scholarly journals Local Diameter, Wall Stress and Thrombus Thickness Influence the Local Growth of Abdominal Aortic Aneurysms

2014 ◽  
Vol 48 (3) ◽  
pp. 349 ◽  
Author(s):  
G. Martufi ◽  
M. Lindquist Liljeqvist ◽  
N. Sakalihasan ◽  
G. Panuccio ◽  
R. Hultgren ◽  
...  
Keyword(s):  
Wall Stress ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Local Growth ◽  
Abdominal Aortic ◽  
Local Diameter

Local Diameter, Wall Stress, and Thrombus Thickness Influence the Local Growth of Abdominal Aortic Aneurysms

2016 ◽  
Vol 23 (6) ◽  
pp. 957-966 ◽  
Author(s):  
Giampaolo Martufi ◽  
Moritz Lindquist Liljeqvist ◽  
Natzi Sakalihasan ◽  
Giuseppe Panuccio ◽  
Rebecka Hultgren ◽  
...  
Keyword(s):  
Growth Rate ◽  
Cross Sections ◽  
High Stress ◽  
Wall Stress ◽  
Abdominal Aortic Aneurysms ◽  
Stress Sensitivity ◽  
Aortic Aneurysms ◽  
Local Growth ◽  
Abdominal Aortic ◽  
Local Diameter

Purpose: To investigate the influence of the local diameter, the intraluminal thrombus (ILT) thickness, and wall stress on the local growth rate of abdominal aortic aneurysms. Methods: The infrarenal aortas of 90 asymptomatic abdominal aortic aneurysm (AAA) patients (mean age 70 years; 77 men) were retrospectively reconstructed from at least 2 computed tomography angiography scans (median follow-up of 1 year) and biomechanically analyzed with the finite element method. Each individual AAA model was automatically sliced orthogonally to the lumen centerline and represented by 100 cross sections with corresponding diameters, ILT thicknesses, and wall stresses. The data were grouped according to these parameters for comparison of differences among the variables. Results: Diameter growth was continuously distributed over the entire aneurysm sac, reaching absolute and relative median peaks of 3.06 mm/y and 7.3%/y, respectively. The local growth rate was dependent on the local baseline diameter, the local ILT thickness, and for wall segments not covered by ILT, also on the local wall stress level (all p<0.001). For wall segments that were covered by a thick ILT layer, wall stress did not affect the growth rate (p=0.08). Conclusion: Diameter is not only a strong global predictor but also a local predictor of aneurysm growth. In addition, and independent of the diameter, the ILT thickness and wall stress (for the ILT-free wall) also influence the local growth rate. The high stress sensitivity of nondilated aortic walls suggests that wall stress peaks could initiate AAA formation. In contrast, local diameters and ILT thicknesses determine AAA growth for dilated and ILT-covered aortic walls.

scholarly journals Mechanical and geometrical determinants of wall stress in abdominal aortic aneurysms: A computational study

PLoS ONE ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. e0192032 ◽  
Author(s):  
Dara Azar ◽  
Donya Ohadi ◽  
Alexander Rachev ◽  
John F. Eberth ◽  
Mark J. Uline ◽  
...  
Keyword(s):  
Computational Study ◽  
Wall Stress ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Abdominal Aortic

Pulsatile Flow in Fusiform Models of Abdominal Aortic Aneurysms: Flow Fields, Velocity Patterns and Flow-Induced Wall Stresses

2004 ◽  
Vol 126 (4) ◽  
pp. 438-446 ◽  
Author(s):  
Robert A. Peattie ◽  
Tiffany J. Riehle ◽  
Edward I. Bluth
Keyword(s):  
Shear Stress ◽  
Pulsatile Flow ◽  
Maximum Shear Stress ◽  
Wall Stress ◽  
Abdominal Aortic Aneurysms ◽  
Flow Fields ◽  
Aortic Aneurysms ◽  
Abdominal Aortic ◽  
Risk Of Rupture

As one important step in the investigation of the mechanical factors that lead to rupture of abdominal aortic aneurysms, flow fields and flow-induced wall stress distributions have been investigated in model aneurysms under pulsatile flow conditions simulating the in vivo aorta at rest. Vortex pattern emergence and evolution were evaluated, and conditions for flow stability were delineated. Systolic flow was found to be forward-directed throughout the bulge in all the models, regardless of size. Vortices appeared in the bulge initially during deceleration from systole, then expanded during the retrograde flow phase. The complexity of the vortex field depended strongly on bulge diameter. In every model, the maximum shear stress occurred at peak systole at the distal bulge end, with the greatest shear stress developing in a model corresponding to a 4.3 cm AAA in vivo. Although the smallest models exhibited stable flow throughout the cycle, flow in the larger models became increasingly unstable as bulge size increased, with strong amplification of instability in the distal half of the bulge. These data suggest that larger aneurysms in vivo may be subject to more frequent and intense turbulence than smaller aneurysms. Concomitantly, increased turbulence may contribute significantly to wall stress magnitude and thereby to risk of rupture.

scholarly journals Peak wall stress measurement in elective and acute abdominal aortic aneurysms

2008 ◽  
Vol 47 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Michael S. Heng ◽  
Michael J. Fagan ◽  
Jason W. Collier ◽  
Grishma Desai ◽  
Peter T. McCollum ◽  
...  
Keyword(s):  
Stress Measurement ◽  
Wall Stress ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Abdominal Aortic ◽  
Peak Wall Stress

Wall Stress Reduction in Abdominal Aortic Aneurysms as a Result of Polymeric Endoaortic Paving

2011 ◽  
Vol 39 (6) ◽  
pp. 1680-1689 ◽  
Author(s):  
John H. Ashton ◽  
Avinash Ayyalasomayajula ◽  
Bruce R. Simon ◽  
Jonathan P. Vande Geest
Keyword(s):  
Stress Reduction ◽  
Wall Stress ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Abdominal Aortic

A decoupled fluid structure approach for estimating wall stress in abdominal aortic aneurysms

2007 ◽  
Vol 40 (2) ◽  
pp. 367-377 ◽  
Author(s):  
Yannis Papaharilaou ◽  
John A. Ekaterinaris ◽  
Eirini Manousaki ◽  
Asterios N. Katsamouris
Keyword(s):  
Wall Stress ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Structure Approach ◽  
Fluid Structure ◽  
Abdominal Aortic

scholarly journals Increased expression of Lamin A/C correlates with regions of high wall-stress in abdominal aortic aneurysms.

Aorta ◽  
2016 ◽  
Vol 3 (5) ◽  
pp. 152-166 ◽  
Author(s):  
Amir Malkawi ◽  
Grisha Pirianov ◽  
Evelyn Torsney ◽  
Ian Chetter ◽  
Natzi Sakalihasan ◽  
...  
Keyword(s):  
Wall Stress ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Lamin A ◽  
Abdominal Aortic

Local Mechanical Properties of Abdominal Aortic Aneurysms

2008 ◽  
Author(s):  
Evelyne van Dam ◽  
Marcel Rutten ◽  
Frans van de Vosse
Keyword(s):  
Mechanical Properties ◽  
Stress Analysis ◽  
Vessel Wall ◽  
Computational Models ◽  
Wall Stress ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Patient Specific ◽  
Rupture Risk ◽  
Abdominal Aortic

Rupture risk of abdominal aortic aneurysms (AAA) based on wall stress analysis may be superior to the currently used diameter-based rupture risk prediction [4; 5; 6; 7]. In patient specific computational models for wall stress analysis, the geometry of the aneurysm is obtained from CT or MR images. The wall thickness and mechanical properties are mostly assumed to be homogeneous. The pathological AAA vessel wall may contain collageneous areas, but also calcifications, cholesterol crystals and large amounts of fat cells. No research has yet focused yet on the differences in mechanical properties of the components present within the degrading AAA vessel wall.

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