Application of composite dissolving microneedles with high drug loading ratio for rapid local anesthesia

2018 ◽  
Vol 121 ◽  
pp. 330-337 ◽  
Author(s):  
Haohui Zhan ◽  
Fengsen Ma ◽  
Yingcong Huang ◽  
Jie Zhang ◽  
Xiayun Jiang ◽  
...  
Keyword(s):  
Local Anesthesia ◽  
Drug Loading ◽  
High Drug ◽  
Dissolving Microneedles ◽  
Loading Ratio ◽  
High Drug Loading

Phospholipid-mimic oxaliplatin prodrug liposome for treatment of the metastatic triple negative breast cancer

2017 ◽  
Vol 5 (8) ◽  
pp. 1522-1525 ◽  
Author(s):  
Bing Feng ◽  
Fangyuan Zhou ◽  
Wenchao Lu ◽  
Dangge Wang ◽  
Tingting Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Drug Loading ◽  
High Drug ◽  
Loading Ratio ◽  
High Drug Loading

An oxaliplatin prodrug liposome with an extremely high drug loading ratio (>27%) was reported for treatment of triple-negative breast cancer.

Investigating the influence of aromatic moieties on the formulation of hydrophobic natural products and drugs in poly(2-oxazoline) based amphiphiles

2018 ◽  
Author(s):  
Robert Luxenhofer ◽  
Michael M Lübtow ◽  
Lukas Hahn ◽  
Thomas Lorson ◽  
Rainer Schobert
Keyword(s):  
Natural Products ◽  
Small Molecules ◽  
Water Solubility ◽  
Drug Loading ◽  
High Drug ◽  
Long Term Stability ◽  
Aromatic Content ◽  
Important Interaction ◽  
Amorphous Structures ◽  
High Drug Loading

Many natural compounds with interesting biomedical properties share one physicochemical property, namely a low water solubility. Polymer micelles are, among others, a popular means to solubilize hydrophobic compounds. The specific molecular interactions between the polymers and the hydrophobic drugs are diverse and recently it has been discussed that macromolecular engineering can be used to optimize drug loaded micelles. Specifically, π-π stacking between small molecules and polymers has been discussed as an important interaction that can be employed to increase drug loading and formulation stability. Here, we test this hypothesis using four different polymer amphiphiles with varying aromatic content and various natural products that also contain different relative amounts of aromatic moieties. While in the case of paclitaxel, having the lowest relative content of aromatic moieties, the drug loading decreases with increasing relative aromatic amount in the polymer, the drug loading of curcumin, having a much higher relative aromatic content, is increased. Interestingly, the loading using schizandrin A, a dibenzo[a,c]cyclooctadiene lignan with intermediate relative aromatic content is not influenced significantly by the aromatic content of the polymers employed. The very high drug loading, long term stability, the ability to form stable highly loaded binary coformulations in different drug combinations, small sized formulations and amorphous structures in all cases, corroborate earlier reports that poly(2-oxazoline) based micelles exhibit an extraordinarily high drug loading and are promising candidates for further biomedical applications. The presented results underline that the interaction between the polymers and the incorporated small molecules are complex and must be investigated in every specific case.<br>

Design of dual-responsive nanocarries with high drug loading capacity based on hollow mesoporous organosilica nanoparticles

2019 ◽  
Vol 233 ◽  
pp. 230-235 ◽  
Author(s):  
Li-li Lu ◽  
Wen-ya Xiong ◽  
Jun-bin Ma ◽  
Tian-fang Gao ◽  
Si-yuan Peng ◽  
...  
Keyword(s):  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
Dual Responsive ◽  
Mesoporous Organosilica ◽  
High Drug Loading

Cellulose nanocrystals reinforced highly stretchable thermal-sensitive hydrogel with ultra-high drug loading

2021 ◽  
Vol 266 ◽  
pp. 118122
Author(s):  
Tianxing Chen ◽  
Yuan Yang ◽  
Hui Peng ◽  
Andrew K. Whittaker ◽  
Yao Li ◽  
...  
Keyword(s):  
Cellulose Nanocrystals ◽  
Drug Loading ◽  
High Drug ◽  
Highly Stretchable ◽  
High Drug Loading

A novel anhydrous preparation of PEG hydrogels enables high drug loading with biologics for controlled release applications

2021 ◽  
Vol 147 ◽  
pp. 110286
Author(s):  
Christian E. Ziegler ◽  
Moritz Graf ◽  
Sebastian Beck ◽  
Achim M. Goepferich
Keyword(s):  
Controlled Release ◽  
Drug Loading ◽  
Peg Hydrogels ◽  
High Drug ◽  
High Drug Loading

Prodrugs Forming High Drug Loading Multifunctional Nanocapsules for Intracellular Cancer Drug Delivery

2010 ◽  
Vol 132 (12) ◽  
pp. 4259-4265 ◽  
Author(s):  
Youqing Shen ◽  
Erlei Jin ◽  
Bo Zhang ◽  
Caitlin J. Murphy ◽  
Meihua Sui ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Cancer Drug ◽  
High Drug ◽  
Cancer Drug Delivery ◽  
High Drug Loading

A novel high drug loading mussel-inspired polydopamine hybrid nanoparticle as a pH-sensitive vehicle for drug delivery

2017 ◽  
Vol 533 (1) ◽  
pp. 73-83 ◽  
Author(s):  
Jie Hou ◽  
Chunlei Guo ◽  
Yuzhi Shi ◽  
Ergang Liu ◽  
Weibing Dong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Ph Sensitive ◽  
High Drug ◽  
Hybrid Nanoparticle ◽  
High Drug Loading
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