Study on in situ and in vivo absorption kinetics of phenytoin by modulating P-glycoprotein with verapamil in rats

2011 ◽  
Vol 44 (1-2) ◽  
pp. 27-31 ◽  
Author(s):  
Prasad Neerati ◽  
Dinesh Ganji ◽  
Sathish Kumar Bedada
Keyword(s):  
Absorption Kinetics ◽  
P Glycoprotein ◽  
In Vivo Absorption ◽  
Kinetics Of

Prediction of Digestibility and Intake of Sheep Fed Leguminosae or GRAMINAE Hays: Comparison Between the in Vitro Digestibility, Kinetics of Gas Production or Dry Matter Degradation

1994 ◽  
Vol 1994 ◽  
pp. 103-103
Author(s):  
M.T. Dentinho ◽  
K. Khazaal ◽  
J.M. Ribeiro ◽  
E.R. Ørskov
Keyword(s):  
Dry Matter ◽  
Lolium Multiflorum ◽  
Daily Intake ◽  
Gas Production ◽  
Italian Ryegrass ◽  
In Vitro Digestibility ◽  
Kinetics Of

By using separated values of kinetics of in situ dry matter (DM) degradation or in vitro gas production (Menke and Steingass, 1988) of leguminosae hays, Khazaal et al, (1993) reported high correlation with intake (r= 0.88; r= 0.79) and in vivo DM digestibility (DMD) (r= 0.94; r= 0.88). The aim of the present study was to extend the range of samples used and compare the ability of the 2 stages in vitro digestibility (Tilley and Terry, 1963), the in situ DM degradation or the gas production techniques to predict daily intake (g DM/ kgW0.75) and in vivo DM digestibility (DMD) of 19 leguminous and graminaceous hays fed to sheep.Three harvesting stages (early bloom EB, mid bloom MB or in seed IS) made from lucerne (Medicago sativa), sweet clover (Melilotus segetalis), Persian clover (Trifolium resupinatum), Rye (Secale cereale), Triticale (Triticale hexaploid), oat (Avena stativa) and a pre-bloom (PB) Italian ryegrass (Lolium multiflorum ). Each hay was fed ad libitum to 4 Merino male sheep and their intake and in vivo DMD recorded. Gas production (ml/ 200 mg DM) or in situ DM degradation (g/ 100 g DM) were determined as described by Khazaal et al, (1993) after 6, 12, 24, 48, 72 or 96 h incubation. Measured gas production or DM degradation values were fitted to the equation p=a+b(l-e-ct)(McDonald, 1981) where p is gas production or DM degradation at time t and a, b and c are constants. For nylon bag the washing loss (soluble fraction) was defined as A, the insoluble but fermentable matter was defined as B=(a+b)-A, and c is the rate of fermentation or degradation (Ørskov and Ryle, 1990).

scholarly journals An investigation into the influence of drug lipophilicity on the in vivo absorption profiles from subcutaneous microspheres and in situ forming depots

2007 ◽  
Vol 122 (1) ◽  
pp. 79-85 ◽  
Author(s):  
Claire M Deadman ◽  
Ian W Kellaway ◽  
Mohammed Yasin ◽  
Paul A Dickinson ◽  
Sudaxshina Murdan
Keyword(s):  
In Situ Forming ◽  
In Vivo Absorption

Absorption kinetics of vitamin E nanoemulsion and green tea microstructures by intestinal in situ single perfusion technique in rats

2018 ◽  
Vol 106 ◽  
pp. 149-155 ◽  
Author(s):  
Rijuta Ganesh Saratale ◽  
Hee-Seok Lee ◽  
Yong Eui Koo ◽  
Ganesh Dattatraya Saratale ◽  
Young Jun Kim ◽  
...  
Keyword(s):  
Vitamin E ◽  
Green Tea ◽  
Absorption Kinetics ◽  
Perfusion Technique ◽  
Kinetics Of

scholarly journals In vitro and in situ models for the prediction of in vivo absorption behavior of sulfonamides following dissolution.

1983 ◽  
Vol 31 (9) ◽  
pp. 3284-3291 ◽  
Author(s):  
KANETO UEKAMA ◽  
YUJI UEMURA ◽  
FUMITOSHI HIRAYAMA ◽  
MASAKI OTAGIRI
Keyword(s):  
In Vivo Absorption

Effect of iron source on iron absorption by in situ ligated intestinal loops of broilers

2017 ◽  
Vol 57 (2) ◽  
pp. 308 ◽  
Author(s):  
Xiaofei Li ◽  
Lingyan Zhang ◽  
Liyang Zhang ◽  
Lin Lu ◽  
Xugang Luo
Keyword(s):  
Amino Acids ◽  
Absorption Rate ◽  
Iron Absorption ◽  
Protein Complexes ◽  
Absorption Kinetics ◽  
Main Site ◽  
Dependent Absorption ◽  
Kinetics Of ◽  
Menten Constant

Two experiments were conducted to investigate the effect of iron (Fe) source on Fe absorption by in situ ligated intestinal loops of broilers. In Experiment 1, in situ ligated intestinal loops from Fe-deficient chicks (29 days old) were perfused with solutions containing 0.45 mmol Fe/L from FeSO4 (FeSO4·7H2O), Fe-Gly chelate, Fe-Met chelate, one of three Fe-amino acid or protein complexes with weak, moderate or extremely strong complex strength (Fe-Met W, Fe-Pro M, or Fe-Pro ES), or the mixtures of FeSO4 with either Gly or Met (Fe + Gly or Fe + Met), respectively, up to 30 min. In Experiment 2, in situ ligated duodenal loops from Fe-deficient chicks (29 days old) were perfused with solutions containing 0–3.58 mmol Fe/L from FeSO4, Fe-Met W, Fe-Pro M, or Fe-Pro ES up to 30 min. The absorptions of Fe from both inorganic and organic Fe sources in the ligated duodenum were ~1.35–2.8 times higher (P < 0.05) than that in the ligated jejunum or ileum. The absorption of Fe as Fe-Pro M or Fe-Pro ES was higher (P < 0.05) than that of Fe as inorganic Fe or Fe-Met W at Fe concentration of 3.58 mmol/L. The absorption kinetics of Fe from organic and inorganic Fe sources in the ligated duodenal loops followed a saturable process as determined by regression analysis of concentration-dependent absorption rates. The maximum absorption rate and Michaelis–Menten constant values in the ligated duodenal loops were higher (P < 0.05) for Fe-Pro M and Fe-Pro ES than for FeSO4 and Fe-Met W. The results from this study indicate that the duodenum was the main site of Fe absorption in the intestines of broilers; organic Fe sources with stronger complex strength values showed higher Fe absorptions at a higher concentration of added Fe; and the simple mixture of FeSO4 with amino acids did not increase Fe absorption.

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