scholarly journals C(5) modified uracil derivatives showing antiproliferative and erythroid differentiation inducing activities on human chronic myelogenous leukemia K562 cells

2011 ◽  
Vol 672 (1-3) ◽  
pp. 30-37 ◽  
Author(s):  
Eleonora Brognara ◽  
Ilaria Lampronti ◽  
Giulia Breveglieri ◽  
Alessandro Accetta ◽  
Roberto Corradini ◽  
...  
Keyword(s):  
Chronic Myelogenous Leukemia ◽  
K562 Cells ◽  
Erythroid Differentiation ◽  
Myelogenous Leukemia ◽  
Uracil Derivatives ◽  
Human Chronic Myelogenous Leukemia

Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cells

2003 ◽  
Vol 94 (6) ◽  
pp. 557-563 ◽  
Author(s):  
Motoi Mukai ◽  
Xiao-Fang Che ◽  
Tatsuhiko Furukawa ◽  
Tomoyuki Sumizawa ◽  
Shunji Aoki ◽  
...  
Keyword(s):  
Chronic Myelogenous Leukemia ◽  
K562 Cells ◽  
Myelogenous Leukemia ◽  
Human Chronic Myelogenous Leukemia

Armillaridin induces autophagy-associated cell death in human chronic myelogenous leukemia K562 cells

Tumor Biology ◽  
2016 ◽  
Vol 37 (10) ◽  
pp. 14291-14300 ◽  
Author(s):  
Wen-Han Chang ◽  
Huey-Lan Huang ◽  
Wei-Pang Huang ◽  
Chien-Chih Chen ◽  
Yu-Jen Chen
Keyword(s):  
Cell Death ◽  
Chronic Myelogenous Leukemia ◽  
K562 Cells ◽  
Myelogenous Leukemia ◽  
Human Chronic Myelogenous Leukemia

scholarly journals Wasabi Compound 6-(Methylsulfinyl) Hexyl Isothiocyanate Induces Cell Death with Coexisting Mitotic Arrest and Autophagy in Human Chronic Myelogenous Leukemia K562 Cells

Biomolecules ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 774 ◽  
Author(s):  
Kun-Ming Wu ◽  
Hui-Fen Liao ◽  
Chih-Wen Chi ◽  
Yu Ru Kou ◽  
Yu-Jen Chen
Keyword(s):  
Cell Death ◽  
Chronic Myelogenous Leukemia ◽  
K562 Cells ◽  
Cyclin B1 ◽  
Mitotic Arrest ◽  
Myelogenous Leukemia ◽  
Cytoplasmic Vacuole ◽  
Acridine Orange Staining ◽  
Human Chronic Myelogenous Leukemia ◽  
M Phase

A natural compound from Wasabia japonica, 6-(methylsulfinyl) hexyl isothiocyanate (6-MITC) was investigated for its anti-leukemia activity and mechanism of action. It was found that 6-MITC inhibited the viability of human chronic myelogenous leukemia K562 cells along with extensive mitotic arrest, spindle multipolarity, and cytoplasmic vacuole accumulation. The evidence of autophagy included the validation of autophagosomes with double-layered membranes under transmission electron microscopy, LC3I/II conversion, and the induction of G2/M phase arrest observed with acridine orange staining of treated cells, as well as the elevation of phosphorylated-histone H3 expression at the M phase. With regard to the expression of proteins related to mitosis, the down regulation of p-CHK1, p-CHK2, p-cdc25c, and p-cdc2, as well as the upregulation of cyclin B1, p-cdc20, cdc23, BubR1, Mad2, and p-plk-1 was observed. The knockdown of cdc20 was unable to block the effect of 6-MITC. The differentiation of k562 cells into monocytes, granulocytes, and megakaryocytes was not affected by 6-MITC. The 6-MITC-induced unique mode of cell death through the concurrent induction of mitosis and autophagy may have therapeutic potential. Further studies are required to elucidate the pathways associated with the counteracting occurrence of mitosis and autophagy.

scholarly journals Caveolin-1 contributes to realgar nanoparticle therapy in human chronic myelogenous leukemia K562 cells

2016 ◽  
Vol Volume 11 ◽  
pp. 5823-5835 ◽  
Author(s):  
Dan Shi ◽  
Yan Liu ◽  
Ronggang Xi ◽  
Wei Zou ◽  
Lijun Wu ◽  
...  
Keyword(s):  
Chronic Myelogenous Leukemia ◽  
K562 Cells ◽  
Myelogenous Leukemia ◽  
Caveolin 1 ◽  
Human Chronic Myelogenous Leukemia

scholarly journals Growth inhibition by STI571 in combination with radiation in human chronic myelogenous leukemia K562 cells

2008 ◽  
Vol 7 (2) ◽  
pp. 398-406 ◽  
Author(s):  
Florence Huguet ◽  
Nicole Giocanti ◽  
Christophe Hennequin ◽  
Martine Croisy ◽  
Emmanuel Touboul ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
Chronic Myelogenous Leukemia ◽  
K562 Cells ◽  
Myelogenous Leukemia ◽  
Human Chronic Myelogenous Leukemia
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