Covalent modification of carbon nanotubes with anthraquinone by electrochemical grafting and solid phase synthesis

2012 ◽  
Vol 68 ◽  
pp. 74-80 ◽  
Author(s):  
Mohamed A. Ghanem ◽  
Izzet Kocak ◽  
Abdullah Al-Mayouf ◽  
Mansour AlHoshan ◽  
Philip N. Bartlett
Keyword(s):  
Carbon Nanotubes ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Covalent Modification ◽  
Phase Synthesis

Covalent modification of glassy carbon surface with organic redox probes through diamine linkers using electrochemical and solid-phase synthesis methodologies

2008 ◽  
Vol 18 (41) ◽  
pp. 4917 ◽  
Author(s):  
Mohamed A. Ghanem ◽  
Jean-Mathieu Chrétien ◽  
Aleksandra Pinczewska ◽  
Jeremy D. Kilburn ◽  
Philip N. Bartlett
Keyword(s):  
Glassy Carbon ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Covalent Modification ◽  
Carbon Surface ◽  
Phase Synthesis ◽  
Glassy Carbon Surface

Synthesis and Screening of A DNA-Encoded Library of Non-Peptidic Macrocycles

2020 ◽  
Author(s):  
Eric Koesema ◽  
Animesh Roy ◽  
Nicholas G. Paciaroni ◽  
Thomas Kodadek
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cell Permeability ◽  
Phase Synthesis ◽  
Protein Ligands ◽  
High Affinity ◽  
Scaffold Diversity

There is considerable interest in the development of libraries of non-peptidic macrocycles as a source of ligands for difficult targets. We report here the solid-phase synthesis of a DNA-encoded library of several hundred thousand thioether-linked macrocycles. The library was designed to be highly diverse with respect to backbone scaffold diversity and to minimize the number of amide N-H bonds, which compromise cell permeability. The utility of the library as a source of protein ligands is demonstrated through the isolation of compounds that bind streptavidin, a model target, with high affinity.

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