A longitudinal study about the body image and psychosocial adjustment of breast cancer patients during the course of the disease

2010 ◽  
Vol 14 (4) ◽  
pp. 263-270 ◽  
Author(s):  
Helena Moreira ◽  
Maria Cristina Canavarro
Keyword(s):  
Breast Cancer ◽  
Body Image ◽  
Longitudinal Study ◽  
Cancer Patients ◽  
Psychosocial Adjustment ◽  
The Body ◽  
Breast Cancer Patients

scholarly journals The Body-image Changes in Breast Cancer Patients versus Self-perception

2009 ◽  
Vol 59 (1) ◽  
pp. 15-24 ◽  
Author(s):  
Eiko Hagiwara ◽  
Fumiyo Fujino ◽  
Tamae Futawatari
Keyword(s):  
Breast Cancer ◽  
Body Image ◽  
Cancer Patients ◽  
The Body ◽  
Breast Cancer Patients ◽  
Self Perception

scholarly journals CBR3 V244M is associated with LVEF reduction in breast cancer patients treated with doxorubicin

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Jennifer K. Lang ◽  
Badri Karthikeyan ◽  
Adolfo Quiñones-Lombraña ◽  
Rachael Hageman Blair ◽  
Amy P. Early ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Care Center ◽  
Left Ventricular ◽  
The Body ◽  
Left Ventricular Ejection ◽  
Breast Cancer Patients ◽  
Ventricular Ejection Fraction ◽  
Echocardiographic Parameters ◽  
The Impact

Abstract Background The CBR3 V244M single nucleotide polymorphism has been linked to the risk of anthracycline-related cardiomyopathy in survivors of childhood cancer. There have been limited prospective studies examining the impact of CBR3 V244M on the risk for anthracycline-related cardiotoxicity in adult cohorts. Objectives This study evaluated the presence of associations between CBR3 V244M genotype status and changes in echocardiographic parameters in breast cancer patients undergoing doxorubicin treatment. Methods We recruited 155 patients with breast cancer receiving treatment with doxorubicin (DOX) at Roswell Park Comprehensive Care Center (Buffalo, NY) to a prospective single arm observational pharmacogenetic study. Patients were genotyped for the CBR3 V244M variant. 92 patients received an echocardiogram at baseline (t0 month) and at 6 months (t6 months) of follow up after DOX treatment. Apical two-chamber and four-chamber echocardiographic images were used to calculate volumes and left ventricular ejection fraction (LVEF) using Simpson’s biplane rule by investigators blinded to all patient data. Volumetric indices were evaluated by normalizing the cardiac volumes to the body surface area (BSA). Results Breast cancer patients with CBR3 GG and AG genotypes both experienced a statistically significant reduction in LVEF at 6 months following initiation of DOX treatment for breast cancer compared with their pre-DOX baseline study. Patients homozygous for the CBR3 V244M G allele (CBR3 V244) exhibited a further statistically significant decrease in LVEF at 6 months following DOX therapy in comparison with patients with heterozygous AG genotype. We found no differences in age, pre-existing cardiac diseases associated with myocardial injury, cumulative DOX dose, or concurrent use of cardioprotective medication between CBR3 genotype groups. Conclusions CBR3 V244M genotype status is associated with changes in echocardiographic parameters suggestive of early anthracycline-related cardiomyopathy in subjects undergoing chemotherapy for breast cancer.

Dimensions of Cancer Locus of Control Scale as Predictors of Psychological Adjustment and Survival in Breast Cancer Patients

2005 ◽  
Vol 97 (3) ◽  
pp. 699-711 ◽  
Author(s):  
F. Cousson-Gélie ◽  
S. Irachabal ◽  
M. Bruchon-Schweitzer ◽  
J. M. Dilhuydy ◽  
F. Lakdja
Keyword(s):  
Breast Cancer ◽  
Body Image ◽  
Locus Of Control ◽  
Cancer Patients ◽  
Perceived Stress ◽  
Causal Attribution ◽  
Breast Cancer Patients ◽  
Control Scale ◽  
French Version ◽  
Religious Control

The Cancer Locus of Control Scale, to investigate specific beliefs of control in cancer patients, was validated previously with an English-speaking population. This study tested the construct and concurrent validity of a 17-item French version of the scale and explored its relations with psychological adjustment and with adaptation assessed two years later. In a sample of 157 women diagnosed with a first breast cancer, the French version was administered along with the Body Image Questionnaire, the State-Trait Anxiety Inventory, the Perceived Stress Scale, the Social Support Questionnaire, and the Ways of Coping Checklist. A factor analysis performed on scores identified the three original factors: internal causal attribution, control over the course of the illness, and religious control. Internal causal attribution was associated with high scores for state and trait anxiety, negative body image, emotion-focused coping, and problem-focused coping. Control over the course of the cancer was positively associated with scores on both problem- and emotion-focused coping. Religious control was negatively associated with perceived stress. Emotional adjustment and quality of life were assessed in 59 of the 157 breast cancer patients two years after diagnosis and original testing. Hierarchical regression analyses indicated that internal causal attribution significantly predicted 38.1% of the variance in rated state anxiety. None of the dimensions of the Cancer Locus of Control Scale predicted the duration of survival measured two years later in 75 of the 157 patients.

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