Protective effects of minocycline on 3,4-methylenedioxymethamphetamine-induced neurotoxicity in serotonergic and dopaminergic neurons of mouse brain

2006 ◽  
Vol 544 (1-3) ◽  
pp. 1-9 ◽  
Author(s):  
Lin Zhang ◽  
Yukihiko Shirayama ◽  
Eiji Shimizu ◽  
Masaomi Iyo ◽  
Kenji Hashimoto
Keyword(s):  
Mouse Brain ◽  
Dopaminergic Neurons ◽  
Protective Effects

Protective effects of berberine against MPTP-induced dopaminergic neuron injury through promoting autophagy in mice

2021 ◽  
Author(s):  
Han Deng ◽  
ZeGang Ma
Keyword(s):  
Dopaminergic Neurons ◽  
Dopaminergic Neuron ◽  
Protective Effects ◽  
Neuron Injury

Berberine protects dopaminergic neurons in SN of MPTP-induced mice via the enhancement of AMPK-mediated autophagy.

scholarly journals Strain- and age-dependent features of the nigro-striatal circuit in three common laboratory mouse strains, C57BL/6J, A/J, and DBA/2J - Implications for Parkinson’s disease modeling

2020 ◽  
Author(s):  
Mélanie H. Thomas ◽  
Mona Karout ◽  
Beatriz Pardo Rodriguez ◽  
Yujuan Gui ◽  
Christian Jaeger ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Brain ◽  
Dopaminergic Neurons ◽  
Mouse Strains ◽  
List Type ◽  
Background Strain ◽  
Age Related ◽  
Health And Disease ◽  
Over Time

AbstractMouse models have been instrumental in understanding genetic determinants of aging and its crucial role in neurodegenerative diseases. However, few studies have analyzed the evolution of the mouse brain over time at baseline. Furthermore, mouse brain studies are commonly conducted on the C57BL/6 strain, limiting the analysis to a specific genetic background. In Parkinson’s disease, the gradual demise of nigral dopaminergic neurons mainly contributes to the motor symptoms. Interestingly, a decline of the dopaminergic neuron function and integrity is also a characteristic of physiological aging in some species. Age-related nigro-striatal features have never been studied in mice of different genetic backgrounds. In this study, we analyze the morphological features in the striatum of three common mouse strains, C57BL/6J, A/J, and DBA/2J at 3-, 9- and 15 months of age. By measuring dopaminergic markers, we uncover age-related changes that differ between strains and evolve dynamically over time. Overall, our results highlight the importance of considering background strain and age when studying the murine nigro-striatal circuit in health and disease.HighlightsStudy of the integrity of the nigro-striatal circuit in C57BL/6J, A/J, and DBA/2J at different agesAge related evolution of essential features of nigral dopaminergic neurons differ between strainsConsider background strain and age is crutial to study the nigrostriatal circuit in health and disease

scholarly journals Apelin-13 Protects Dopaminergic Neurons against Rotenone—Induced Neurotoxicity through the AMPK/mTOR/ULK-1 Mediated Autophagy Activation

2020 ◽  
Vol 21 (21) ◽  
pp. 8376
Author(s):  
Peng Chen ◽  
Youcui Wang ◽  
Leilei Chen ◽  
Ning Song ◽  
Junxia Xie
Keyword(s):  
Dopaminergic Neurons ◽  
Substantia Nigra Pars Compacta ◽  
Protective Effects ◽  
Gut Peptides ◽  
Neuroprotective Effects ◽  
Compound C ◽  
Apelin Receptor ◽  
Signaling Activation

Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Several brain–gut peptides are able to exert neuroprotective effects on the nigrostriatal dopaminergic system. Apelin-13 is a neuropeptide, conveying potential neuroprotective activities. However, whether, and how, apelin-13 could antagonize rotenone-induced neurotoxicity has not yet been elucidated. In the present study, rotenone-treated SH-SY5Y cells and rats were used to clarify whether apelin-13 has protective effects on dopaminergic neurons, both in vivo and in vitro. The results showed that apelin-13 could protect SH-SY5Y cells from rotenone-induced injury and apoptosis. Apelin-13 was able to activate autophagy, and restore rotenone induced autophagy impairment in SH-SY5Y cells, which could be blocked by the autophagy inhibitor 3-Methyladenine. Apelin-13 activated AMPK/mTOR/ULK-1 signaling, AMPKα inhibitor compound C, as well as apelin receptor blockage via siRNA, which could block apelin-13-induced signaling activation, autophagy activation, and protective effects, in rotenone-treated SH-SY5Y cells. These results indicated that apelin-13 exerted neuroprotective properties against rotenone by stimulating AMPK/mTOR/ULK-1 signaling-mediated autophagy via the apelin receptor. We also observed that intracerebroventricular injection of apelin-13 could alleviate nigrostriatal dopaminergic neuron degeneration in rotenone-treated rats. Our findings provide new insights into the mechanism by which apelin-13 might attenuate neurotoxicity in PD.

Cytosolic labile zinc accumulation in degenerating dopaminergic neurons of mouse brain after MPTP treatment

2009 ◽  
Vol 1286 ◽  
pp. 208-214 ◽  
Author(s):  
Joo-Yong Lee ◽  
Hyo Jin Son ◽  
Ji Hyun Choi ◽  
Eunsil Cho ◽  
Jean Kim ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Dopaminergic Neurons ◽  
Zinc Accumulation ◽  
Mptp Treatment

2.441 Nicotine provides protective effects in dopaminergic neurons via the nicotinic receptors

2007 ◽  
Vol 13 ◽  
pp. S138
Author(s):  
H. Takeuchi ◽  
T. Yanagida ◽  
K. Takata ◽  
Y. Kitamura ◽  
T. Taniguchi ◽  
...  
Keyword(s):  
Dopaminergic Neurons ◽  
Nicotinic Receptors ◽  
Protective Effects

Protective effects of melatonin against 12C6+ beam irradiation-induced oxidative stress and DNA injury in the mouse brain

2012 ◽  
Vol 49 (1) ◽  
pp. 196-203 ◽  
Author(s):  
Z.H. Wu ◽  
H. Zhang ◽  
X.Y. Wang ◽  
R. Yang ◽  
B. Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Brain ◽  
Protective Effects ◽  
Beam Irradiation

Protective effects of fisetin and other berry flavonoids in Parkinson's disease

2017 ◽  
Vol 8 (9) ◽  
pp. 3033-3042 ◽  
Author(s):  
Pamela Maher
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Dopaminergic Neurons ◽  
Degenerative Disease ◽  
Protective Effects

Parkinson's disease (PD) is an age-associated degenerative disease of the midbrain that results from the loss of dopaminergic neurons in the substantia nigra.

Sign in / Sign up

Export Citation Format

Share Document