The impact on quality of life for people with brain tumours of entering a research trial involving new anti-cancer agents

2013 ◽  
Vol 17 (4) ◽  
pp. 396-401 ◽  
Author(s):  
Katie Sutton
Keyword(s):  
Quality Of Life ◽  
Brain Tumours ◽  
Anti Cancer ◽  
The Impact

scholarly journals The impact of cancer therapy on the endocrine system in survivors of childhood brain tumours

2004 ◽  
Vol 11 (4) ◽  
pp. 589-602 ◽  
Author(s):  
H K Gleeson ◽  
S M Shalet
Keyword(s):  
Quality Of Life ◽  
Cancer Therapy ◽  
Brain Tumours ◽  
Final Height ◽  
Cranial Irradiation ◽  
Early Puberty ◽  
Gh Therapy ◽  
Childhood Brain Tumours ◽  
The Impact

Survival rates are improving following cancer therapy for childhood brain tumours. There is therefore a growing cohort of survivors at risk of late effects of cancer therapy. Endocrine problems are very common in these patients. The recognition and prompt management of these are essential to prevent further morbidity and impairment of quality of life. Cranial radiation can damage hypothalamic–pituitary function, most frequently affecting GH status; however, higher radiation doses may cause more widespread hypothalamic–pituitary damage. Early puberty secondary to cranial irradiation is now being managed with gonadotrophin-releasing hormone analogues to improve final height. Prompt diagnosis and management of GH deficiency may improve final height outcome; continued GH therapy beyond final height aids the achievement of adult body composition (lean body mass and bone mass) and GH therapy in adulthood improves quality of life. Both cranial irradiation alone and with spinal irradiation can result in radiation damage to the thyroid resulting in hypothyroidism and thyroid nodules, a high proportion of which are malignant. Gonadal damage secondary to spinal irradiation and adjuvant chemotherapy may have long-term consequences including infertility.

scholarly journals The impact of quality-of-life data in relative effectiveness assessments of new anti-cancer drugs in European countries

2017 ◽  
Vol 26 (9) ◽  
pp. 2479-2488 ◽  
Author(s):  
Sarah Kleijnen ◽  
Teresa Leonardo Alves ◽  
Kim Meijboom ◽  
Iga Lipska ◽  
Anthonius De Boer ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Relative Effectiveness ◽  
Cancer Drugs ◽  
National Guidelines ◽  
Anti Cancer ◽  
Related Quality ◽  
Health Related ◽  
Assessment Procedures ◽  
The Impact

Abstract Purpose The aim of this study is to investigate the role of health-related quality-of-life (QoL) data in relative effectiveness assessments (REAs) of new anti-cancer drugs across European jurisdictions, during health technology assessment procedures. Methods Comparative analysis of guidelines and publicly available REAs in six European jurisdictions of anti-cancer drugs approved by EMA between 2011 and 2013. Results Fourteen anti-cancer drugs were included, adding up to 79 REAs. Whilst all guidelines state that QoL is a relevant endpoint to determine the relative effectiveness of new cancer drugs, QoL data were included in only 54% of the 79 reports and their impact on the recommendations was limited. Conclusions Whilst national guidelines recognize the relevance of QoL to determine the relative effectiveness of new anti-cancer drugs, this is not well-reflected in current assessments. Developing and implementing into REAs specific evidence requirements for QoL data would improve the use of this patient-centred outcome in future reimbursement and pricing decisions.

scholarly journals A Two-Arm Randomized Pilot Study to Evaluate the Impact of a Mobile Health App on Quality of Life in Patients on Oral Anti-Cancer Medications (Preprint)

2018 ◽  
Author(s):  
Nils Fischer ◽  
Stephen Agboola ◽  
Ramya Palacholla ◽  
Mursal Atif ◽  
Joseph Kvedar ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Usual Care ◽  
Cancer Patients ◽  
Intervention Group ◽  
Continuous Variable ◽  
Care Quality ◽  
Control Group ◽  
Anti Cancer ◽  
The Impact

BACKGROUND CORA is a personalized smartphone-based self-management app designed to help cancer patients on oral anti-cancer medications manage medication, medication side-effects, and symptoms with the overall goal of improving their quality of life. OBJECTIVE To evaluate the effect of CORA on quality of life in patients on oral anti-cancer medications. METHODS Eighty-four patients were randomized to either an intervention group that received CORA plus usual care or a control group that received usual care. Quality of life was measured using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale administered at enrollment, 6 and 12 weeks. Engagement with the app was assessed by determining the unique days using the app. We evaluated the effect of engagement on FACIT-F both as a continuous variable (days using the app) and as a categorical outcome (low, medium, and high). Group differences for all outcomes over the study period were assessed using repeated measures mixed model analysis. RESULTS Relative to the control group, the intervention group improved FACIT-F by 0.36 (95% CI 0.10-0.61) P=.006 per week over the study period. As a continuous variable, each additional day using the app was significantly associated with an improved FACIT-F score per week in the study [0.0060 (95% CI -0.000034-0.012), P=.05]. Within the intervention group that used the app, those who were most engaged with the app were significantly more likely to improve their quality of life over the study relative to the least engaged group [0.37 per week (95% CI 0.19-1.94), P=.05]. CONCLUSIONS CORA may have significantly improved quality of life (FACIT-F) in cancer patients over 12 weeks. Smartphone applications may positively impact health and behavioral outcomes in cancer patients on oral anti-cancer medications.

scholarly journals A Two-Arm Randomized Pilot Study to Evaluate the Impact of a Mobile Health App on Quality of Life in Patients on Oral Anti-Cancer Medications

Iproceedings ◽  
10.2196/11830 ◽  
2018 ◽  
Vol 4 (2) ◽  
pp. e11830
Author(s):  
Nils Fischer ◽  
Stephen Agboola ◽  
Ramya Palacholla ◽  
Mursal Atif ◽  
Joseph Kvedar ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pilot Study ◽  
Mobile Health ◽  
Anti Cancer ◽  
The Impact

Self-Compassion and Quality of Life in Adults Who Stutter

2020 ◽  
Vol 29 (4) ◽  
pp. 2097-2108
Author(s):  
Robyn L. Croft ◽  
Courtney T. Byrd
Keyword(s):  
Quality Of Life ◽  
Social Connectedness ◽  
The Self ◽  
Future Research ◽  
Self Compassion ◽  
Adults Who Stutter ◽  
And Gender ◽  
Relationship Of ◽  
The Impact

Purpose The purpose of this study was to identify levels of self-compassion in adults who do and do not stutter and to determine whether self-compassion predicts the impact of stuttering on quality of life in adults who stutter. Method Participants included 140 adults who do and do not stutter matched for age and gender. All participants completed the Self-Compassion Scale. Adults who stutter also completed the Overall Assessment of the Speaker's Experience of Stuttering. Data were analyzed for self-compassion differences between and within adults who do and do not stutter and to predict self-compassion on quality of life in adults who stutter. Results Adults who do and do not stutter exhibited no significant differences in total self-compassion, regardless of participant gender. A simple linear regression of the total self-compassion score and total Overall Assessment of the Speaker's Experience of Stuttering score showed a significant, negative linear relationship of self-compassion predicting the impact of stuttering on quality of life. Conclusions Data suggest that higher levels of self-kindness, mindfulness, and social connectedness (i.e., self-compassion) are related to reduced negative reactions to stuttering, an increased participation in daily communication situations, and an improved overall quality of life. Future research should replicate current findings and identify moderators of the self-compassion–quality of life relationship.

Health and Quality of Life in PTSD: What is the Impact of Co-Occurring Depression?

2008 ◽  
Author(s):  
Jennifer S. Fabritius ◽  
Lisa S. Doane ◽  
Aileen M. Echiverri ◽  
Shoshana Y. Kahana ◽  
Joshua D. McDavid ◽  
...  
Keyword(s):  
Quality Of Life ◽  
The Impact
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