scholarly journals Therapeutic Outcomes of Transplanting Human Umbilical Cord Mesenchymal Stem Cells in Patients with Critical Limb Ischemia

2019 ◽  
Vol 58 (6) ◽  
pp. e388-e389
Author(s):  
Pingping Huang
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Critical Limb Ischemia ◽  
Limb Ischemia ◽  
Human Umbilical Cord ◽  
Therapeutic Outcomes

scholarly journals Human umbilical cord-derived mesenchymal stem cells treatment for refractory uveitis: a case series

2021 ◽  
Vol 14 (11) ◽  
pp. 1784-1790
Author(s):  
Jing Yang ◽  
◽  
Xi-Teng Chen ◽  
Yuan-Feng Jiang ◽  
Zhi-Bo Han ◽  
...  
Keyword(s):  
Stem Cells ◽  
Visual Acuity ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Immunosuppressive Agents ◽  
Case Series ◽  
Oral Steroid ◽  
Human Umbilical Cord ◽  
Therapeutic Outcomes ◽  
Snellen Chart

AIM: To evaluate therapeutic outcomes of human umbilical cord-derived mesenchymal stem cells (HUC-MSCs) treatment in patients with refractory uveitis. METHODS: A retrospective and noncomparative review was performed on four patients with refractory uveitis from December 2013 to December 2017. HUC-MSCs were administered intravenously at a dose of 1×106 cells/kg. Clinical response, relapse rate, change of visual acuity, and other metrics were evaluated. RESULTS: All four patients presented with responses to HUC-MSCs treatment, with three males and one female. The numbers of uveitis attacks per year after the HUC-MSCs treatment (0, 2, 0, 0 respectively) all decreased compared with the numbers before the treatment (3, 6, 4, 4 respectively). The oral steroid and immunosuppressive agents were tapered in all patients without recrudescence of ocular inflammation, and three patients discontinued their oral medicine at the last visit. The best corrected visual acuity (BCVA) of 3 patients was improved to varying degrees, and the BCVA of 1 patient remained at 20/20 (Snellen chart) from the first to the last consultation. CONCLUSION: The study provides an effective therapy of HUC-MSCs in maintaining remission in patients affected by uveitis refractory to previous immunosuppressant treatments.

Human Umbilical Cord-Derived Mesenchymal Stem Cells Relieve Hind Limb Ischemia by Promoting Angiogenesis in Mice

2019 ◽  
Vol 28 (20) ◽  
pp. 1384-1397 ◽  
Author(s):  
Zhecun Wang ◽  
Liang Zheng ◽  
Chong Lian ◽  
Yunling Qi ◽  
Wen Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Hind Limb ◽  
Limb Ischemia ◽  
Human Umbilical Cord ◽  
Hind Limb Ischemia

Effectiveness of umbilical cord mesenchymal stem cells in patients with critical limb ischemia

2019 ◽  
Vol 153 (9) ◽  
pp. 341-346
Author(s):  
Wen-Hui Gao ◽  
Hong-Ye Gao ◽  
Yue-Tong Li ◽  
Ping-Ping Huang
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Critical Limb Ischemia ◽  
Limb Ischemia
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