Factors predictive of breast cancer in open biopsy in cases with atypical ductal hyperplasia diagnosed by ultrasound-guided core needle biopsy

2011 ◽  
Vol 37 (9) ◽  
pp. 758-764 ◽  
Author(s):  
Z.-J. Hong ◽  
C.-H. Chu ◽  
H.-L. Fan ◽  
H.-M. Hsu ◽  
C.-J. Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Atypical Ductal Hyperplasia ◽  
Ultrasound Guided ◽  
Open Biopsy ◽  
Core Needle ◽  
Ductal Hyperplasia

scholarly journals Atypical Ductal Hyperplasia of the Breast on Core Needle Biopsy - Risk of Malignant Upgrade on Surgical Excision.

2021 ◽  
Author(s):  
Tiffany Sin Hui Bong ◽  
Thaddaeus Tan ◽  
Juliana TS Ho ◽  
Puay Hoon Tan ◽  
Wing Sze Lau ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Atypical Ductal Hyperplasia ◽  
Surgical Excision ◽  
Hazard Ratio ◽  
Low Risk ◽  
Good Discrimination ◽  
Core Needle ◽  
Ductal Hyperplasia

Abstract Purpose: Atypical ductal hyperplasia (ADH) is a high risk lesion with an increased risk of developing breast cancer. This study aims to identify factors predictive of malignant upgrade for ADH diagnosed on core needle biopsy (CNB) and to develop a nomogram to facilitate evidence-based decision making.Methods: Retrospective analysis of women with CNB diagnosed ADH at the National Cancer Centre Singapore between 2010 and 2015 was performed. Cox proportional hazards regression was used to identify independent clinical, radiological and histological factors associated with malignant upgrade. A nomogram was constructed and multivariable logistic regression coefficients were used to estimate the predicted probability of upgrade for each factor combination. Combinations with the lowest predicted probabilities (≤5%) were identified as low risk. Model sensitivity, specificity, positive and negative predictive values were assessed.Results: From 2010-2015, 238,122 women underwent screening under the national breast cancer screening programme. 29,564 women were recalled and 5742 CNBs were performed, of which 2686 were performed at NCCS. 88 patients (90 lesions) were diagnosed with ADH. 26 lesions were upgraded to a breast malignancy on excision biopsy. On univariate analysis, presence of a mass on either ultrasound (p= 0.018) or mammogram (p=0.026), presence of mammographic microcalcifications (p=0.047), diffuse microcalcification distribution (p=0.034), mammographic parenchymal density (p=0.008), presence of microcalcifications on biopsy (p=0.037) and three or more separate foci of ADH found on biopsy (p=0.024) were associated with malignant upgrade. Mammographic parenchymal density (Hazard ratio= 0.04, 95% CI 0.005-0.35, p=0.014), presence of a mass on ultrasound (Hazard ratio= 10.50, 95% CI 9.21-25.2, p=0.010) and number of foci of ADH (Hazard ratio = 1.877, 95% CI 1.831-1.920, p=0.002) remained significant on multivariate analysis and were included in the normogram which demonstrated good discrimination with C-statistic of 0.81 [95% CI, 0.74 to 0.88].Conclusion: Our model provides good discrimination of breast cancer risk prediction in patients with ADH on CNB. A subset of women at low risk (<5%) of upgrade to cancer may avoid surgical excision following a core-needle biopsy diagnosis of ADH.

Is bigger better? Twenty-year institutional experience of atypical ductal hyperplasia discovered by core needle biopsy

2019 ◽  
Vol 217 (5) ◽  
pp. 906-909 ◽  
Author(s):  
Jessica B. Weiss ◽  
Woo S. Do ◽  
Dominic M. Forte ◽  
Rowan R. Sheldon ◽  
Charles K. Childers ◽  
...  
Keyword(s):  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Atypical Ductal Hyperplasia ◽  
Core Needle ◽  
Ductal Hyperplasia ◽  
Institutional Experience

Preoperative staging of axillary lymph nodes in breast cancer: Ultrasonographic parameters and ultrasound-guided core needle biopsy

2011 ◽  
Vol 53 (6) ◽  
pp. 544-551
Author(s):  
M.Y. Torres Sousa ◽  
M.E. Banegas Illescas ◽  
M.L. Rozas Rodríguez ◽  
M. Arias Ortega ◽  
L.M. González López ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Preoperative Staging ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Ultrasound Guided ◽  
Core Needle

Atypical Ductal Hyperplasia Diagnosed at Sonographically Guided Core Needle Biopsy: Frequency, Final Surgical Outcome, and Factors Associated With Underestimation

2014 ◽  
Vol 202 (6) ◽  
pp. 1389-1394 ◽  
Author(s):  
Benoît Mesurolle ◽  
Juan Carlos Hidalgo Perez ◽  
Fahad Azzumea ◽  
Emmanuelle Lemercier ◽  
Xuanqian Xie ◽  
...  
Keyword(s):  
Core Needle Biopsy ◽  
Surgical Outcome ◽  
Needle Biopsy ◽  
Atypical Ductal Hyperplasia ◽  
Core Needle ◽  
Factors Associated ◽  
Ductal Hyperplasia
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