Electrochemical biosensors for the monitoring of DNA damage induced by ferric ions mediated oxidation of dopamine

2013 ◽  
Vol 28 ◽  
pp. 91-94 ◽  
Author(s):  
Miaomiao Chen ◽  
Huayu Xiong ◽  
Xiuhua Zhang ◽  
Haoshuang Gu ◽  
Shengfu Wang
Keyword(s):  
Dna Damage ◽  
Electrochemical Biosensors ◽  
Ferric Ions ◽  
Mediated Oxidation

Enhanced DNA binding capacity on up‐regulated epidermal wild‐type p53 in vitiligo by H 2 O 2 ‐mediated oxidation: a possible repair mechanism for DNA damage

2009 ◽  
Vol 23 (11) ◽  
pp. 3790-3807 ◽  
Author(s):  
Mohamed M. A. E. L. Salem ◽  
Mohammad Shalbaf ◽  
Nicholas C. J. Gibbons ◽  
Bhaven Chavan ◽  
J. M. Thornton ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Binding ◽  
Binding Capacity ◽  
Wild Type ◽  
Repair Mechanism ◽  
Wild Type P53 ◽  
Mediated Oxidation

Chapter 20 DNA-electrochemical biosensors for investigating DNA damage

2007 ◽  
pp. 413-437 ◽  
Author(s):  
Ana M. Oliveira Brett ◽  
Victor C. Diculescu ◽  
Ana M. Chiorcea-Paquim ◽  
Silvia H.P. Serrano
Keyword(s):  
Dna Damage ◽  
Electrochemical Biosensors

scholarly journals DNA Electrochemical Biosensors for In Situ Probing of Pharmaceutical Drug Oxidative DNA Damage

Sensors ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 1125 ◽  
Author(s):  
Ana-Maria Chiorcea-Paquim ◽  
Ana Maria Oliveira-Brett
Keyword(s):  
Dna Damage ◽  
Electrode Surface ◽  
Oxidative Dna Damage ◽  
Electrochemical Biosensor ◽  
Electrochemical Biosensors ◽  
Label Free ◽  
Dna Electrochemical Biosensor ◽  
Wide Range ◽  
Label Free Detection

Deoxyribonucleic acid (DNA) electrochemical biosensors are devices that incorporate immobilized DNA as a molecular recognition element on the electrode surface, and enable probing in situ the oxidative DNA damage. A wide range of DNA electrochemical biosensor analytical and biotechnological applications in pharmacology are foreseen, due to their ability to determine in situ and in real-time the DNA interaction mechanisms with pharmaceutical drugs, as well as with their degradation products, redox reaction products, and metabolites, and due to their capacity to achieve quantitative electroanalytical evaluation of the drugs, with high sensitivity, short time of analysis, and low cost. This review presents the design and applications of label-free DNA electrochemical biosensors that use DNA direct electrochemical oxidation to detect oxidative DNA damage. The DNA electrochemical biosensor development, from the viewpoint of electrochemical and atomic force microscopy (AFM) characterization, and the bottom-up immobilization of DNA nanostructures at the electrode surface, are described. Applications of DNA electrochemical biosensors that enable the label-free detection of DNA interactions with pharmaceutical compounds, such as acridine derivatives, alkaloids, alkylating agents, alkylphosphocholines, antibiotics, antimetabolites, kinase inhibitors, immunomodulatory agents, metal complexes, nucleoside analogs, and phenolic compounds, which can be used in drug analysis and drug discovery, and may lead to future screening systems, are reviewed.

Electrochemical biosensors for DNA hybridization and DNA damage

1998 ◽  
Vol 13 (6) ◽  
pp. 621-628 ◽  
Author(s):  
Emil Paleček ◽  
Miroslav Fojta ◽  
Miroslav Tomschik ◽  
Joseph Wang
Keyword(s):  
Dna Damage ◽  
Dna Hybridization ◽  
Electrochemical Biosensors

1576: Prediction of Spermatozoal DNA Damage by a Novel Semen Quality Score

2004 ◽  
Vol 171 (4S) ◽  
pp. 416-416
Author(s):  
Tamer M. Said ◽  
Shyam Allamaneni ◽  
Kiran P. Nallella ◽  
Rakesh K. Sharma ◽  
Sijo J. Parekattil ◽  
...  
Keyword(s):  
Dna Damage ◽  
Semen Quality ◽  
Quality Score
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