Influence of the competing risk of death on estimates of disease recurrence in trials of adjuvant endocrine therapy for early-stage breast cancer: A secondary analysis of MA.27, MA.17 and MA.17R

2021 ◽  
Vol 149 ◽  
pp. 117-127
Author(s):  
Josee-Lyne Ethier ◽  
Geoffrey M. Anderson ◽  
Peter C. Austin ◽  
Mark Clemons ◽  
Wendy Parulekar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endocrine Therapy ◽  
Early Stage ◽  
Secondary Analysis ◽  
Disease Recurrence ◽  
Adjuvant Endocrine Therapy ◽  
Competing Risk ◽  
Early Stage Breast Cancer ◽  
Risk Of Death

Predicting nonadherence to adjuvant endocrine therapy in women with early stage breast cancer

2018 ◽  
Vol 27 (9) ◽  
pp. 2096-2103 ◽  
Author(s):  
Arden L. Corter ◽  
Reuben Broom ◽  
David Porter ◽  
Vernon Harvey ◽  
Michael Findlay
Keyword(s):  
Breast Cancer ◽  
Endocrine Therapy ◽  
Early Stage ◽  
Adjuvant Endocrine Therapy ◽  
Early Stage Breast Cancer

Evolution in the risk of adverse events of adjuvant endocrine therapy in postmenopausal women with early-stage breast cancer

2020 ◽  
Vol 182 (2) ◽  
pp. 259-266
Author(s):  
Daniel Reinhorn ◽  
Rinat Yerushalmi ◽  
Assaf Moore ◽  
Alexandra Desnoyers ◽  
Ramy R. Saleh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adverse Events ◽  
Postmenopausal Women ◽  
Endocrine Therapy ◽  
Early Stage ◽  
Adjuvant Endocrine Therapy ◽  
Early Stage Breast Cancer

Physician Survey of Timing of Adjuvant Endocrine Therapy Relative to Radiotherapy in Early Stage Breast Cancer Patients

2019 ◽  
Vol 19 (1) ◽  
pp. e40-e47 ◽  
Author(s):  
Sharon F. McGee ◽  
Lisa Vandermeer ◽  
Sasha Mazzarello ◽  
Marta Sienkiewicz ◽  
Carol Stober ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Endocrine Therapy ◽  
Early Stage ◽  
Adjuvant Endocrine Therapy ◽  
Early Stage Breast Cancer ◽  
Physician Survey ◽  
Breast Cancer Patients

Changes in adjuvant endocrine therapy over one year among postmenopausal women with early-stage breast cancer initiating aromatase inhibitors.

2012 ◽  
Vol 30 (34_suppl) ◽  
pp. 11-11
Author(s):  
Danielle Lindsay LaMorte ◽  
Katherine E. Hartmann ◽  
Vandana Gupta Abramson ◽  
Ingrid A. Mayer ◽  
Nancy Walker Peacock ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Postmenopausal Women ◽  
Endocrine Therapy ◽  
Aromatase Inhibitors ◽  
Clinical Decision Making ◽  
Early Stage ◽  
Adjuvant Endocrine Therapy ◽  
Early Stage Breast Cancer ◽  
Patient Reported ◽  
One Year

11 Background: Aromatase inhibitors (AIs) are standard of care for adjuvant endocrine therapy (AET) to prevent recurrence of early stage breast cancer in postmenopausal women. Previous AET adherence research has focused on the 25-96% adherence observed with, but more information is needed about AI adherence, especially regarding the role of arthralgia (joint pain or stiffness) in AET changes. Our objective was to understand AET changes within a year of AI initiation. Methods: We examined AET switching (either to another AI or to tamoxifen), overall changes in AET (including switching and temporary or permanent discontinuation), and physician- and patient-reported arthralgia, using data abstracted from medical records and self-administered surveys among 93 patients initiating AI. We conducted Chi-square and Wilcoxon univariate analyses. Results: Anastrazole was initially prescribed to 64 patients (69%), letrozole to 28 patients (30%), and exemestane to 1 patient. A year after AI initiation, 64 patients (69%) had no change in AET. Among the 29 patients (31%) who had an AET change, 14 switched to at least one other AI, 11 switched to tamoxifen, 9 temporarily discontinued AET, and 7 entirely discontinued AET (categories not mutually exclusive). Average time to first AET switch was 182.7 days. Average number of AET switches was 1.4. Arthralgia was the most common reason for AET changes, noted in the records of 19 patients (66% of those who changed AET). Patients who changed AET reported more severe arthralgia (median pain from 0-10 among 8 joint groups =1.4, interquartile range [IQR]=0.3-2.6) at week 12 than those who did not (median=0.3, IQR=0-1.1), p=0.03. A higher proportion (46%) of the 28 patients who initiated with letrozole changed AET due to arthralgia, compared with 20% of the 64 patients who initiated with anastrazole (p=0.01). Conclusions: A substantial proportion of women initiating AI change AET over one year. Arthralgia appears to play a key role in AET changes, particularly for letrozole as compared with anastrazole. More longitudinal patient-reported arthralgia data are needed to guide clinical decision making about AI initiation and AET changes.

Sign in / Sign up

Export Citation Format

Share Document