Influence of parallel nozzle electroencapsulation parameters on microcapsule properties – A case study using the Taguchi robust design method

2017 ◽  
Vol 90 ◽  
pp. 91-105 ◽  
Author(s):  
Jorma Roine ◽  
Matti Murtomaa ◽  
Jarno Salonen
Keyword(s):  
Robust Design ◽  
Design Method ◽  
Robust Design Method ◽  
Taguchi Robust Design

scholarly journals Development of ethosomes with taguchi robust design-based studies for transdermal delivery of alfuzosin hydrochloride

2012 ◽  
Vol 1 (11) ◽  
pp. 370-375 ◽  
Author(s):  
D Prasanthi ◽  
P K Lakshmi
Keyword(s):  
Robust Design ◽  
Transdermal Delivery ◽  
Design Method ◽  
Entrapment Efficiency ◽  
Pharmaceutical Journal ◽  
Dependent Variables ◽  
Alfuzosin Hydrochloride ◽  
Robust Design Method ◽  
Taguchi Robust Design ◽  
Drug Solution

In the present investigation efficiency of ethosomes as novel lipid carriers for transdermal delivery of Alfuzosin Hydrochloride (AH) has been evaluated. Taguchi robust design method was used for optimization of ethosomal formulations. Phospholipid type, concentration of phospholipid and concentration of ethanol was selected as independent variables and their effect on the dependent variables (entrapment efficiency and flux) was studied. Ethosomal formulation (EA8) with soya phosphatidylcholine (3%) and ethanol 20% were optimized. Vesicles were spherical, unilamellar with smooth surface. The optimized formulation exhibited vesicle size (6.85 ± 1.35µm), zeta potential (-8.14 ± 0.62mv), entrapment efficiency (91.86 ± 3.25%), flux (27.42 ± 0.04µg/cm2/hr), lag time (0.26±0.20hr) and skin deposition (298.01 ± 15.4µg/g). Transdermal flux was enhanced by 6.92 times over drug solution. Vesicle skin interaction studies showed fatty change in the dermis. The formulations were stable at 4°C for 120 days. Results suggested ethosomes as efficient carriers for AH transdermal delivery.DOI: http://dx.doi.org/10.3329/icpj.v1i11.12063 International Current Pharmaceutical Journal 2012, 1(11): 370-375

scholarly journals Investigation and Optimization of Sn/Gr Lubricants Effects on Cold Extrudability of Fe-TiC Nanocomposite Using Taguchi Robust Design Method

Engineering ◽  
2011 ◽  
Vol 03 (07) ◽  
pp. 700-707 ◽  
Author(s):  
Seyed Abdolkarim Sajjadi ◽  
Seyed Mojtaba Zebarjad ◽  
Nasrin Sasani ◽  
Heydar Khadivi ◽  
Behrooz Naderi
Keyword(s):  
Robust Design ◽  
Design Method ◽  
Robust Design Method ◽  
Taguchi Robust Design

OPTIMIZATION OF PARAMETERS FOR THE SYNTHESIS OF SILVER IODATE SUBMICRON BELTS BY TAGUCHI ROBUST DESIGN METHOD

2011 ◽  
Vol 198 (10) ◽  
pp. 1182-1188 ◽  
Author(s):  
S. M. Pourmortazavi ◽  
S. S. Hajimirsadeghi ◽  
M. Rahimi-Nasrabadi ◽  
I. Kohsari
Keyword(s):  
Robust Design ◽  
Design Method ◽  
Optimization Of Parameters ◽  
Robust Design Method ◽  
Taguchi Robust Design

Optimal Robust Design of Multiple Response Problems of Compliant Mechanism Based on the Response Surface Methodology

2014 ◽  
Vol 643 ◽  
pp. 310-315 ◽  
Author(s):  
Jian Jun Wu ◽  
Shi Lang Wu ◽  
Xiong Xiong You
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Robust Design ◽  
Optimization Design ◽  
Compliant Mechanism ◽  
Design Method ◽  
Multiple Response ◽  
Potential Applications ◽  
Robust Design Method

Optimal robust design for multiple response problems is becoming more important for compliant mechanism. However, there are now still need effective methods for complex multiple response problems in the design process of compliant mechanism. In this paper, through the Response Surface Methodology (RSM), a novel optimal robust design method for the flexibility relationships of the 3-RRR compliant parallel micromotion platform along the X、Y direction and the rotation around the Z axis is proposed. Analysed the influence of different size parameters of flexible hinge to the compliant parallel micromotion platform different direction flexibility, the optimized complex multiple response variables of the compliant parallel micromotion platform and the best robust solutions are developed. And a real case study is used to demonstrate the implementation and potential applications of the proposed method for optimization design of compliant mechanism with considering complex multiple response problems.

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