Protective effect of 17β-estradiol on ischemic acute kidney injury through the renal sympathetic nervous system

2012 ◽  
Vol 683 (1-3) ◽  
pp. 270-275 ◽  
Author(s):  
Ryosuke Tanaka ◽  
Hidenobu Tsutsui ◽  
Shuhei Kobuchi ◽  
Takahiro Sugiura ◽  
Masayo Yamagata ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
Protective Effect ◽  
Kidney Injury ◽  
17Β Estradiol ◽  
Ischemic Acute Kidney Injury ◽  
Sympathetic Nervous ◽  
Renal Sympathetic

Sex differences in ischemia/reperfusion-induced acute kidney injury are dependent on the renal sympathetic nervous system

2013 ◽  
Vol 714 (1-3) ◽  
pp. 397-404 ◽  
Author(s):  
Ryosuke Tanaka ◽  
Hidenobu Tsutsui ◽  
Mamoru Ohkita ◽  
Masanori Takaoka ◽  
Tokihito Yukimura ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Nervous System ◽  
Sex Differences ◽  
Sympathetic Nervous System ◽  
Ischemia Reperfusion ◽  
Kidney Injury ◽  
Sympathetic Nervous ◽  
Renal Sympathetic

The 2009 Carl Ludwig Lecture: pathophysiology of the human sympathetic nervous system in cardiovascular diseases: the transition from mechanisms to medical management

2010 ◽  
Vol 108 (2) ◽  
pp. 227-237 ◽  
Author(s):  
Murray Esler
Keyword(s):  
Heart Failure ◽  
Nervous System ◽  
Heart Disease ◽  
Essential Hypertension ◽  
Sympathetic Nervous System ◽  
Clinical Translation ◽  
Organ Specific ◽  
Circulatory Control ◽  
Sympathetic Nervous ◽  
Renal Sympathetic

Sympathetic nervous system responses typically are regionally differentiated, with activation in one outflow sometimes accompanying no change or sympathetic inhibition in another. Regional sympathetic activity is best studied in humans by recording from postganglionic sympathetic efferents (multiunit or single fiber recording) and by isotope dilution-derived measurement of organ-specific norepinephrine release to plasma (regional “norepinephrine spillover”). Evidence assembled in this review indicates that sympathetic nervous system abnormalities are crucial in the development of cardiovascular disorders, notably heart failure, essential hypertension, disorders of postural circulatory control causing syncope, and “psychogenic heart disease,” heart disease attributable to mental stress and psychiatric illness. These abnormalities involve persistent, adverse activation of sympathetic outflows to the heart and kidneys in heart failure and hypertension, episodic or ongoing cardiac sympathetic activation in psychogenic heart disease, and defective sympathetic circulatory reflexes in disorders of postural circulatory control. An important goal for clinical scientists is translation of knowledge of pathophysiology, such as this, into better treatment for patients. The achievement of this “mechanisms-to-management” transition is at differing stages of development with the different conditions. Clinical translation is mature in cardiac failure, knowledge of cardiac neural pathophysiology having led to introduction of β-adrenergic blockers, an effective therapy. With essential hypertension, perhaps we are on the cusp of effective translation, with recent successful testing of selective catheter-based renal sympathetic nerve ablation in patients with resistant hypertension, an intervention firmly based on demonstration of activation of the renal sympathetic outflow. With psychogenic heart disease and postural syncope syndromes, knowledge of the neural pathophysiology is emerging, but clinical translation remains for the future.

Arterial pressure lability and renal sympathetic nerve activity are dissociated in SAD rats

1992 ◽  
Vol 263 (3) ◽  
pp. R639-R646 ◽  
Author(s):  
C. Barres ◽  
S. J. Lewis ◽  
H. J. Jacob ◽  
M. J. Brody
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Arterial Pressure ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
High Variability ◽  
Nerve Activity ◽  
Renal Sympathetic Nerve Activity ◽  
Sympathetic Nervous ◽  
Renal Sympathetic

The purpose of this study was to determine whether the sympathetic nervous system drives the high variability of arterial pressure (AP) observed after sinoaortic denervation (SAD) in rats. One or fourteen days after SAD, rats were instrumented chronically to record mean AP (MAP), heart rate (HR), and renal sympathetic nerve activity (RSNA) in the conscious unrestrained state. Acute SAD increased MAP, HR, RSNA, and variability of MAP and decreased variability of both HR and RSNA. In rats with chronic SAD, variability of MAP remained high, whereas MAP, HR, RSNA, and variability of HR and RSNA returned to normal levels. Correlation analysis showed that, in sham-operated rats, AP and RSNA were negatively correlated in 90% of cases. In contrast, rats with both acute and chronic SAD exhibited only 30% negative and 25% positive correlations. These results indicate that 1) low AP variability in intact rats results from baroreflex-mediated inversely related fluctuations in RSNA and HR and 2) high variability of AP after acute and chronic SAD is correlated infrequently with RSNA. Because lability is reduced by interventions that block the sympathetic nervous system, we conclude that lability of AP associated with SAD appears to be mediated largely by a permissive role of sympathetic activity.

The protective effect of the sympathetic nervous system against acoustic trauma

1999 ◽  
Vol 26 (4) ◽  
pp. 375-382 ◽  
Author(s):  
Tetsuro Wada ◽  
Kazuhiko Takahashi ◽  
Zenya Ito ◽  
Akira Hara ◽  
Hideto Takahashi ◽  
...  
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Protective Effect ◽  
Acoustic Trauma ◽  
Sympathetic Nervous

scholarly journals The Protective Effect of a Newly Developed Molecular Chaperone–Inducer Against Mouse Ischemic Acute Kidney Injury

2009 ◽  
Vol 109 (2) ◽  
pp. 311-314 ◽  
Author(s):  
Worapat Prachasilchai ◽  
Hiroko Sonoda ◽  
Naoko Yokota-Ikeda ◽  
Katsuaki Ito ◽  
Takashi Kudo ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Protective Effect ◽  
Molecular Chaperone ◽  
Kidney Injury ◽  
Ischemic Acute Kidney Injury
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