Influence of barium sulfate X-ray imaging contrast material on properties of floating drug delivery tablets

2016 ◽  
Vol 95 ◽  
pp. 46-53 ◽  
Author(s):  
Péter Diós ◽  
Krisztián Szigeti ◽  
Ferenc Budán ◽  
Márta Pócsik ◽  
Dániel S. Veres ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Barium Sulfate ◽  
Contrast Material ◽  
X Ray ◽  
X Ray Imaging ◽  
Floating Drug Delivery

A Magnetically Guided Self‐Rolled Microrobot for Targeted Drug Delivery, Real‐Time X‐Ray Imaging, and Microrobot Retrieval

2021 ◽  
pp. 2001681
Author(s):  
Kim Tien Nguyen ◽  
Gwangjun Go ◽  
Zhen Jin ◽  
Bobby Aditya Darmawan ◽  
Ami Yoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Real Time ◽  
Targeted Drug Delivery ◽  
X Ray ◽  
X Ray Imaging ◽  
Targeted Drug

scholarly journals Synthesis of Superparamagnetic Iron Oxide Nanoparticle (SPIONs) for Drug Delivery and X-ray Imaging

2020 ◽  
Vol 2 (1) ◽  
pp. 3
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Caspase 3 ◽  
Superparamagnetic Iron Oxide ◽  
Core Shell ◽  
Nuclear Staining ◽  
X Ray ◽  
The Core ◽  
X Ray Imaging ◽  
Hct 116

Precursor iron molecular solution for the synthesis of SPIONs was optimized for the production of superparamagnetic iron oxide nanoparticles (SPIONs). Thus produced SPIONs were subjected for core-shell – SPIONs synthesis for drug delivery, which had the following four major stages (1) synthesis of SPIONs, (2) functionalization of SPIONs, (3) curcumin loading, and (4) biopolymer coating (Chitosan). Every stage of the synthesis was analyzed using various microscopic (TEM, SEM, AFM) and spectroscopic (UV Vis, FTIR, Zeta Analyzer, Raman Spectroscopy, GIXRD, PXRD, XPS, SQUID, VSM) analysis. Through spectroscopic techniques, mainly the elemental nature and the energy states of elements present all through the core-shell production were studied. The core-shells were subjected to drug delivery studies against HCT 116 and HeLa cells. Core-shell SPIONs were showing IC50 at 30μg and 80μg concentration against HeLa and HCT 116 cell lines, respectively. IC50 concentration was subjected for further anticancer studies through nuclear staining, flow cytometry, and expression of caspase 3 at four-time duration: 2 hours, 6 hours, 12 hours, and 24 hours. The core-shell SPIONs were found to induce cancer apoptosis, which was analyzed using quadrant and histogram statistics obtained as per flow-cytometer. Caspase 3 expression was analyzed using a caspase expression assay. Further, they were evaluated by histogram statistics. SPIONs were utilized as a contrasting agent for X-ray imaging, where it was showing the egg visibility. The response of SPIONs to X-ray was studied with and without the applied magnetic field. Later, the SPIONs were subjected to toxicity study against earthworm.

X-ray Imaging for Gastrointestinal Tracking of Microscale Oral Drug Delivery Devices

2021 ◽  
Author(s):  
Rolf Bech Kjeldsen ◽  
Maja Nørgaard Kristensen ◽  
Carsten Gundlach ◽  
Lasse Højlund Eklund Thamdrup ◽  
Anette Müllertz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
X Ray ◽  
X Ray Imaging ◽  
Drug Delivery Devices

Bioabsorbable bone fixation plates for X‐ray imaging diagnosis by a radiopaque layer of barium sulfate and poly(lactic‐ co ‐glycolic acid)

2014 ◽  
Vol 103 (3) ◽  
pp. 596-607 ◽  
Author(s):  
Sung Yoon Choi ◽  
Woojune Hur ◽  
Byeung Kyu Kim ◽  
Catherine Shasteen ◽  
Myung Hun Kim ◽  
...  
Keyword(s):  
Barium Sulfate ◽  
Glycolic Acid ◽  
Imaging Diagnosis ◽  
X Ray ◽  
Bone Fixation ◽  
X Ray Imaging

Defects of Platelet Function Recognized by X-Ray Imaging and Scanning Electron Microscopy

1985 ◽  
Vol 43 ◽  
pp. 610-613
Author(s):  
M.G. Baldini ◽  
S. Morinaga ◽  
D. Minasian ◽  
R. Feder ◽  
D. Sayre ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Cell Biology ◽  
Imaging Technique ◽  
Human Platelets ◽  
X Rays ◽  
X Ray ◽  
X Ray Imaging ◽  
Complex Phenomena ◽  
Scanning Electron

Contact X-ray imaging is presently developing as an important imaging technique in cell biology. Our recent studies on human platelets have demonstrated that the cytoskeleton of these cells contains photondense structures which can preferentially be imaged by soft X-ray imaging. Our present research has dealt with platelet activation, i.e., the complex phenomena which precede platelet appregation and are associated with profound changes in platelet cytoskeleton. Human platelets suspended in plasma were used. Whole cell mounts were fixed and dehydrated, then exposed to a stationary source of soft X-rays as previously described. Developed replicas and respective grids were studied by scanning electron microscopy (SEM).

Designing high-resolution slow scan CCD-based TEM camera systems

1992 ◽  
Vol 50 (2) ◽  
pp. 946-947
Author(s):  
James F. Mancuso ◽  
William B. Maxwell ◽  
Russell E. Camp ◽  
Mark H. Ellisman
Keyword(s):  
Fiber Optics ◽  
Ccd Camera ◽  
High Energy ◽  
Phosphor Layer ◽  
X Ray ◽  
Light Production ◽  
Camera Systems ◽  
X Ray Imaging ◽  
Electron Image ◽  
Scintillating Fiber

The imaging requirements for 1000 line CCD camera systems include resolution, sensitivity, and field of view. In electronic camera systems these characteristics are determined primarily by the performance of the electro-optic interface. This component converts the electron image into a light image which is ultimately received by a camera sensor.Light production in the interface occurs when high energy electrons strike a phosphor or scintillator. Resolution is limited by electron scattering and absorption. For a constant resolution, more energy deposition occurs in denser phosphors (Figure 1). In this respect, high density x-ray phosphors such as Gd2O2S are better than ZnS based cathode ray tube phosphors. Scintillating fiber optics can be used instead of a discrete phosphor layer. The resolution of scintillating fiber optics that are used in x-ray imaging exceed 20 1p/mm and can be made very large. An example of a digital TEM image using a scintillating fiber optic plate is shown in Figure 2.

Ionic homeostasis and subcellular element compartmentation

1990 ◽  
Vol 48 (2) ◽  
pp. 150-151
Author(s):  
Ann LeFurgey ◽  
Peter Ingram ◽  
J.J. Blum ◽  
M.C. Carney ◽  
L.A. Hawkey ◽  
...  
Keyword(s):  
Leishmania Major ◽  
Ionic Homeostasis ◽  
X Ray ◽  
Functional Studies ◽  
Cell Compartments ◽  
X Ray Imaging ◽  
Resolution Electron ◽  
Multiple Cell ◽  
Role Of Zn

Subcellular compartments commonly identified and analyzed by high resolution electron probe x-ray microanalysis (EPXMA) include mitochondria, cytoplasm and endoplasmic or sarcoplasmic reticulum. These organelles and cell regions are of primary importance in regulation of cell ionic homeostasis. Correlative structural-functional studies, based on the static probe method of EPXMA combined with biochemical and electrophysiological techniques, have focused on the role of these organelles, for example, in maintaining cell calcium homeostasis or in control of excitation-contraction coupling. New methods of real time quantitative x-ray imaging permit simultaneous examination of multiple cell compartments, especially those areas for which both membrane transport properties and element content are less well defined, e.g. nuclei including euchromatin and heterochromatin, lysosomes, mucous granules, storage vacuoles, microvilli. Investigations currently in progress have examined the role of Zn-containing polyphosphate vacuoles in the metabolism of Leishmania major, the distribution of Na, K, S and other elements during anoxia in kidney cell nuclel and lysosomes; the content and distribution of S and Ca in mucous granules of cystic fibrosis (CF) nasal epithelia; the uptake of cationic probes by mltochondria in cultured heart ceils; and the junctional sarcoplasmic retlculum (JSR) in frog skeletal muscle.

Dynamic X-ray imaging of the penetration of boron carbide

2000 ◽  
Vol 10 (PR9) ◽  
pp. Pr9-583-Pr9-588 ◽  
Author(s):  
W. A. Gooch ◽  
M. S. Burkins ◽  
G. Hauver ◽  
P. Netherwood ◽  
R. Benck
Keyword(s):  
Boron Carbide ◽  
X Ray ◽  
X Ray Imaging
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