Liquid crystalline phases of monoolein and water for topical delivery of cyclosporin A: Characterization and study of in vitro and in vivo delivery

2006 ◽  
Vol 63 (2) ◽  
pp. 146-155 ◽  
Author(s):  
Luciana B. Lopes ◽  
João L.C. Lopes ◽  
Dionéia C.R. Oliveira ◽  
José A. Thomazini ◽  
M. Tereza J. Garcia ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Liquid Crystalline ◽  
Topical Delivery ◽  
Crystalline Phases ◽  
Liquid Crystalline Phases ◽  
In Vivo Delivery

Invite Article: The Liquid-Crystalline Phases of Double-Stranded Nucleic Acids in Vitro and in Vivo

1988 ◽  
Vol 3 (11) ◽  
pp. 1443-1459 ◽  
Author(s):  
Yu M. Yevdokimov ◽  
S. G. Skuridin ◽  
V. I. Salyanov
Keyword(s):  
Nucleic Acids ◽  
Liquid Crystalline ◽  
Crystalline Phases ◽  
Liquid Crystalline Phases

Use of light microscopy in the qualitative and quantitative study of liquid crystalline order

1992 ◽  
Vol 50 (1) ◽  
pp. 264-265
Author(s):  
Christopher Viney
Keyword(s):  
Light Microscopy ◽  
Liquid Crystalline ◽  
Structural Characteristics ◽  
Molecular Order ◽  
Liquid Crystalline Phases ◽  
Convenient Technique ◽  
Liquid Crystalline Materials ◽  
Transparent Windows

Light microscopy is a convenient technique for characterizing molecular order in fluid liquid crystalline materials. Microstructures can usually be observed under the actual conditions that promote the formation of liquid crystalline phases, whether or not a solvent is required, and at temperatures that can range from the boiling point of nitrogen to 600°C. It is relatively easy to produce specimens that are sufficiently thin and flat, simply by confining a droplet between glass cover slides. Specimens do not need to be conducting, and they do not have to be maintained in a vacuum. Drybox or other controlled environmental conditions can be maintained in a sealed chamber equipped with transparent windows; some heating/ freezing stages can be used for this purpose. It is relatively easy to construct a modified stage so that the generation and relaxation of global molecular order can be observed while specimens are being sheared, simulating flow conditions that exist during processing. Also, light only rarely affects the chemical composition or molecular weight distribution of the sample. Because little or no processing is required after collecting the sample, one can be confident that biologically derived materials will reveal many of their in vivo structural characteristics, even though microscopy is performed in vitro.

Influence of Internal Structure and Composition of Liquid Crystalline Phases on Topical Delivery of Paclitaxel

2011 ◽  
Vol 100 (4) ◽  
pp. 1444-1455 ◽  
Author(s):  
Jaclyn M. Hosmer ◽  
Soo H. Shin ◽  
Adwoa Nornoo ◽  
Haian Zheng ◽  
Luciana B. Lopes
Keyword(s):  
Internal Structure ◽  
Liquid Crystalline ◽  
Topical Delivery ◽  
Crystalline Phases ◽  
Liquid Crystalline Phases

Monoolein liquid crystalline phases for topical delivery of crocetin

2018 ◽  
Vol 171 ◽  
pp. 67-74 ◽  
Author(s):  
Elisabetta Esposito ◽  
Federica Carducci ◽  
Paolo Mariani ◽  
Nicolas Huang ◽  
Fanny Simelière ◽  
...  
Keyword(s):  
Liquid Crystalline ◽  
Topical Delivery ◽  
Crystalline Phases ◽  
Liquid Crystalline Phases

Molecular Order in Silk Secretions

1991 ◽  
Vol 248 ◽  
Author(s):  
Christopher Viney ◽  
Keven Kerkam ◽  
Lisa Gilliland ◽  
David Kaplan ◽  
Stephen Fossey
Keyword(s):  
Liquid Crystalline ◽  
Polarized Light ◽  
Amino Acid Sequences ◽  
Silk Proteins ◽  
Secondary Structure Analysis ◽  
Liquid Crystalline Phases ◽  
Strength And Stiffness ◽  
Supramolecular Aggregates

AbstractTransmitted polarized light microscopy of various natural silk secretions reveals their ability to form nematic liquid crystalline phases. Observations of microstructure, together with a simple secondary structure analysis of known amino acid sequences in silk proteins, suggest that the rodlike structures forming the nematic phase are supramolecular aggregates, rather than individual rigid molecular segments. The optical birefringence of dragline fiber produced by controlled silking depends on the linear haul-off velocity, and can exceed the birefringence of naturally spun fibers; this suggests the possibility of in-vitro spinning of silk to obtain values of strength and stiffness even greater than those achieved in vivo.

Reverse Hexagonal Phase Nanodispersion of Monoolein and Oleic Acid for Topical Delivery of Peptides: in Vitro and in Vivo Skin Penetration of Cyclosporin A

2006 ◽  
Vol 23 (6) ◽  
pp. 1332-1342 ◽  
Author(s):  
Luciana B. Lopes ◽  
Denise A. Ferreira ◽  
Daniel de Paula ◽  
M. Tereza J. Garcia ◽  
José A. Thomazini ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Cyclosporin A ◽  
Hexagonal Phase ◽  
Skin Penetration ◽  
Topical Delivery ◽  
In Vivo Skin Penetration

Solid Lipid Nanoparticles (SLNs) Gels for Topical Delivery of Aceclofenac in vitro and in vivo Evaluation

2013 ◽  
Vol 10 (6) ◽  
pp. 656-666 ◽  
Author(s):  
Sandipan Dasgupta ◽  
Surajit Ghosh ◽  
Subhabrata Ray ◽  
Bhaskar Mazumder
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Topical Delivery ◽  
Lipid Nanoparticles ◽  
In Vivo Evaluation ◽  
Solid Lipid
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