomy as an option for healthy women and unilateral-diseased breast cancer patients without mutations in high-risk genes (e.g. <i>BRCA1</i> or <i>BRCA2)</i>. Most respondents expressed training needs in the field of risk assessment models, the clinical interpretation of genetic test results, and the decision-making process. <b><i>Conclusion:</i></b> The survey demonstrates a gap of genetic and risk literacy in a relevant proportion of physicians and the need for appropriate training concepts.

The role of genetics in fetal programming of adult cardiometabolic disease

2021 ◽  
pp. 1-8
Author(s):  
Carlos Sánchez-Soriano ◽  
Ewan R. Pearson ◽  
Rebecca M. Reynolds
Keyword(s):  
Cardiometabolic Disease ◽  
Genetic Determinants ◽  
Glucose And Lipid Metabolism ◽  
Developmental Growth ◽  
Genome Wide ◽  
Maternal Genotype ◽  
Disease Risks ◽  
Independent Effects ◽  
Meta Analyses

Abstract Disturbances affecting early development have broad repercussions on the individual’s health during infancy and adulthood. Multiple observational studies throughout the years have shown that alterations of fetal growth are associated with increased cardiometabolic disease risks. However, the genetic component of this association only started to be investigated in the last 40 years, when single genes with distinct effects were investigated. Birth weight (BW), commonly reported as the outcome of developmental growth, has been estimated to be 20% to 60% heritable. Through Genome-Wide Association (GWA) meta-analyses, 190 different loci have been identified being associated with BW, and while many of these loci designate genes involved in glucose and lipid metabolism, with clear ties to fetal development, the role of others is not yet understood. In addition, due to its influence over the intrauterine environment, the maternal genotype also plays an important part in the determination of offspring BW, with the same loci having independent effects of different magnitude or even direction. There is still much to uncover regarding the genetic determinants of BW and the interactions between maternal, offspring, and even paternal genotype. To fully understand these, diverse and novel cohorts from multiple ancestries collecting extensive neonatal phenotype will be needed. This review compiles, chronologically, the main findings in the investigation of the genetics of BW.

scholarly journals Ranking infectious disease risks to support preparedness prioritization in the European Union

2015 ◽  
Vol 25 (suppl_3) ◽  
Author(s):  
M Bouwknegt ◽  
A Havelaar ◽  
R Neslo ◽  
AM de Roda Husman ◽  
L Hogerwerf ◽  
...  
Keyword(s):  
Infectious Disease ◽  
European Union ◽  
The European Union ◽  
Disease Risks
Sign in / Sign up

Export Citation Format

Share Document