Molecular profiling techniques and bioinformatics in cancer research

2007 ◽  
Vol 33 (3) ◽  
pp. 255-265 ◽  
Author(s):  
A.T. Manning ◽  
J.T. Garvin ◽  
R.I. Shahbazi ◽  
N. Miller ◽  
R.E. McNeill ◽  
...  
Keyword(s):  
Cancer Research ◽  
Molecular Profiling ◽  
Profiling Techniques

Detection of breast cancer-related antigens through cDNA phage-displayed protein microarray

2010 ◽  
Vol 391 (7) ◽  
Author(s):  
Qun Bi ◽  
Taochao Tan ◽  
Xi Xiang ◽  
Aiping Lu ◽  
Shenggeng Zhu
Keyword(s):  
Breast Cancer ◽  
Cancer Research ◽  
High Throughput ◽  
Breast Tumor ◽  
Protein Microarray ◽  
Molecular Profiling ◽  
Multifactorial Disease ◽  
Cdna Sequences ◽  
Profiling Techniques ◽  
Related Proteins

AbstractHigh-throughput molecular profiling techniques are helpful in the diagnosis of multifactorial disease. In this study, a cDNA-phage-displayed protein microarray using phage particles spotted directly onto it as sensors was used to detect related antigens in breast tumor sera. cDNA sequences from 17 positive clones were determined, which included some sequences encoding known breast cancer-related antigens and proteins related to other diseases, as well as proteins with unknown functions. Our results not only provide some useful information for breast cancer research, but also suggest that the strategy used here would be efficient to search for disease-related proteins and other functional target proteins.

Molecular profiling in cancer research and personalized medicine

2019 ◽  
pp. 347-362
Author(s):  
Pieter-Jan van Dam ◽  
Steven Van Laere
Keyword(s):  
Personalized Medicine ◽  
High Throughput ◽  
Cancer Biology ◽  
Complex Disease ◽  
Human Cancer ◽  
Molecular Profiling ◽  
Cancer Genome ◽  
The Cancer Genome Atlas ◽  
Molecular Heterogeneity ◽  
Profiling Techniques

Recent efforts by worldwide consortia such as The Cancer Genome Atlas and the International Cancer Genome Consortium have greatly accelerated our knowledge of human cancer biology. Nowadays, complete sets of human tumours that have been characterized at the genomic, epigenomic, transcriptomic, or proteomic level are available to the research community. The generation of these data was made possible thanks to the application of high-throughput molecular profiling techniques such as microarrays and next-generation sequencing. The primary conclusion from current profiling experiments is that human cancer is a complex disease characterized by extreme molecular heterogeneity, both between and within the classical, tissue-defined cancer types. This molecular variety necessitates a paradigm shift in patient management, away from generalized therapy schemes and towards more personalized treatments. This chapter provides an overview of how molecular cancer profiling can assist in facilitating this transition. First, the state-of-the-art of molecular breast cancer profiling is reviewed to provide a general background. Then, the most pertinent high-throughput molecular profiling techniques along with various data mining techniques (i.e. unsupervised clustering, statistical learning) are discussed. Finally, the challenges and perspectives with respect to molecular cancer profiling, also from the perspective of personalized medicine, are summarized.

scholarly journals The US–Latin America Cancer Research Network

2020 ◽  
Vol 6 (Supplement_1) ◽  
pp. 56-56
Author(s):  
Vidya Vedham ◽  
Marianne K. Henderson ◽  
Osvaldo Podhajcer ◽  
Andrea Llera ◽  
Marisa Dreyer Breitenbach ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Research ◽  
Latin America ◽  
Clinical Research ◽  
Latin American ◽  
Molecular Profiling ◽  
Research Network ◽  
Research Institutions ◽  
Cancer Research Network ◽  
The Us

PURPOSE The National Cancer Institute (NCI) Center for Global Health promotes global oncology research to reduce cancer burden worldwide. In 2009, NCI launched the Latin American Cancer Research Network (LACRN) to support a clinical cancer research network in Latin America. LACRN was started by a coalition of research institutions through bilateral collaborative agreements between the US Department of Health and Human Services and the governments of Argentina, Brazil, Chile, Mexico, and Uruguay. The LACRN is supported through a research contract to a study coordination center and subcontracts to 6 low- and middle-income country sites. The participating countries have a shared goal that meets the specific research needs of the regions. The overarching purpose of this endeavor is to implement high-quality standards for conducting clinical research studies and developing collaborative cancer research projects. METHODS NCI supported a clinical breast cancer project for LACRN, “Molecular profiling of breast cancer (MPBC) in Latin American women with stage II and III breast cancer receiving standard neo-adjuvant chemotherapy.” The molecular profiling of breast cancer study was conducted in 40 hospitals and research institutions across 5 countries with a study population of approximately 1,400 patients. RESULTS AND CONCLUSION Establishing a comprehensive network in Latin America and their research institutions yielded an incredible research resource that can be used in future studies, driven by the network. Throughout the process of developing and implementing studies, LACRN helped identify key elements of the functionality of research networks, such as the pivotal role of institutional and government commitment for sustainability; the importance of building multidisciplinary teams, transparent communications, and training; the ability to combine translational, epidemiology, and clinical research to close research gaps; and the application of new technologies to standard cancer clinical care.

Exploitation of molecular profiling techniques for GM food safety assessment

2003 ◽  
Vol 14 (2) ◽  
pp. 238-243 ◽  
Author(s):  
Harry A Kuiper ◽  
Esther J Kok ◽  
Karl-Heinz Engel
Keyword(s):  
Food Safety ◽  
Safety Assessment ◽  
Molecular Profiling ◽  
Gm Food ◽  
Profiling Techniques

scholarly journals Cellular identity at the single-cell level

2016 ◽  
Vol 12 (10) ◽  
pp. 2965-2979 ◽  
Author(s):  
Ahmet F. Coskun ◽  
Umut Eser ◽  
Saiful Islam
Keyword(s):  
Identity Formation ◽  
Single Cell ◽  
Molecular Profiling ◽  
Single Cell Level ◽  
Cell Level ◽  
Profiling Techniques ◽  
Health And Disease ◽  
Cellular Identity

Single cell molecular profiling techniques decode cellular identity formation within developing complex tissues and organs in both health and disease.

A Hopeful Discovery in Cancer Research

1949 ◽  
Vol 12 (4) ◽  
pp. 700-701
Author(s):  
W.C.A.
Keyword(s):  
Cancer Research
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