scholarly journals Editor's Choice – Endovascular vs. Open Repair for Abdominal Aortic Aneurysm: Systematic Review and Meta-analysis of Updated Peri-operative and Long Term Data of Randomised Controlled Trials

2020 ◽  
Vol 59 (3) ◽  
pp. 385-397 ◽  
Author(s):  
George A. Antoniou ◽  
Stavros A. Antoniou ◽  
Francesco Torella
Keyword(s):  
Systematic Review ◽  
Abdominal Aortic Aneurysm ◽  
Randomised Controlled Trials ◽  
Open Repair ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Abdominal Aortic ◽  
Randomised Controlled ◽  
Term Data

Effect of blood pressure lowering drugs and antibiotics on abdominal aortic aneurysm growth: a systematic review and meta-analysis

Heart ◽  
2020 ◽  
pp. heartjnl-2020-318192
Author(s):  
Jonathan Golledge ◽  
Tejas P Singh
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Abdominal Aortic Aneurysm ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Blood Pressure Lowering ◽  
Abdominal Aortic ◽  
Pressure Lowering ◽  
Randomised Controlled

ObjectiveThere is currently no medical treatment proven to limit abdominal aortic aneurysm (AAA) progression. The aim of this systematic review and meta-analysis was to pool data from previous randomised controlled trials assessing the efficacy of blood pressure-lowering and antibiotic medications in limiting AAA growth and AAA-related events, that is, rupture or repair.MethodsA systematic literature search was performed to identify randomised controlled trials that examined the efficacy of blood pressure-lowering medications or antibiotics in reducing AAA growth and AAA-related events. AAA growth (mm/year) was measured by ultrasound or computed tomography imaging. Meta-analyses were performed using random effects models. A subanalysis was conducted including trials that investigated tetracycline or macrolide antibiotics.ResultsTen randomised controlled trials including 2045 participants with an asymptomatic AAA were included. Follow-up was between 18 and 63 months. Neither blood pressure-lowering medications (mean growth±SD 2.0±2.4 vs 2.3±2.7 mm/year; standardised mean difference (SMD) −0.07, 95% CI −0.19 to 0.06; p=0.288) or antibiotics (mean growth±SD 2.6±2.1 vs 2.6±2.5 mm/year; SMD −0.11, 95% CI −0.38 to 0.16; p=0.418) reduced AAA growth or AAA-related events (blood pressure-lowering medications: 92 vs 95 events; risk ratio (RR) 0.86, 95% CI 0.66 to 1.11; p=0.244; and antibiotics: 69 vs 73 events; RR 0.93, 95% CI 0.69 to 1.25; p=0.614). The subanalysis of antibiotics showed similar results.ConclusionsThis meta-analysis suggests that neither blood pressure-lowering medications or antibiotics limit growth or clinically relevant events in people with AAAs.

scholarly journals A systematic review and meta-analysis of the long-term outcomes of endovascular versus open repair of abdominal aortic aneurysm

2019 ◽  
Vol 70 (3) ◽  
pp. 954-969.e30 ◽  
Author(s):  
Ben Li ◽  
Shawn Khan ◽  
Konrad Salata ◽  
Mohamad A. Hussain ◽  
Charles de Mestral ◽  
...  
Keyword(s):  
Systematic Review ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Open Repair ◽  
Meta Analysis ◽  
Long Term Outcomes ◽  
Abdominal Aortic
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