Quantitative SPECT/CT imaging using a commercial software

2016 ◽  
Vol 32 ◽  
pp. 102-103
Author(s):  
L. D'Ambrosio ◽  
L. Aloj ◽  
P. Chiaramida ◽  
V. Cerciello ◽  
P. Gaballo ◽  
...  
Keyword(s):  
Ct Imaging ◽  
Commercial Software ◽  
Quantitative Spect

Quantitative SPECT/CT imaging for medication-related osteonecrosis of the jaw: a preliminary study using volume-based parameters, comparison with chronic osteomyelitis

2019 ◽  
Vol 33 (10) ◽  
pp. 776-782 ◽  
Author(s):  
Ichiro Ogura ◽  
Eizaburo Kobayashi ◽  
Ken Nakahara ◽  
Kensuke Igarashi ◽  
Maiko Haga-Tsujimura ◽  
...  
Keyword(s):  
Chronic Osteomyelitis ◽  
Osteonecrosis Of The Jaw ◽  
Ct Imaging ◽  
Quantitative Spect ◽  
Preliminary Study

scholarly journals An alternative method for radioactivity measurement in quantitative bone SPECT/CT imaging

2021 ◽  
Vol 104 (3) ◽  
pp. 003685042110283
Author(s):  
Masaru Ishihara ◽  
Yasuaki Kato ◽  
Masahisa Onoguchi ◽  
Takayuki Shibutani
Keyword(s):  
Computed Tomography ◽  
Analytical Methods ◽  
Measurement Method ◽  
Ct Imaging ◽  
Emission Computed Tomography ◽  
Post Injection ◽  
Quantitative Spect ◽  
Quantitative Parameters ◽  
Alternative Method ◽  
Bone Spect

Bone scintigraphy with combined single-photon emission computed tomography (SPECT) and computed tomography (CT) has become widely used for the detection of bone metastases. However, calculation of the semi-quantitative standardized uptake value (SUV) requires measurement of the pre- and post-injection radioactivity of the radiopharmaceutical. This study aimed to compare measured and fixed input radioactivity values for quantitative SPECT/CT bone imaging to examine whether the fixed measurement method of radiopharmaceutical radioactivity could be used as an alternative method. Four different methods were used to quantify the Tc-99m hydroxymethylene diphosphonate input radioactivity: (A) measured pre- and post-injection radioactivity values; (B) measured pre-injection and fixed post-injection radioactivity values; (C) fixed pre-injection and measured post-injection radioactivity values; (D) fixed pre- and post-injection radioactivity values. All SPECT/CT acquisitions were analyzed using bone SPECT analysis software, and the semi-quantitative parameters (SUVpeak and SUVmean) were recorded and compared for each analytical method. Two semi-quantitative parameters showed significant differences between analytical methods A and B, A and D, and C and D. However, an additional subgroup analysis performed on patients whose median post-injection measured radioactivity value was <1.5 MBq showed no significant differences in parameters between all analytical methods. Measurement of the radiopharmaceutical radioactivity can be an alternative method because it reduces the volume of radioactivity post-injection. The simplified fixed measurement method of radiopharmaceutical radioactivity can be used as an alternative method in cases when measuring the radioactivity in quantitative bone SPECT/CT imaging is missed.

An automated voxelized dosimetry tool for radionuclide therapy based on serial quantitative SPECT/CT imaging

2013 ◽  
Vol 40 (11) ◽  
pp. 112503 ◽  
Author(s):  
Price A. Jackson ◽  
Jean-Mathieu Beauregard ◽  
Michael S. Hofman ◽  
Tomas Kron ◽  
Annette Hogg ◽  
...  
Keyword(s):  
Radionuclide Therapy ◽  
Ct Imaging ◽  
Quantitative Spect

scholarly journals Physical quantities useful for quality control of quantitative SPECT/CT imaging

2021 ◽  
Vol 24 (2) ◽  
pp. 93-98
Author(s):  
Sara Kurkowska ◽  
Bożena Birkenfeld ◽  
Hanna Piwowarska-Bilska
Keyword(s):  
Quality Control ◽  
Ct Imaging ◽  
Quantitative Spect ◽  
Physical Quantities

scholarly journals What validation tests can be done by the clinical medical physicist while waiting for the standardization of quantitative SPECT/CT imaging?

2020 ◽  
Author(s):  
Hanna Piwowarska-Bilska ◽  
Aleksandra Supińska ◽  
Bożena Birkenfeld
Keyword(s):  
Nuclear Medicine ◽  
Activity Concentration ◽  
Total Activity ◽  
Ct Imaging ◽  
Calibration Factor ◽  
Recovery Coefficient ◽  
Quantitative Spect ◽  
Gamma Cameras ◽  
Reconstruction Methods ◽  
Accuracy Of Measurements

Abstract Objective The aim of the study was to assess the accuracy of quantitative SPECT/CT imaging in a clinical setting and to compare test results from two nuclear medicine departments.Methods Phantom studies were carried out with two gamma cameras manufactured by GE Healthcare: Discovery NM/CT 670 and NM/CT 850, used in two nuclear medicine departments.Results The convergence of activity concentration recovery was validated for the two gamma cameras operating in two medical centres using a homogeneous 3D phantom. The comparison of results revealed a 5% difference in the calibration factor Bg. cal; 6% difference in COV, and a 0.6% difference in total activity deviation ∆Atot.Recovery coefficients (RCmax) for activity concentration in spheres of the anthropomorphic phantom was measured for different image reconstruction techniques. RCmax was in the range of 0.2-0.4 for the smallest sphere (ϕ10 mm), and 1.3-1.4 for the largest sphere (ϕ37 mm). Conversion factors for SUVmax and SUVmean for the gamma camera systems used were 0.99 and 1.13, respectively.Conclusions 1) Measurements taken in our study confirmed the clinical suitability of 5 parameters of image quality (Bg. cal- background calibration factor, ∆Atot- total activity deviation, COV- noise level estimation, QH- hot contrast, AM-accuracy of measurements or RC- recovery coefficient) for the validation of SPECT/CT system performance in terms of correct quantitative acquisitions of images. 2) This work shows that absolute SPECT/CT quantification is achievable in clinical nuclear medicine centers. Results variation of quantitative analyzes between centers is mainly related to the use of different reconstruction methods. 3) It is necessary to standardize the technique of measuring the SUV conversion factor obtained with different SPECT/CT scanners.

99mTc-DMSA renal cortical quantitative SPECT/CT imaging in diabetic patients: Feasibility and initial results

2018 ◽  
Vol 3 (2) ◽  
pp. 106
Author(s):  
Hebat-AllahA.A.R Askar ◽  
Hemat Abdel-Samea ◽  
YasserG Ali ◽  
MohamedA Mekkawy ◽  
WlaaA Mohamd
Keyword(s):  
Ct Imaging ◽  
Diabetic Patients ◽  
Quantitative Spect ◽  
Initial Results

Metal artifact reduction for improving quantitative SPECT/CT imaging

2021 ◽  
Vol 35 (3) ◽  
pp. 291-298
Author(s):  
Takahiro Konishi ◽  
Takayuki Shibutani ◽  
Koichi Okuda ◽  
Hiroto Yoneyama ◽  
Riku Moribe ◽  
...  
Keyword(s):  
Ct Imaging ◽  
Artifact Reduction ◽  
Metal Artifact ◽  
Metal Artifact Reduction ◽  
Quantitative Spect

scholarly journals Quantitative imaging of bone remodeling in patients with a unicompartmental joint unloading knee implant (ATLAS Knee System)—effect of metal artifacts on a SPECT-CT-based quantification

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Oliver S. Grosser ◽  
Marcus Klutzny ◽  
Heiko Wissel ◽  
Dennis Kupitz ◽  
Michael Finger ◽  
...  
Keyword(s):  
Activity Concentration ◽  
Ct Imaging ◽  
Slice Thickness ◽  
Systematic Bias ◽  
Ct Reconstruction ◽  
Reference Region ◽  
Metal Artifacts ◽  
System Effect ◽  
Quantitative Spect ◽  
X Ray

Abstract Background SPECT-CT using radiolabeled phosphonates is considered a standard for assessing bone metabolism (e.g., in patients with osteoarthritis of knee joints). However, SPECT can be influenced by metal artifacts in CT caused by endoprostheses affecting attenuation correction. The current study examined the effects of metal artifacts in CT of a specific endoprosthesis design on quantitative hybrid SPECT-CT imaging. The implant was positioned inside a phantom homogenously filled with activity (955 MBq 99mTc). CT imaging was performed for different X-ray tube currents (I = 10, 40, 125 mA) and table pitches (p = 0.562 and 1.375). X-ray tube voltage (U = 120 kVp) and primary collimation (16 × 0.625 mm) were kept constant for all scans. The CT reconstruction was performed with five different reconstruction kernels (slice thickness, 1.25 mm and 3.75 mm, each 512 × 512 matrix). Effects from metal artifacts were analyzed for different CT scans and reconstruction protocols. ROI analysis of CT and SPECT data was performed for two slice positions/volumes representing the typical locations for target structures relative to the prosthesis (e.g., femur and tibia). A reference region (homogenous activity concentration without influence from metal artifacts) was analyzed for comparison. Results Significant effects caused by CT metal artifacts on attenuation-corrected SPECT were observed for the different slice positions, reconstructed slice thicknesses of CT data, and pitch and CT-reconstruction kernels used (all, p < 0.0001). Based on the optimization, a set of three protocols was identified minimizing the effect of CT metal artifacts on SPECT data. Regarding the reference region, the activity concentration in the anatomically correlated volume was underestimated by 8.9–10.1%. A slight inhomogeneity of the reconstructed activity concentration was detected inside the regions with a median up to 0.81% (p < 0.0001). Using an X-ray tube current of 40 mA showed the best result, balancing quantification and CT exposure. Conclusion The results of this study demonstrate the need for the evaluation of SPECT-CT protocols in prosthesis imaging. Phantom experiments demonstrated the possibility for quantitative SPECT-CT of bone turnover in a specific prosthesis design. Meanwhile, a systematic bias caused by metal implants on quantitative SPECT data has to be considered.

1920: Variability in Size Measurement of Small Renal Masses on CT Imaging

2004 ◽  
Vol 171 (4S) ◽  
pp. 507-507 ◽  
Author(s):  
Sanoj P. Punnen ◽  
Massoom A. Haider ◽  
Fenella Moulding ◽  
Martin O'Malley ◽  
Gina Lockwood ◽  
...  
Keyword(s):  
Ct Imaging ◽  
Size Measurement ◽  
Small Renal Masses ◽  
Renal Masses
Sign in / Sign up

Export Citation Format

Share Document