scholarly journals Skeletal Muscle Adaptation in Response to Supervised Exercise Training for Intermittent Claudication

2012 ◽  
Vol 44 (3) ◽  
pp. 313-317 ◽  
Author(s):  
T.A. Beckitt ◽  
J. Day ◽  
M. Morgan ◽  
P.M. Lamont
Keyword(s):  
Skeletal Muscle ◽  
Exercise Training ◽  
Intermittent Claudication ◽  
Muscle Adaptation ◽  
Supervised Exercise

scholarly journals Supervised Exercise Training for Intermittent Claudication: Lasting Benefit at Three Years

2007 ◽  
Vol 34 (3) ◽  
pp. 322-326 ◽  
Author(s):  
D.A. Ratliff ◽  
M. Puttick ◽  
G. Libertiny ◽  
R.C.J. Hicks ◽  
L.E. Earby ◽  
...  
Keyword(s):  
Exercise Training ◽  
Intermittent Claudication ◽  
Supervised Exercise

scholarly journals Supervised Exercise Training for Intermittent Claudication: Lasting Benefit at Three Years

2007 ◽  
Vol 46 (3) ◽  
pp. 611
Author(s):  
D.A. Ratliff ◽  
M. Puttick ◽  
G. Libertiny ◽  
R.C.J. Hicks ◽  
L.E. Earby ◽  
...  
Keyword(s):  
Exercise Training ◽  
Intermittent Claudication ◽  
Supervised Exercise

scholarly journals Impairment of microcirculation and energy metabolism in intermittent claudication: beneficial effects of exercise training

2016 ◽  
Vol 72 (3) ◽  
Author(s):  
Eugenio Laurenzano ◽  
Lucrezia Spadera ◽  
Mario De Laurentis ◽  
Gregorio Brevetti
Keyword(s):  
Skeletal Muscle ◽  
Energy Metabolism ◽  
Exercise Training ◽  
Intermittent Claudication ◽  
Large Body ◽  
Arterial Disease ◽  
Walking Ability ◽  
Beneficial Effects ◽  
Relevant Role ◽  
Peripheral Arterial

Although in peripheral arterial disease (PAD) the primary determinant of inadequate blood supply to the affected limb during exercise is a flow-limiting lesion of a conduit artery, there is a large body of evidence that impairment of microcirculation and skeletal muscle energy metabolism play a relevant role in the reduced working ability of affected individuals. This review was conceived to cast some light on this topic, paying special attention to the functional benefits of exercise training (ET) in the treatment of claudicant patients. In PAD, the ischemia induced by maximal exercise increases oxidative stress, inflammation and endothelial dysfunction. Perturbation of the endothelial homeostasis results in increased adhesiveness of leukocytes and platelets, and in reduced vasodilator capability. These events, expression of the interplay between inflammation and endothelium, provoke an obstacle in the microcirculation with a reduction in the nutritive blood flow, leading to acidosis and impaired energy metabolism in skeletal muscle, with consequent reduced exercise tolerance. ET counteracts these effects by improving walking ability and quality of life in patients with intermittent claudication, thus representing the gold standard in the treatment of PAD.

scholarly journals Histone Modification: A Mechanism for Regulating Skeletal Muscle Characteristics and Adaptive Changes

2021 ◽  
Vol 11 (9) ◽  
pp. 3905
Author(s):  
Fuminori Kawano
Keyword(s):  
Skeletal Muscle ◽  
Exercise Training ◽  
Histone Modification ◽  
Histone Modifications ◽  
Satellite Cells ◽  
Skeletal Muscles ◽  
Critical Role ◽  
Cell Lineage ◽  
Muscle Adaptation ◽  
Adaptive Changes

Epigenetics is getting increased attention in the analysis of skeletal muscle adaptation to physiological stimuli. In this review, histone modifications in skeletal muscles and their role in the regulation of muscle characteristics and adaptive changes are highlighted. The distribution of active histone modifications, such as H3K4me3 and H3 acetylation, largely differs between fast- and slow-twitch muscles. It is also indicated that the transcriptional activity in response to exercise differs in these muscle types. Histone turnover activated by exercise training leads to loosening of nucleosomes, which drastically enhances gene responsiveness to exercise, indicating that the exercise training transforms the chromatin structure to an active status. Furthermore, histone modifications play a critical role in preserving the stem cell lineage in skeletal muscle. Lack of lysine-specific demethylase 1 in satellite cells promotes the differentiation into brown adipocytes during muscle regeneration after injury. H4K20me2, which promotes the formation of heterochromatin, is necessary to repress MyoD expression in the satellite cells. These observations indicate that histone modification is a platform that characterizes skeletal muscles and may be one of the factors regulating the range of adaptive changes in these muscles.

Long-term effects of supervised exercise training on walking capacity and quality of life in patients with intermittent claudication

VASA ◽  
2008 ◽  
Vol 37 (3) ◽  
pp. 250-256 ◽  
Author(s):  
Keo ◽  
Grob ◽  
Guggisberg ◽  
Widmer ◽  
Baumgartner ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Exercise Training ◽  
Intermittent Claudication ◽  
Long Term Effects ◽  
Supervised Exercise ◽  
Exercise Training Program ◽  
Walking Capacity

Supervised exercise training has been shown to improve walking capacity in several studies of patients with intermittent claudication. However, data on long-term outcome are quite limited. The aim of this prospective study was to evaluate long-term effects of supervised exercise training on walking capacity and quality of life in patients with intermittent claudication. Patients and methods: Sixty-seven consecutive patients with intermittent claudication who completed a supervised 12-week exercise training program were asked for follow up evaluation 39 ± 20 months after program completion. Pain-free walking distance (PWD) and maximum walking distances (MWD) were assessed by treadmill test and several questionnaires. Results: Forty (60%) patients agreed to participate, 22 (33%) refused participation, and 5 (7%) died during follow-up. PWD and MWD significantly improved at completion of 12-weeks supervised exercise training as compared to baseline (PWD 114 ± 100 vs. 235 ± 248, p = 0.002; MWD 297 ± 273 vs. 474 ± 359, p = 0.001). Improvement of PWD and MWD could be maintained at follow up (197 ± 254, p = 0.014; 390 ± 324, p = 0.035, respectively) with non-smokers showing significantly better sustained PWD and MWD improvement as compared to baseline. Overall, walking capacity correlated with functional status of quality of life. Conclusions: Major findings of this investigation were that improvement in walking capacity is sustained after completion of supervised exercise training program with best results in patients who quitted or never smoked. Improved walking capacity is associated with increased functional status of quality of life.

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