Functional and Oncological Outcomes After Transanal Local Excision for Rectal Cancer. A Prospective Study

2011 ◽  
Vol 37 (12) ◽  
pp. S4
Author(s):  
G. Luglio ◽  
V. Celentano ◽  
R. Tarquini ◽  
V. Sollazzo ◽  
M.C. Giglio ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Prospective Study ◽  
Local Excision ◽  
Transanal Local Excision ◽  
Oncological Outcomes ◽  
A Prospective Study

Can We Predict Complete or Major Response after Chemoradiotherapy for Rectal Cancer by Noninvasive Methods? Results of a Prospective Study on 61 Patients

2014 ◽  
Vol 80 (11) ◽  
pp. 1136-1145 ◽  
Author(s):  
David Moszkowicz ◽  
FréDéRique Peschaud ◽  
Mostafa El Hajjam ◽  
Catherine Julié ◽  
Alain Beauchet ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Prospective Study ◽  
Digital Rectal Examination ◽  
Radical Resection ◽  
Complete Response ◽  
Pathological Examination ◽  
Noninvasive Methods ◽  
Predictive Values ◽  
Major Response ◽  
A Prospective Study

Rectal preservation has been proposed as an alternative to radical resection in patients with presumed complete or major response to chemoradiotherapy (CRT). The aim of this prospective study was to evaluate the accuracy of digital rectal examination (DRE) and magnetic resonance imaging (MRI) to predict major or complete rectal cancer response to CRT. Over 2 years, 61 patients underwent radical resection after CRT for rectal cancer. DRE and MRI were carried out before and 6 to 8 weeks after the end of CRT. Data from DRE and MRI post-CRT were compared with pathological examinations. At pathological examination, major/complete responses were recorded for tumors classified ypT1N0 and ypT0N0, respectively. DRE post-CRT showed major/complete response in 26 cases, of which 14 (54%) were confirmed by pathology. The positive (PPV) and negative (NPV) predictive values of DRE to predict major/complete response were 54 and 88 per cent, respectively. MRI post-CRT showed major/complete response in 12 cases, of which nine (75%) were confirmed by pathology. The PPV and NPV of MRI to predict major/complete response were 75 and 82 per cent, respectively. Data from DRE and RMI post-CRT were concordant in 45 patients. The PPV and NPV of concordant DRE and MRI to predict major/complete response were 82 and 91 per cent, respectively. DRE and MRI do not appear to be sufficiently accurate for safe selection of patients appropriate for a rectum-sparing strategy because the risk of leaving an invasive tumor untreated is 18 per cent.

How important is peritoneal involvement in rectal cancer? A prospective study of 331 cases

2010 ◽  
Vol 57 (5) ◽  
pp. 671-679 ◽  
Author(s):  
John R Mitchard ◽  
Sharon B Love ◽  
Karol J Baxter ◽  
Neil A Shepherd
Keyword(s):  
Rectal Cancer ◽  
Prospective Study ◽  
A Prospective Study

Transanal Local Excision for Distal Rectal Cancer and Incomplete Response to Neoadjuvant Chemoradiation – Does Baseline Staging Matter?

2014 ◽  
Vol 57 (11) ◽  
pp. 1253-1259 ◽  
Author(s):  
Rodrigo O. Perez ◽  
Angelita Habr-Gama ◽  
Guilherme P. São Julião ◽  
Igor Proscurshim ◽  
Augusto Q. Coelho ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Local Excision ◽  
Neoadjuvant Chemoradiation ◽  
Transanal Local Excision ◽  
Incomplete Response ◽  
Distal Rectal Cancer ◽  
Baseline Staging

scholarly journals Local Excision and Endoscopic Resections for Early Rectal Cancer

2017 ◽  
Vol 30 (05) ◽  
pp. 313-323 ◽  
Author(s):  
Juan Celentano ◽  
Flavia Alexandre ◽  
Bruna Vailati ◽  
Guilherme São Julião
Keyword(s):  
Rectal Cancer ◽  
Local Excision ◽  
Standard Treatment ◽  
Diagnostic Tools ◽  
Transanal Local Excision ◽  
Rectal Cancers ◽  
Endoscopic Microsurgery ◽  
Poor Outcomes ◽  
Interesting Alternative ◽  
The Ideal

AbstractRadical surgery is considered as the standard treatment for rectal cancer. Transanal local excision has been considered an interesting alternative for the management of selected patients with rectal cancers for many decades. Different approaches had been considered for local excision, from endoscopic submucosal dissection to resections using platforms, such as transanal endoscopic microsurgery or transanal minimally invasive surgery. Identifying the ideal candidate for this approach is crucial, as a local failure after local excision is associated with poor outcomes, even for an initial early rectal tumor. In this article, the diagnostic tools and criteria to select patients for local excision, the different modalities used, and the outcomes are discussed.

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