scholarly journals Peripheral Arterial Disease Incidence and Associated Risk Factors in a Mediterranean Population-based Cohort. The REGICOR Study

2016 ◽  
Vol 51 (5) ◽  
pp. 696-705 ◽  
Author(s):  
A. Velescu ◽  
A. Clara ◽  
J. Peñafiel ◽  
M. Grau ◽  
I.R. Degano ◽  
...  
Keyword(s):  
Risk Factors ◽  
Peripheral Arterial Disease ◽  
Disease Incidence ◽  
Arterial Disease ◽  
Population Based ◽  
Mediterranean Population ◽  
Associated Risk Factors ◽  
Peripheral Arterial

Abstract P248: Oxidized Phospholipids and Risk of Peripheral Arterial Disease in Men

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Monica L Bertoia ◽  
Jennifer K Pai ◽  
Sotirios Tsimikas ◽  
Michel M Joosten ◽  
Murray A Mittleman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Peripheral Arterial Disease ◽  
Conditional Logistic Regression ◽  
Ankle Brachial Index ◽  
Arterial Disease ◽  
Population Based ◽  
Oxidized Phospholipids ◽  
Blood Draw ◽  
Peripheral Arterial ◽  
Conventional Risk Factors

Background: Peripheral arterial disease (PAD) is highly prevalent, found in 25% of adults ≥70 years, but its risk factors are less well studied than coronary and carotid atherosclerosis. Proinflammatory oxidized phospholipids (OxPL) are a novel cardiovascular risk factor produced by oxidative stress and are preferentially bound and transported by lipoprotein (a) [Lp(a)] in plasma. Previous studies have shown an association between OxPL on apolipoprotein B-100 (OxPL/apoB) and carotid and femoral atherosclerosis. However, no previous studies have specifically examined the prospective association between OxPL/apoB and risk of PAD in a population-based cohort. Methods: We conducted a nested case-control study among men free of cardiovascular disease within the Health Professionals Follow-up Study (1994–2008) including 143 men with PAD and 429 controls matched on age, month of blood draw, and smoking. OxPL/apoB and Lp(a) were measured in stored baseline plasma. We identified cases of clinically significant PAD based on at least one of the following: (1) amputation, bypass, or other revascularization procedure for occlusive arterial disease, (2) angiogram/ultrasound confirming at least 50% stenosis of at least one artery with congruent symptoms in the ipsilateral limb, (3) ankle-brachial index < 0.9, or (4) physician's diagnosis. We used conditional logistic regression to estimate odds ratios (OR) for PAD according to level of OxPL/apoB. Results: The OR for PAD was 1.24 (95% CI 1.05–1.46) for each 1-standard deviation (SD) increase in OxPL/apoB after adjusting for matching factors. Additional adjustment for family history of MI, triglycerides, HDL-C, LDL-C, C-reactive protein, hemoglobin A1c, pack-years of smoking, physical activity, hypertension, diabetes, hypercholesterolemia, body-mass index, and aspirin use did not change this estimate: 1.24 (95% CI 1.00–1.54). OxPL/apoB was not correlated with any conventional risk factors: Spearman correlation coefficients ranged from 0.0 to 0.13. We observed no interaction with age or LDL-C. Similarly, the OR for PAD was 1.25 (95% CI 0.95–1.63) for each 1- SD increase in ln[Lp(a)] after adjusting for all of the above covariates. Conclusion: OxPL/apoB is positively associated with risk of PAD in men with no appreciable attenuation after adjustment for conventional risk factors.

scholarly journals Prevalence and Correlates of Peripheral Arterial Disease in Nigerians with Type 2 Diabetes

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
D. O. Soyoye ◽  
R. T. Ikem ◽  
B. A. Kolawole ◽  
K. S. Oluwadiya ◽  
R. A. Bolarinwa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Male Gender ◽  
Healthy Controls ◽  
Associated Risk Factors ◽  
Peripheral Arterial ◽  
Apparently Healthy

Background. Peripheral arterial disease (PAD) is a major risk factor for nonhealing foot ulcers in people with diabetes. A number of traditional risk factors have been reported to be associated with PAD; however, there may be a need to consider nontraditional risk factors especially in some vulnerable populations. This study determined the prevalence and risk factors associated with PAD in diabetics.Methods. One hundred and fifty type 2 diabetics and an equal number of age- and sex-matched apparently healthy controls were studied. Assessment of PAD was made using history, palpation of lower limb vessels, and measurement of ankle-brachial index (ABI). Statistically significant differences between categorical and continuous variables were determined using Chi square (χ2) and Studentt-tests, respectively. Regression analysis was done to determine the associated risk factors for PAD.Results. Prevalence of PAD using ABI was 22.0% and 8.0% among diabetic and nondiabetic populations, respectively. Peripheral arterial disease was associated with age, male gender, waist circumference, and high-sensitivity C-reactive protein.Conclusion. This study highlights the high prevalence of PAD in people with type 2 diabetes mellitus and in apparently healthy controls; age, male gender, abdominal obesity, and high hs-CRP values were the associated risk factors.

Risk factors for peripheral arterial disease incidence in persons with diabetes: the Atherosclerosis Risk in Communities (ARIC) Study

2005 ◽  
Vol 180 (2) ◽  
pp. 389-397 ◽  
Author(s):  
Keattiyoat Wattanakit ◽  
Aaron R. Folsom ◽  
Elizabeth Selvin ◽  
Beth D. Weatherley ◽  
James S. Pankow ◽  
...  
Keyword(s):  
Risk Factors ◽  
Peripheral Arterial Disease ◽  
Disease Incidence ◽  
Arterial Disease ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Peripheral Arterial ◽  
Aric Study

scholarly journals Cardiovascular Risk Factors Associated With Peripheral Arterial Disease in a Mediterranean Population

2019 ◽  
Vol 58 (6) ◽  
pp. e827-e828
Author(s):  
Gabriela Goncalves Martins ◽  
Daniel Gil Sala ◽  
Cristina Tello Diaz ◽  
Xavier Tenezaca Sari ◽  
Carlos Marrero Eligio de la puente ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Peripheral Arterial Disease ◽  
Cardiovascular Risk Factors ◽  
Arterial Disease ◽  
Mediterranean Population ◽  
Factors Associated ◽  
Peripheral Arterial
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