Abnormality of the infrapatellar fat pad (Hoffa's fat pad) in a patient with HIV: MR findings with histological correlation

2008 ◽  
Vol 68 (1) ◽  
pp. 29-32 ◽  
Author(s):  
Etienne Pluot ◽  
Jaspreet Singh ◽  
Steven Laurence Joseph James ◽  
Arthur Mark Davies ◽  
Vaiyapuri Palaniappan Sumathi ◽  
...  
Keyword(s):  
Infrapatellar Fat Pad ◽  
Fat Pad ◽  
Hoffa’S Fat Pad

scholarly journals Phosphorus Concentration in Knee Joint Structures of Patients Following Replacement Surgery

2019 ◽  
Vol 16 (4) ◽  
pp. 525 ◽  
Author(s):  
Ciosek Żaneta ◽  
Kosik-Bogacka Danuta ◽  
Łanocha-Arendarczyk Natalia ◽  
Kot Karolina ◽  
Karaczun Maciej ◽  
...  
Keyword(s):  
Knee Joint ◽  
Cruciate Ligament ◽  
The Body ◽  
Infrapatellar Fat Pad ◽  
Emission Spectrometry ◽  
Phosphorus Concentration ◽  
Spongy Bone ◽  
Fat Pad ◽  
Hoffa’S Fat Pad ◽  
P Concentration

The aim of the study was to assess phosphorus (P) concentration in structures of the knee joint—including the tibial spongy bone, articular cartilage, meniscus, anterior cruciate ligament, and infrapatellar fat pad (Hoffa’s fat pad)—of patients following knee joint replacement. The study also aimed to assess the influence of selected biological and environmental factors on P concentration in studied parts of the knee joint. Phosphorus concentration was determined using inductively coupled plasma-atomic emission spectrometry (ICP-AES). Statistically significant differences in P concentration were found between different elements of the knee joint. The highest P concentration was measured in the spongy bone (72,746.68 mg kg−1 dw) and the lowest in the Hoffa’s fat pad (1203.19 mg kg−1 dw). P levels were unaffected by gender, age, BMI, place of residence, smoking, or alcohol consumption. Data on P concentration in the osteoarticular elements of the knee may be useful in the interpretation and evaluation of biochemical, morphological, and mechanical changes occurring in the body.

scholarly journals Fibrolipoma with Osseous and Cartilaginous Metaplasia of Hoffa’s Fat Pad: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
Ioannis Gigis ◽  
Panagiotis Gigis
Keyword(s):  
Functional Limitations ◽  
Infrapatellar Fat Pad ◽  
Benign Tumors ◽  
Fat Pad ◽  
Soft Mass ◽  
Hoffa’S Fat Pad ◽  
Chondroid Metaplasia ◽  
One Year ◽  
The Right ◽  
Sixth Decade

The most common benign tumors of the mesenchyme are the lipomas. Benign fatty tumors can arise in any location in which fat is present. Fibrolipomas are characterised by fat modules. Most patients affected by such tumors are in the fifth or sixth decade of life. When very close to vital structures such as joints, they may cause functional limitations as well as pain. Osseous and chondroid metaplasia can infrequently manifest after chronic persistence. Given the rarity of this condition, a case of a big fibrolipoma of Hoffa’s fat pad with osseous and cartilaginous metaplasia is reported. A 44-year-old woman presented with an enlarging soft mass on the right knee in the infrapatellar fat pad. After a thorough preoperative clinical and imaging examination, the mass was removed and sent to laboratory where the diagnosis was put. One year after surgery, both local and general condition of the patient were good and no signs of recurrence were found.

scholarly journals Giant Intra-Articular Extrasynovial Osteochondroma of the Knee: A Report of Two Cases

2011 ◽  
Vol 5 (1) ◽  
pp. 368-371 ◽  
Author(s):  
F De Maio ◽  
S Bisicchia ◽  
V Potenza ◽  
R Caterini ◽  
P Farsetti
Keyword(s):  
Range Of Motion ◽  
Anterior Part ◽  
Complete Recovery ◽  
Infrapatellar Fat Pad ◽  
Fat Pad ◽  
Hoffa’S Fat Pad ◽  
Longitudinal Approach ◽  
Bone Trabeculae ◽  
Inner Region

We report two cases of a giant extrasynovial osteochondroma of the knee located in the infrapatellar fat pad region, in two females who were 58 and 71 years old respectively. Both patients had noticed the mass many years before our first clinical observation. In both patients, at physical examination a solid, firm and hard mass was palpable in the anterior part of the knee in Hoffa’s fat pad region, and the range of motion of the knee was severely restricted and painful. CT scan examination with 3D-reconstruction showed two large, calcified neoformations behind the patellar tendon, between the apex of the patella and the proximal third of the tibia. In both cases, the mass was completely resected surgically through an anterior longitudinal approach. At histological examination, the excised masses consisted of an outer layer of hyaline cartilage without significant chondrocyte atypia and an inner region of bone trabeculae formed by endochondral ossification. At follow-up, 8 and 4 years after the operation, both patients were pain-free, with complete recovery of the range of motion of the knee and without any clinical or radiographic evidence of recurrence. The authors believe that intra-articular extrasynovial osteochondroma of the knee is a primary metaplasia of Hoffa’s fat pad. Usually, the tumor develops slowly and asymptomatically over many years. The treatment of choice is a marginal resection of the mass, although a biopsy should be considered in some cases. Recurrences are extremely rare.

scholarly journals Unusual presentation of giant ganglion cyst from the infrapatellar (Hoffa’s) fat pad of knee: a case report

2020 ◽  
Vol 7 (1) ◽  
pp. 153
Author(s):  
A. M. Shantha kumar ◽  
Santosh Sahanand ◽  
David V. Rajan
Keyword(s):  
Case Report ◽  
Knee Joint ◽  
Patellar Tendon ◽  
Treatment Option ◽  
Ganglion Cyst ◽  
Posterior Wall ◽  
Infrapatellar Fat Pad ◽  
Fat Pad ◽  
Hoffa’S Fat Pad ◽  
Open Excision

<p>Ganglion cyst of the knee joint can be intra articular or extra articular. Large intra articular ganglionic cystic formations arising from the infrapatellar fat pad are quite uncommon and only few are reported. Treatment option is surgery(open/arthroscopic) depending on the site and size of the cyst. We report a case of giant ganglion cyst arising from the infra patellar Hoffa's fat pad which presents anterior to the patellar tendon through a rent in the medial retinaculum with the posterior wall of the cyst being adherent to the para tenon of the patellar tendon, in a 58 year old male which presents anterior to the patellar tendon through a rent in the patellar retinaculum which was adherent to the para tenon of the patellar tendon and it was managed by open excision of the cyst.</p><p> </p>

scholarly journals The clinical efficacy of arthroscopic therapy with knee infrapatellar fat pad cell concentrates in treating knee cartilage lesion: a prospective, randomized, and controlled study

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Yiqin Zhou ◽  
Haobo Li ◽  
Dong Xiang ◽  
Jiahua Shao ◽  
Qiwei Fu ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Knee Arthroscopy ◽  
Infrapatellar Fat Pad ◽  
Control Group ◽  
Knee Cartilage ◽  
Fat Pad ◽  
Group 12 ◽  
Significant Difference

Abstract Introduction To evaluate the clinical efficacy of arthroscopic therapy with infrapatellar fat pad cell concentrates in treating knee cartilage lesions, we conducted a prospective randomized single-blind clinical study of controlled method. Methods Sixty cases from Shanghai Changzheng Hospital from April 2018 to December 2019 were chosen and randomly divided into 2 groups equally. Patients in the experiment group were treated through knee arthroscopy with knee infrapatellar fat pad cell concentrates containing mesenchymal stromal cells, while patients in the control group were treated through regular knee arthroscopic therapy. VAS and WOMAC scores were assessed at pre-operation, and 6 weeks, 12 weeks, 6 months, and 12 months after intervention. MORCART scores were assessed at pre-operation and 12 months after intervention. Results Twenty-nine cases in the experiment group and 28 cases in the control group were followed up. No significant difference in VAS, WOMAC, and MOCART scores were found between the two groups before surgery (P > 0.05). The WOMAC total and WOMAC function scores of the experiment group were significantly lower than those of the control group 6 months and 12 months after surgery (P < 0.05). The VAS rest and VAS motion scores of the experiment group were found significantly lower than those of the control group 12 months after surgery (P < 0.05). The MOCART scores of the experiment group were found significantly higher compared with the control group 12 months after surgery (P < 0.05). No significant difference in WOMAC stiffness scores were found between the two groups. Conclusions The short-term results of our study are encouraging and demonstrate that knee arthroscopy with infrapatellar fat pad cell concentrates containing mesenchymal stromal cells is safe and provides assistance in reducing pain and improving function in patients with knee cartilage lesions. Trial registration ChiCTR1800015379. Registered on 27 March 2018, http://www.chictr.org.cn/showproj.aspx?proj=25901.

Hypoxic Preconditioning Induces Neuronal Differentiation of Infrapatellar Fat Pad Stem Cells through Epigenetic Alteration

2021 ◽  
Vol 12 (4) ◽  
pp. 704-718
Author(s):  
Subathra Radhakrishnan ◽  
Catherine Ann Martin ◽  
Geethanjali Dhayanithy ◽  
Mettu Srinivas Reddy ◽  
Mohamed Rela ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neuronal Differentiation ◽  
Hypoxic Preconditioning ◽  
Infrapatellar Fat Pad ◽  
Fat Pad ◽  
Epigenetic Alteration

scholarly journals FRI0416 COMBINATION OF SERUM ADIPOKINES/RELATED INFLAMMATORY FACTORS AND RATIOS AS PREDICTORS OF INFRAPATELLAR FAT PAD VOLUME IN KNEE OSTEOARTHRITIS PATIENTS: USAGE OF A COMPREHENSIVE MACHINE LEARNING APPROACH

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 806.1-807
Author(s):  
H. Bonakdari ◽  
G. Tardif ◽  
F. Abram ◽  
J. P. Pelletier ◽  
J. Martel-Pelletier
Keyword(s):  
Risk Factors ◽  
Serum Levels ◽  
Infrapatellar Fat Pad ◽  
Inflammatory Factors ◽  
Fat Pad ◽  
Research Support ◽  
Knee Oa ◽  
Total Cohort ◽  
Low Bmi ◽  
The University

Background:One of the hurdles in osteoarthritis (OA) drug discovery and the improvement of therapeutic approaches is the early identification of patients who will progress. It is therefore crucial to find efficient and reliable means of screening OA progressors. Although the main risk factors, age, gender and body mass index (BMI), are important, they alone are poor predictors. However, serum factors could be potential biomarkers for early prediction of knee OA progression.Objectives:In a first step toward finding early reliable predictors of OA progressors, this study aimed to determine, in OA individuals, the optimum combination of serum levels of adipokines/related inflammatory factors, their ratios, and the three main OA risk factors for predicting knee OA infrapatellar fat pad (IPFP) volume, as this tissue has been associated with knee OA onset and progression.Methods:Serum and magnetic resonance images (MRI) were from the Osteoarthritis Initiative at baseline. Variables (48) comprised the 3 main OA risk factors (age, gender, BMI), 6 adipokines, 3 inflammatory factors, and their 36 ratios. IPFP volume was assessed on MRI with a neural network methodology. The best variables and models were identified in Total cohort (n=678), High-BMI (n=341) and Low-BMI (n=337), using an artificial intelligence selection approach: the adaptive neuro-fuzzy inference system embedded with fuzzy c-means clustering (ANFIS-FCM). Performance was validated using uncertainty analyses and statistical indices. Reproducibility was done using 80 OA patients from a clinical trial (female, n=57; male, n=23).Results:For the three groups, 8.44E+14 sub-variables were investigated and 48 models were selected. The best model for each group included five variables: the three risk factors and adipsin/C-reactive protein combined for Total cohort, adipsin/chemerin; High-BMI, chemerin/adiponectin high molecular weight; and Low-BMI, interleukin-8. Data also revealed that the main form of the ratio used for the model was justified, as the use of the inverse form slightly decreased the performance of the model in both training and testing stages. Further investigation indicated that gender improved (13-16%) the prediction results compared to the BMI-based models. For each gender, we then generated a pseudocode (an evolutionary computation equation) with the 5 variables for predicting IPFP volume. Reproducibility experiments were excellent (correlation coefficient: female 0.83, male 0.95).Conclusion:This study demonstrates, for the first time, that the combination of the serum levels of adipokines/inflammatory factors and the three main risk factors of OA could predict IPFP volume with high reproducibility, and superior performance with gender separation. By using the models for each gender and the pseudocodes for OA patients provided in this study, the next step will be to develop a predictive model for OA progressors.Acknowledgments:This work was funded by the Chair in Osteoarthritis of the University of Montreal, the Osteoarthritis Research Unit of the University of Montreal Hospital Research Centre, the Groupe de recherches des maladies rhumatismales du Québec and by ArthroLab Inc., all from Montreal, Quebec, Canada.Disclosure of Interests:Hossein Bonakdari: None declared, Ginette Tardif: None declared, François Abram Employee of: ArthroLab Inc., Jean-Pierre Pelletier Shareholder of: ArthroLab Inc., Grant/research support from: TRB Chemedica, Speakers bureau: TRB Chemedica and Mylan, Johanne Martel-Pelletier Shareholder of: ArthroLab Inc., Grant/research support from: TRB Chemedica

scholarly journals Para-articular chondroma and osteochondroma of the infrapatellar fat pad: a report of three cases

1999 ◽  
Vol 23 (2) ◽  
pp. 114-117 ◽  
Author(s):  
H. Sakai ◽  
K. Tamai ◽  
A. Iwamoto ◽  
K. Saotome
Keyword(s):  
Infrapatellar Fat Pad ◽  
Fat Pad

Multipotent Stromal Cells Derived From the Infrapatellar Fat Pad of the Knee

2003 ◽  
Vol 412 ◽  
pp. 196-212 ◽  
Author(s):  
M. Quinn Wickham ◽  
Geoffrey R. Erickson ◽  
Jeffrey M. Gimble ◽  
T. Parker Vail ◽  
Farshid Guilak
Keyword(s):  
Stromal Cells ◽  
Infrapatellar Fat Pad ◽  
Multipotent Stromal Cells ◽  
Fat Pad
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