Organic compounds in tire particle induce reactive oxygen species and heat-shock proteins in the human alveolar cell line A549

2008 ◽  
Vol 34 (4) ◽  
pp. 437-442 ◽  
Author(s):  
Maurizio Gualtieri ◽  
Paride Mantecca ◽  
Francesco Cetta ◽  
Marina Camatini
Keyword(s):  
Reactive Oxygen Species ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Cell Line ◽  
Organic Compounds ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Alveolar Cell ◽  
Shock Proteins

Hyperoxia-induced preconditioning against renal ischemic injury is mediated by reactive oxygen species but not related to heat shock proteins 70 and 32

Surgery ◽  
2015 ◽  
Vol 157 (6) ◽  
pp. 1014-1022 ◽  
Author(s):  
Hannaneh Wahhabaghai ◽  
Reza Heidari ◽  
Atefeh Zeinoddini ◽  
Saeed Soleyman-Jahi ◽  
Leila Golmanesh ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Reactive Oxygen ◽  
Ischemic Injury ◽  
Oxygen Species ◽  
Shock Proteins

scholarly journals Small Heat-Shock Proteins, IbpAB, Protect Non-Pathogenic Escherichia coli from Killing by Macrophage-Derived Reactive Oxygen Species

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0120249 ◽  
Author(s):  
Laura Goeser ◽  
Ting-Jia Fan ◽  
Sandrine Tchaptchet ◽  
Nikolas Stasulli ◽  
William E. Goldman ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Reactive Oxygen Species ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Reactive Oxygen ◽  
Small Heat Shock Proteins ◽  
Oxygen Species ◽  
Pathogenic Escherichia Coli ◽  
Shock Proteins

scholarly journals The Influence of Hyperoxia On Heat Shock Proteins Expression and Nitric Oxide Synthase Activity – the Review

2017 ◽  
Vol 58 (1) ◽  
pp. 23-28
Author(s):  
Jakub Szyller ◽  
Mariusz Kozakiewicz ◽  
Piotr Siermontowski
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Nitrogen Oxide ◽  
Nitrosative Stress ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Shock Proteins ◽  
Oxide Synthase

Abstract Any stay in an environment with an increased oxygen content (a higher oxygen partial pressure, pO2) and an increased pressure (hyperbaric conditions) leads to an intensification of oxidative stress. Reactive oxygen species (ROS) damage the molecules of proteins, nucleic acids, cause lipid oxidation and are engaged in the development of numerous diseases, including diseases of the circulatory system, neurodegenerative diseases, etc. There are certain mechanisms of protection against unfavourable effects of oxidative stress. Enzymatic and non-enzymatic systems belong to them. The latter include, among others, heat shock proteins (HSP). Their precise role and mechanism of action have been a subject of intensive research conducted in recent years. Hyperoxia and hyperbaria also have an effect on the expression and activity of nitrogen oxide synthase (NOS). Its product - nitrogen oxide (NO) can react with reactive oxygen species and contribute to the development of nitrosative stress. NOS occurs as isoforms in various tissues and exhibit different reactions to the discussed factors. The authors have prepared a brief review of research determining the effect of hyperoxia and hyperbaria on HSP expression and NOS activity.

Cardioprotective effects of iroxanadine: Role of nitric oxide, reactive oxygen species and heat-shock proteins

2002 ◽  
Vol 34 (6) ◽  
pp. A3
Author(s):  
Károly Acsai ◽  
Csaba Csonka ◽  
Andrea Jednákovits ◽  
Krisztián Stadler ◽  
Zoltán Pénzes ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Cardioprotective Effects ◽  
Shock Proteins

Reactive Oxygen Species-Mediated Apoptosis and Cytotoxicity of Newly Synthesized Pyridazin-3-Ones In P815 (Murin Mastocytoma) Cell Line

Drug Research ◽  
2019 ◽  
Vol 69 (10) ◽  
pp. 528-536
Author(s):  
Najat Bouchmaa ◽  
Reda Ben Mrid ◽  
Youness Boukharsa ◽  
Youssef Bouargalne ◽  
Mohamed Nhiri ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Anticancer Activity ◽  
Cell Line ◽  
Cytotoxic Effect ◽  
Redox Homeostasis ◽  
Reactive Oxygen ◽  
Cytotoxic Activities ◽  
Oxygen Species ◽  
P815 Cell

Abstract Background In cancer cells, the intracellular antioxidant capacity and the redox homeostasis are mainly maintained by the glutathione- and thioredoxin-dependent systems which are considered as promising targets for anticancer drugs. Pyridazinones constitute an interesting source of heterocyclic compounds for drug discovery. The present investigation focused on studying the in-vitro antitumor activity of newly synthesized Pyridazin-3(2h)-ones derivatives against P815 (Murin mastocytoma) cell line. Methods The in-vitro cytotoxic activities were investigated toward the P815 cell line using tetrazolium-based MTT assay. Lipid peroxidation and the specific activities of antioxidant enzymes were also determined. Results The newly compounds had a selective dose-dependent cytotoxic effect without affecting normal cells (PBMCs). Apoptosis was further confirmed through the characteristic apoptotic morphological changes and DNA fragmentation. Two compounds (6f and 7h) were highly cytotoxic and were submitted to extend biological testing to determine the likely mechanisms of their cytotoxicity. Results showed that these molecules may induce cytotoxicity via disturbing the redox homeostasis. Importantly, the anticancer activity of 6f and 7h could be due to the intracellular reactive oxygen species hypergeneration through significant loss of glutathione reductase and thioredoxin reductase activities. This eventually leads to oxidative stress-mediated P815 cell apoptosis. Furthermore, the co-administration of 6f or 7h with Methotrexate exhibited a synergistic cytotoxic effect. Conclusions considering their significant anticancer activity and chemosensitivity, 6f and 7h may improve the therapeutic efficacy of the current treatment for cancer.

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