Comparison of poly(ε-caprolactone) chain lengths of poly(ε-caprolactone)-co-d-α-tocopheryl-poly(ethylene glycol) 1000 succinate nanoparticles for enhancement of quercetin delivery to SKBR3 breast cancer cells

2016 ◽  
Vol 101 ◽  
pp. 15-24 ◽  
Author(s):  
Jiraphong Suksiriworapong ◽  
Kittisak Phoca ◽  
Supakanda Ngamsom ◽  
Kittisak Sripha ◽  
Primchanien Moongkarndi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ethylene Glycol ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Chain Lengths

Selective chemotherapy and imaging of colorectal and breast cancer cells by a modified MUC-1 aptamer conjugated to a poly(ethylene glycol)-dimethacrylate coated Fe3O4–AuNCs nanocomposite

2019 ◽  
Vol 43 (1) ◽  
pp. 238-248 ◽  
Author(s):  
Roya Binaymotlagh ◽  
Farid Hajareh Haghighi ◽  
Fatemeh Aboutalebi ◽  
Seyede Zohreh Mirahmadi-Zare ◽  
Hassan Hadadzadeh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Targeted Therapy ◽  
Ethylene Glycol ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Molecular Medicine ◽  
Glycol Dimethacrylate ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Selective Chemotherapy

The combination of diagnosis and targeted therapy within a single nanoplatform is one of the remarkable advances in molecular medicine.

scholarly journals Cytotoxic Effect of Paclitaxel and Lapatinib Co-Delivered in Polylactide-co-Poly(ethylene glycol) Micelles on HER-2-Negative Breast Cancer Cells

Pharmaceutics ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 169 ◽  
Author(s):  
Alicja Zajdel ◽  
Adam Wilczok ◽  
Katarzyna Jelonek ◽  
Monika Musiał-Kulik ◽  
Aleksander Foryś ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Binary Mixture ◽  
Ethylene Glycol ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cytotoxic Effect ◽  
Poly Ethylene Glycol ◽  
Her 2 ◽  
Poly Ethylene ◽  
Mcf 7

To find better strategies to enhance the cytotoxic effect of paclitaxel (PTX) and lapatinib (LAP) against breast cancer cells, we analyzed the efficacy of a novel delivery system containing polylactide-co-poly(ethylene glycol) (PLA-PEG) filomicelles of over 100 nm in length and spherical micelles of approximately 20 nm in diameter. The 1H NMR measurements confirmed the incorporation of PTX and LAP into micelles. Analysis of the drug release mechanism revealed the diffusion-controlled release of LAP and anomalous transport of PTX. Drug content analysis in lyophilized micelles and micellar solution showed their good storage stability for at least 6 weeks. Blank micelles, LAP-loaded micelles and free LAP did not affect MCF-7 breast cancer cell proliferation, suggesting that the cytotoxicity of PTX-, PTX/LAP-loaded micelles, and the binary mixture of free PTX and LAP was solely caused by PTX. PTX/LAP-loaded micelles showed greater toxicity compared to the binary mixture of PTX and LAP after 48 h and 72 h. Only free PTX alone induced P-gp activity. This study showed the feasibility of using a LAP and PTX combination to overcome MDR in MCF-7 cells, particularly when co-loaded into micelles. We suggest that PTX/LAP micelles can be applicable not only for the therapy of HER-2-positive, but also HER-2-negative breast cancers.

Peptide functionalized poly ethylene glycol-poly caprolactone nanomicelles for specific cabazitaxel delivery to metastatic breast cancer cells

2017 ◽  
Vol 80 ◽  
pp. 301-312 ◽  
Author(s):  
Parvin Mahdaviani ◽  
Saeed Bahadorikhalili ◽  
Mona Navaei-Nigjeh ◽  
Seyed Yaser Vafaei ◽  
Mehdi Esfandyari-Manesh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Ethylene Glycol ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Metastatic Breast ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Poly Caprolactone

Methoxy Poly(ethylene glycol)-Poly(lactide) Nanoparticles Encapsulating Quercetin Act as an Effective Anticancer Agent by Inducing Apoptosis in Breast Cancer

2014 ◽  
Vol 32 (2) ◽  
pp. 723-735 ◽  
Author(s):  
Garima Sharma ◽  
Jongbong Park ◽  
Ashish Ranjan Sharma ◽  
Jun-Sub Jung ◽  
Haesung Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ethylene Glycol ◽  
Anticancer Agent ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Poly(ethylene glycol)–paclitaxel–alendronate self-assembled micelles for the targeted treatment of breast cancer bone metastases

Biomaterials ◽  
2013 ◽  
Vol 34 (15) ◽  
pp. 3795-3806 ◽  
Author(s):  
Keren Miller ◽  
Chiara Clementi ◽  
Dina Polyak ◽  
Anat Eldar-Boock ◽  
Liat Benayoun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ethylene Glycol ◽  
Bone Metastases ◽  
Targeted Treatment ◽  
Poly Ethylene Glycol ◽  
Self Assembled ◽  
Poly Ethylene

scholarly journals Polymer Electrolytes Based on Borane/Poly(ethylene glycol) Methyl Ether for Lithium Batteries

2017 ◽  
Vol 2017 ◽  
pp. 1-6
Author(s):  
Ali Murat Soydan ◽  
Recep Akdeniz
Keyword(s):  
Ethylene Glycol ◽  
Methyl Ether ◽  
Polymer Electrolytes ◽  
Lithium Ion ◽  
Poly Ethylene Glycol ◽  
Scanning Calorimetry ◽  
Molar Ratios ◽  
Poly Ethylene ◽  
Chain Lengths ◽  
Glycol Methyl Ether

This work presents a different approach to preparing polymer electrolytes having borate ester groups for lithium ion batteries. The polymers were synthesized by reaction between poly(ethylene glycol) methyl ether (PEGME) and BH3-THF complex. Molecular weight of PEGMEs was changed with different chain lengths. Then the polymer electrolytes comprising boron were prepared by doping of the matrices with CF3SO3Li at various molar ratios with respect to EO to Li and they are abbreviated as PEGMEX-B-Y. The identification of the PEGME-borate esters was carried out by FTIR and 1H NMR spectroscopy. Thermal properties of these electrolytes were investigated via thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The ionic conductivity of these novel polymer electrolytes was studied by dielectric-impedance spectroscopy. Lithium ion conductivity of these electrolytes was changed by the length of PEGME as well as the doping ratios. They exhibit approximate conductivities of 10−4 S·cm−1 at 30°C and 10−3 S·cm−1 at 100°C.

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