Short-term exposure to high ambient air pollution increases airway inflammation and respiratory symptoms in chronic obstructive pulmonary disease patients in Beijing, China

2016 ◽  
Vol 94 ◽  
pp. 76-82 ◽  
Author(s):  
Shaowei Wu ◽  
Yang Ni ◽  
Hongyu Li ◽  
Lu Pan ◽  
Di Yang ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Air Pollution ◽  
Respiratory Symptoms ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Chronic Obstructive ◽  
Short Term ◽  
Obstructive Pulmonary Disease ◽  
Short Term Exposure ◽  
Beijing China

scholarly journals Association Between Ambient Air Pollution and Mortality From Chronic Obstructive Pulmonary Disease in Wuhan, China: a Population-based Time-series Study

2020 ◽  
Author(s):  
Yaqiong Yan ◽  
Lu She ◽  
Yan Guo ◽  
Yuanyuan Zhao ◽  
Pei Zhang ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Air Pollution ◽  
Time Series ◽  
Subgroup Analysis ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Chronic Obstructive ◽  
Short Term ◽  
Obstructive Pulmonary Disease ◽  
Copd Mortality

Abstract Background: Previous studies have mainly focused on the associations between air pollution and total respiratory disease mortality. However, evidence on the short-term effects of air pollution on chronic obstructive pulmonary disease (COPD) mortality is still not conclusive to date. The aim of this study was to investigate the short-term effects of ambient air pollution on COPD mortality in Wuhan China.Methods: Daily death numbers, concentrations of air pollutants (PM2.5, PM10, SO2, NO2, and O3) and meteorological characteristics in Wuhan between January 1, 2014 to December 31, 2019 were collected. Time-series analysis using generalized additive model was applied to evaluated the association between ambient air pollution and daily COPD mortality. Subgroup analysis by age (<65 and ≥65 year) and sex (male and female) were also conducted. Results: During the study period, we observed a total of 16150 deaths(7.37 deaths per day) from COPD. The daily average concentrations of PM2.5, PM10, SO2, NO2 and O3 were 59.03, 90.48, 12.91, 48.84 and 91.77 µg/m3, respectively. In single pollutant model, for every increase of 10 µg/m3 in PM10, SO2, NO2 levels, COPD mortality increased by 0.581%(95CI:0.054%-1.111%), 4.316%(95CI:1.002%-7.738%) and 1.815%(95CI:0.523%-3.125%) at lag03, respectively. No significant associations were found for PM2.5 and O3. Subgroup analysis demonstrated that females were more susceptible to PM2.5, PM10, SO2 and NO2, in addition the concentrations of PM10, SO2 and NO2 were significantly associated with COPD mortality for older adults. In two-pollutant models, the significantly positive associations between SO2 as well as NO2 and COPD mortality remained after adjusting for PM2.5 or O3.Conclusions: Short-term exposure to PM10, SO2, and NO2 are significantly associated with a higher risk of COPD mortality. Female or elderly are more susceptible to air pollution. Further research is required to reveal the underlying mechanisms. The implementation of the environmental protection policy has become urgent.

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