Differentiation of intracranial tuberculomas and high grade gliomas using proton MR spectroscopy and diffusion MR imaging

2012 ◽  
Vol 81 (12) ◽  
pp. 4057-4063 ◽  
Author(s):  
Juan Peng ◽  
Yu Ouyang ◽  
Wei-Dong Fang ◽  
Tian-You Luo ◽  
Yong-Mei Li ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Mr Spectroscopy ◽  
High Grade ◽  
Proton Mr Spectroscopy ◽  
Diffusion Mr ◽  
High Grade Gliomas ◽  
And Diffusion ◽  
Diffusion Mr Imaging

scholarly journals Neuroimaging Biomarkers in SCA2 Gene Carriers

2020 ◽  
Vol 21 (3) ◽  
pp. 1020 ◽  
Author(s):  
Mario Mascalchi ◽  
Alessandra Vella
Keyword(s):  
Mr Imaging ◽  
Mr Spectroscopy ◽  
Surrogate Marker ◽  
Emission Tomography ◽  
Olivopontocerebellar Atrophy ◽  
Proton Mr Spectroscopy ◽  
Diffusion Mr ◽  
Gene Carriers ◽  
And Diffusion ◽  
Diffusion Mr Imaging

A variety of Magnetic Resonance (MR) and nuclear medicine (NM) techniques have been used in symptomatic and presymptomatic SCA2 gene carriers to explore, in vivo, the physiopathological biomarkers of the neurological dysfunctions characterizing the associated progressive disease that presents with a cerebellar syndrome, or less frequently, with a levodopa-responsive parkinsonian syndrome. Morphometry performed on T1-weighted images and diffusion MR imaging enable structural and microstructural evaluation of the brain in presymptomatic and symptomatic SCA2 gene carriers, in whom they show the typical pattern of olivopontocerebellar atrophy observed at neuropathological examination. Proton MR spectroscopy reveals, in the pons and cerebellum of SCA2 gene carriers, a more pronounced degree of abnormal neurochemical profile compared to other spinocerebellar ataxias with decreased NAA/Cr and Cho/Cr, increased mi/Cr ratios, and decreased NAA and increased mI concentrations. These neurochemical abnormalities are detectable also in presymtomatic gene carriers. Resting state functional MRI (rsfMRI) demonstrates decreased functional connectivity within the cerebellum and of the cerebellum with fronto-parietal cortices and basal ganglia in symptomatic SCA2 subjects. 18F-fluorodeoxyglucose Positron Emission Tomography (PET) shows a symmetric decrease of the glucose uptake in the cerebellar cortex, the dentate nucleus, the brainstem and the parahippocampal cortex. Single photon emission tomography and PET using several radiotracers have revealed almost symmetric nigrostriatal dopaminergic dysfunction irrespective of clinical signs of parkinsonism which are already present in presymtomatic gene carriers. Longitudinal small size studies have proven that morphometry and diffusion MR imaging can track neurodegeneration in SCA2, and hence serve as progression biomarkers. So far, such a capability has not been reported for proton MR spectroscopy, rsfMRI and NM techniques. A search for the best surrogate marker for future clinical trials represents the current challenge for the neuroimaging community.

Neuroaxonal dystrophy: MR imaging, proton MR spectroscopy, and diffusion MR imaging findings

2006 ◽  
Vol 33 (3) ◽  
pp. 207-208 ◽  
Author(s):  
H. Mutlu ◽  
H.O. Sildiroglu ◽  
G. Sonmez ◽  
E. Ozturk ◽  
E. Kizilkaya
Keyword(s):  
Mr Imaging ◽  
Mr Spectroscopy ◽  
Neuroaxonal Dystrophy ◽  
Imaging Findings ◽  
Proton Mr Spectroscopy ◽  
Diffusion Mr ◽  
And Diffusion ◽  
Diffusion Mr Imaging

scholarly journals Post-operative perfusion and diffusion MR imaging and tumor progression in high-grade gliomas

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0213905 ◽  
Author(s):  
Matthew L. White ◽  
Yan Zhang ◽  
Fang Yu ◽  
Nicole Shonka ◽  
Michele R. Aizenberg ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Tumor Progression ◽  
High Grade ◽  
Diffusion Mr ◽  
High Grade Gliomas ◽  
And Diffusion ◽  
Diffusion Mr Imaging

scholarly journals Proton MR Spectroscopy and Diffusion MR Imaging Monitoring to Predict Tumor Response to Interstitial Photodynamic Therapy for Glioblastoma

Theranostics ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 436-451 ◽  
Author(s):  
Magali Toussaint ◽  
Sophie Pinel ◽  
Florent Auger ◽  
Nicolas Durieux ◽  
Magalie Thomassin ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mr Imaging ◽  
Mr Spectroscopy ◽  
Tumor Response ◽  
Proton Mr Spectroscopy ◽  
Diffusion Mr ◽  
Interstitial Photodynamic Therapy ◽  
And Diffusion ◽  
Diffusion Mr Imaging

Metachromatic leukodystrophy: Diffusion MR imaging and proton MR spectroscopy

2003 ◽  
Vol 44 (4) ◽  
pp. 440-443 ◽  
Author(s):  
R. N. Sener
Keyword(s):  
Mr Imaging ◽  
Mr Spectroscopy ◽  
Metachromatic Leukodystrophy ◽  
Restricted Diffusion ◽  
High Signal ◽  
Proton Mr Spectroscopy ◽  
Diffusion Mr ◽  
Diffusion Pattern ◽  
Adc Values ◽  
Diffusion Mr Imaging

Metachromatic leukodystrophy is characterized by dysmyelination caused by a deficiency of arylsulfatase-A. In a 17-month-old boy with metachromatic leukodystrophy, an echo-planar diffusion MR sequence revealed a restricted diffusion pattern in the deep white matter, manifested by high-signal on b = 1000 s/mm2 images, and low ADC values (0.56 × 10−3 mm2/s). Proton MR spectroscopy revealed a marked decrease in choline, a metabolite related to myelin turnover. These observations consisting of a restricted diffusion pattern on diffusion MR imaging, and decreased choline peaks on proton spectroscopy, likely represented dysmyelination in metachromatic leukodystrophy.

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