The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes

2007 ◽  
Vol 567 (3) ◽  
pp. 206-210 ◽  
Author(s):  
Kristoffer Sahlholm ◽  
Johanna Nilsson ◽  
Daniel Marcellino ◽  
Kjell Fuxe ◽  
Peter Århem
Keyword(s):  
Xenopus Oocytes ◽  
Girk Channels ◽  
Histamine H3 Receptor ◽  
H3 Receptor ◽  
Human Histamine ◽  
Histamine H3

The naturally occurring mutation Y197C does not affect the expression or signaling of the human histamine H3 receptor

2017 ◽  
Vol 641 ◽  
pp. 77-80
Author(s):  
Cecilia Flores-Clemente ◽  
Juan Escamilla-Sánchez ◽  
Juan-Manuel Arias ◽  
José-Antonio Arias-Montaño
Keyword(s):  
Histamine H3 Receptor ◽  
Naturally Occurring ◽  
H3 Receptor ◽  
Human Histamine ◽  
Histamine H3

Differential expression and signaling of the human histamine H3 receptor isoforms of 445 and 365 amino acids expressed in human neuroblastoma SH-SY5Y cells

2018 ◽  
Vol 38 (2) ◽  
pp. 141-150 ◽  
Author(s):  
Gustavo Nieto-Alamilla ◽  
Juan Escamilla-Sánchez ◽  
María-Cristina López-Méndez ◽  
Anayansi Molina-Hernández ◽  
Agustín Guerrero-Hernández ◽  
...  
Keyword(s):  
Amino Acids ◽  
Differential Expression ◽  
Human Neuroblastoma ◽  
Histamine H3 Receptor ◽  
H3 Receptor ◽  
Receptor Isoforms ◽  
Human Histamine ◽  
Histamine H3

Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist

2004 ◽  
Vol 68 (5) ◽  
pp. 933-945 ◽  
Author(s):  
Timothy A Esbenshade ◽  
Gerard B Fox ◽  
Kathleen M Krueger ◽  
John L Baranowski ◽  
Thomas R Miller ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Histamine H3 Receptor ◽  
H3 Receptor ◽  
Human Histamine ◽  
Histamine H3

Genomic organization and characterization of splice variants of the human histamine H3 receptor

2001 ◽  
Vol 355 (2) ◽  
pp. 279-288 ◽  
Author(s):  
Francis COGÉ ◽  
Sophie-Pénélope GUÉNIN ◽  
Valérie AUDINOT ◽  
Anne RENOUARD-TRY ◽  
Philippe BEAUVERGER ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Cho Cells ◽  
Genomic Organization ◽  
Splice Variants ◽  
Relative Distribution ◽  
Binding Studies ◽  
Histamine H3 Receptor ◽  
H3 Receptor ◽  
Human Histamine ◽  
Histamine H3

In the present paper we report the genomic organization of the human histamine H3-receptor gene, which consists of four exons spanning 5.5kb on chromosome 20. Using PCR, six alternative splice variants of the H3 receptor were cloned from human thalamus. These variants were found to be coexpressed in human brain, but their relative distribution varied in a region-specific manner. These isoforms displayed either a deletion in the putative second transmembrane domain (TM), H3(∆TM2, 431aa) or a variable deletion in the third intracellular loop (i3), H3(∆i3, 415aa), H3(∆i3, 365aa), H3(∆i3, 329aa) and H3(∆TM5+∆i3, 326aa). In order to determine the biological role of the H3 receptor variants compared with the ‘original’ H3(445aa) receptor, three isoforms, namely H3(445aa), H3(∆TM2, 431aa) and H3(∆i3, 365aa), were expressed in CHO cells and their pharmacological properties were investigated. Binding studies showed that H3(∆TM2,431aa) transiently expressed in CHO cells was unable to bind [125I]iodoproxyfan, whereas both the H3(445aa) and H3(∆i3, 365aa) receptors displayed a high affinity for [125I]iodoproxyfan [Kd = 28±5pM (n = 4) and 8±1pM (n = 5) respectively]. In addition, H3(∆i3, 365aa) possessed the same pharmacological profile as the H3(445aa) receptor. However, in CHO cells expressing H3(∆i3, 365aa), H3 agonists did not inhibit forskolin-induced cAMP production, stimulate [35S]guanosine 5′-[γ-thio]triphosphate ([35S]GTP[S]) binding or stimulate intracellular Ca2+ mobilization. Therefore the 80-amino-acid sequence located at the C-terminal portion of i3 plays an essential role in H3 agonist-mediated signal transduction. The existence of multiple H3 isoforms with different signal transduction capabilities suggests that H3-mediated biological functions might be tightly regulated through alternative splicing mechanisms.

Diamine-based human histamine H3 receptor antagonists: (4-Aminobutyn-1-yl)benzylamines

2009 ◽  
Vol 44 (10) ◽  
pp. 4098-4106 ◽  
Author(s):  
Curt A. Dvorak ◽  
Richard Apodaca ◽  
Wei Xiao ◽  
Jill A. Jablonowski ◽  
Pascal Bonaventure ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Histamine H3 Receptor ◽  
H3 Receptor ◽  
Human Histamine ◽  
Histamine H3

Synthesis and structure–activity relationships of N-aryl-piperidine derivatives as potent (partial) agonists for human histamine H3 receptor

2010 ◽  
Vol 18 (14) ◽  
pp. 5441-5448 ◽  
Author(s):  
Makoto Ishikawa ◽  
Takeshi Furuuchi ◽  
Miki Yamauchi ◽  
Fumikazu Yokoyama ◽  
Nobukazu Kakui ◽  
...  
Keyword(s):  
Histamine H3 Receptor ◽  
Structure Activity Relationships ◽  
Partial Agonists ◽  
Structure Activity ◽  
H3 Receptor ◽  
Human Histamine ◽  
Histamine H3

Chromosomal mapping and organization of the human histamine H3 receptor gene

Neuroreport ◽  
2001 ◽  
Vol 12 (2) ◽  
pp. 321-324 ◽  
Author(s):  
Joël Tardivel-Lacombe ◽  
Séverine Morisset ◽  
Florence Gbahou ◽  
Jean-Charles Schwartz ◽  
Jean-Michel Arrang
Keyword(s):  
Receptor Gene ◽  
Chromosomal Mapping ◽  
Histamine H3 Receptor ◽  
H3 Receptor ◽  
Human Histamine ◽  
Histamine H3
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