Thermo- and pH-responsive nano-in-micro particles for combinatorial drug delivery to cancer cells

2017 ◽  
Vol 104 ◽  
pp. 42-51 ◽  
Author(s):  
André F. Moreira ◽  
Diana R. Dias ◽  
Elisabete C. Costa ◽  
Ilídio J. Correia
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Ph Responsive ◽  
Micro Particles

scholarly journals pH and redox dual-sensitive drug delivery system constructed based on fluorescent carbon dots

RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2656-2663
Author(s):  
Boye Zhang ◽  
Qianqian Duan ◽  
Yi Li ◽  
Jianming Wang ◽  
Wendong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Ph Responsive ◽  
Charge Reversal ◽  
Fluorescent Carbon Dots

The system is pH-responsive and redox-controlled release. And the charge reversal and size transitions of the system can enhance the targeted ability. Moreover, the system can recognize the cancer cells by the fluorescence imaging.

scholarly journals Self-assembled pH-responsive supramolecular hydrogel for hydrophobic drug delivery

RSC Advances ◽  
2018 ◽  
Vol 8 (55) ◽  
pp. 31581-31587 ◽  
Author(s):  
Lin Wang ◽  
Xuefeng Shi ◽  
Jian Zhang ◽  
Yuejun Zhu ◽  
Jinben Wang
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hydrophobic Drug ◽  
Ph Responsive ◽  
Supramolecular Hydrogel ◽  
Self Assembled

Supramolecular hydrogel, AGC16/NTS, was used to encapsulate hydrophobic drug curcumin (Cur), constructing a pH-responsive drug delivery system; the uptake of released Cur by cancer cells also occurred.

pH-responsive hydrogel cubes for release of doxorubicin in cancer cells

2014 ◽  
Vol 2 (17) ◽  
pp. 2494-2507 ◽  
Author(s):  
Veronika Kozlovskaya ◽  
Jun Chen ◽  
Chrysanty Tedjo ◽  
Xing Liang ◽  
Javier Campos-Gomez ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Methacrylic Acid ◽  
Ph Responsive

Doxorubicin (DOX)-loaded poly(methacrylic acid) hydrogel cubes release the drug at pH <5. These hydrogels are developed for shape-directed cellular uptake for drug delivery.

scholarly journals Facile synthesis of Prussian blue nanoparticles as pH-responsive drug carriers for combined photothermal-chemo treatment of cancer

RSC Advances ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 248-255 ◽  
Author(s):  
Huajian Chen ◽  
Yan Ma ◽  
Xianwen Wang ◽  
Xiaoyi Wu ◽  
Zhengbao Zha
Keyword(s):  
Drug Delivery ◽  
Prussian Blue ◽  
Cancer Cells ◽  
Drug Carriers ◽  
High Efficacy ◽  
Ph Responsive ◽  
Facile Synthesis ◽  
Drug Delivery Vehicles ◽  
Prussian Blue Nanoparticles ◽  
Delivery Vehicles

Multifunctional PEGylated PB-DOX NPs with a lipid-PEG shell were developed as a gram-scale manner and used as novel pH-responsive drug delivery vehicles for combined photothermal-chemo treatment of cancer cells with high efficacy.

Doxorubicin-loaded pH-responsive chitin nanogels for drug delivery to cancer cells

2012 ◽  
Vol 87 (3) ◽  
pp. 2352-2356 ◽  
Author(s):  
R. Jayakumar ◽  
Amrita Nair ◽  
N. Sanoj Rejinold ◽  
S. Maya ◽  
S.V. Nair
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Ph Responsive

scholarly journals Stimuli-Responsive, Plasmonic Nanogel for Dual Delivery of Curcumin and Photothermal Therapy for Cancer Treatment

2021 ◽  
Vol 8 ◽  
Author(s):  
Fadak Howaili ◽  
Ezgi Özliseli ◽  
Berrin Küçüktürkmen ◽  
Seyyede Mahboubeh Razavi ◽  
Majid Sadeghizadeh ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Drug Carrier ◽  
Drug Loading ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Cytotoxicity Studies

Nanogels (Ng) are crosslinked polymer-based hydrogel nanoparticles considered to be next-generation drug delivery systems due to their superior properties, including high drug loading capacity, low toxicity, and stimuli responsiveness. In this study, dually thermo-pH-responsive plasmonic nanogel (AuNP@Ng) was synthesized by grafting poly (N-isopropyl acrylamide) (PNIPAM) to chitosan (CS) in the presence of a chemical crosslinker to serve as a drug carrier system. The nanogel was further incorporated with gold nanoparticles (AuNP) to provide simultaneous drug delivery and photothermal therapy (PTT). Curcumin's (Cur) low water solubility and low bioavailability are the biggest obstacles to effective use of curcumin for anticancer therapy, and these obstacles can be overcome by utilizing an efficient delivery system. Therefore, curcumin was chosen as a model drug to be loaded into the nanogel for enhancing the anticancer efficiency, and further, its therapeutic efficiency was enhanced by PTT of the formulated AuNP@Ng. Thorough characterization of Ng based on CS and PNIPAM was conducted to confirm successful synthesis. Furthermore, photothermal properties and swelling ratio of fabricated nanoparticles were evaluated. Morphology and size measurements of nanogel were determined by transmission electron microscopy (TEM), scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). Nanogel was found to have a hydrodynamic size of ~167 nm and exhibited sustained release of curcumin up to 72 h with dual thermo-pH responsive drug release behavior, as examined under different temperature and pH conditions. Cytocompatibility of plasmonic nanogel was evaluated on MDA-MB-231 human breast cancer and non-tumorigenic MCF 10A cell lines, and the findings indicated the nanogel formulation to be cytocompatible. Nanoparticle uptake studies showed high internalization of nanoparticles in cancer cells when compared with non-tumorigenic cells and confocal microscopy further demonstrated that AuNP@Ng were internalized into the MDA-MB-231 cancer cells via endosomal route. In vitro cytotoxicity studies revealed dose-dependent and time-dependent drug delivery of curcumin loaded AuNP@Ng/Cur. Furthermore, the developed nanoparticles showed an improved chemotherapy efficacy when irradiated with near-infrared (NIR) laser (808 nm) in vitro. This work revealed that synthesized plasmonic nanogel loaded with curcumin (AuNP@Ng/Cur) can act as stimuli-responsive nanocarriers, having potential for dual therapy i.e., delivery of hydrophobic drug and photothermal therapy.

Daunorubicin -TiO2 Nanocomposites As ‘smart' pH-Responsive Drug Delivery System,

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 3479-3479 ◽  
Author(s):  
Hai-jun Zhang ◽  
Bao-An Chen
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Human Leukemia ◽  
Dependent Manner ◽  
Ph Responsive ◽  
Tio2 Nps ◽  
Anti Tumor Activity

Abstract Abstract 3479 Daunorubicin (DNR) with a broad spectrum of anti-tumor activity is limited due to the serious side-effects in the clinical application. The aim of this study was to explore the novel pH-responsive drug delivery system (DDS) based on titanium dioxide (TiO2) nanoparticles (Nps) for its potential roles to enable more intelligently controlled release, enhance chemotherapeutic efficiency, and reduce the side-effects of DNR. DNR was loaded onto the TiO2 Nps by forming (six-membered chelate) complexes with transition metal Ti to contract DNR-TiO2 nanocomposites as DDS. The encapsulation efficiency and loading efficiency of DNR loaded TiO2 Nps were assessed and calculated as 65.46±6.82% and 20.63±3.55%, respectively.The DNR was released from the DDS much more rapidly at pH 5.0 and 6.0 than at pH 7.4. The release behavior is a desirable characteristic for tumor-targeted drug delivery. Most DNR will remain in the carrier for a considerable time period at normal physiological conditions (pH 7.4), indicating the potential for the prolonged DNR retention time in the blood circulation and thereby greatly reducing the side effects to the normal tissues. On the other hand, once the DNR loaded TiO2 Nps are taken up by tumor cells via endocytotic process, a faster release may occur at lower local pH, i.e, inside the endosome and lysosome of cancer cells ((pH 4.5∼6.5), leading to the significant improvement in cancer treatment efficacy. The DNR- TiO2 nanocomposites as DDS induced the remarkable improvement in the anti-tumor activity, which were demonstrated by the flow cytometry, MTT assay and nuclear DAPI staining. Furthermore, the possible signaling pathway was explored by Western blot. For instance, in human leukemia cells (K562 cells), our observations demonstrated that the DDS could obviously increase the intracellular concentration of DNR and enhance its potential anti-tumor efficiency through inducing apoptosis in a caspase-dependent manner, indicating that DNR-TiO2 nanocomposites could act as an efficient DDS importing DNR into target cancer cells. These findings revealed that such ‘smart' DNR delivery strategy represent a promising approach in hematologic malignancy therapy. Disclosures: No relevant conflicts of interest to declare.

Sign in / Sign up

Export Citation Format

Share Document