scholarly journals Epidemiology and clinical course of severe acute respiratory syndrome coronavirus 2 infection in cancer patients in the Veneto Oncology Network: The Rete Oncologica Veneta covID19 study

2021 ◽  
Vol 147 ◽  
pp. 120-127 ◽  
Author(s):  
Valentina Guarneri ◽  
Franco Bassan ◽  
Vittorina Zagonel ◽  
Michele Milella ◽  
Marta Zaninelli ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Cancer Patients ◽  
Clinical Course

scholarly journals A Timely Call to Arms: COVID-19, the Circadian Clock, and Critical Care

2021 ◽  
Vol 36 (1) ◽  
pp. 55-70
Author(s):  
Jeffrey Haspel ◽  
Minjee Kim ◽  
Phyllis Zee ◽  
Tanja Schwarzmeier ◽  
Sara Montagnese ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Human Physiology ◽  
Critical Care ◽  
Intensive Care ◽  
Severe Acute Respiratory Syndrome ◽  
Circadian Clock ◽  
Clinical Course ◽  
Disease Expression ◽  
Severe Manifestation ◽  
Novel Coronavirus

We currently find ourselves in the midst of a global coronavirus disease 2019 (COVID-19) pandemic, caused by the highly infectious novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we discuss aspects of SARS-CoV-2 biology and pathology and how these might interact with the circadian clock of the host. We further focus on the severe manifestation of the illness, leading to hospitalization in an intensive care unit. The most common severe complications of COVID-19 relate to clock-regulated human physiology. We speculate on how the pandemic might be used to gain insights on the circadian clock but, more importantly, on how knowledge of the circadian clock might be used to mitigate the disease expression and the clinical course of COVID-19.

Clinical Course of Breast Cancer Patients with Local-Regional Progression During Neoadjuvant Systemic Therapy

2021 ◽  
Author(s):  
Leisha C. Elmore ◽  
Henry M. Kuerer ◽  
Carlos H. Barcenas ◽  
Benjamin D. Smith ◽  
Makesha V. Miggins ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Systemic Therapy ◽  
Clinical Course ◽  
Breast Cancer Patients ◽  
Neoadjuvant Systemic Therapy

scholarly journals Serologic Concentrations of HER-2/neu in Breast Cancer Patients with Visceral Metastases Receiving Trastuzumab Therapy Predict the Clinical Course

2002 ◽  
Vol 48 (8) ◽  
pp. 1360-1362 ◽  
Author(s):  
Thomas Schöndorf ◽  
Markus Hoopmann ◽  
Mathias Warm ◽  
Rainer Neumann ◽  
Anke Thomas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Clinical Course ◽  
Breast Cancer Patients ◽  
Trastuzumab Therapy ◽  
Visceral Metastases ◽  
Her 2

scholarly journals Do checkpoint inhibitors compromise the cancer patients’ immunity and increase the vulnerability to COVID-19 infection?

Immunotherapy ◽  
2020 ◽  
Author(s):  
Joseph Kattan ◽  
Clarisse Kattan ◽  
Tarek Assi
Keyword(s):  
Cancer Therapy ◽  
Severe Acute Respiratory Syndrome ◽  
Cancer Patients ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Survival Outcomes ◽  
Toxicity Profile ◽  
Anti Cancer ◽  
Acquired Immunodeficiency ◽  
Improvement In Survival

The severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) has been declared a pandemic by the WHO that claimed the lives of thousands of people within a few months. Cancer patients represent a vulnerable population due to the acquired immunodeficiency associated with anti-cancer therapy. Immune checkpoint inhibitors have largely impacted the prognosis of a multitude of malignancies with significant improvement in survival outcomes and a different, tolerable toxicity profile. In this paper, we assess the safety of ICI administration in cancer patients during the coronavirus pandemic in order to guide the usage of these highly efficacious agents.

scholarly journals Effectiveness of steroid treatment for SARS-CoV-2 pneumonia with COP-like reaction: a case report

2020 ◽  
pp. 1-13
Author(s):  
Taehwa Kim ◽  
Eunjeong Son ◽  
Doosoo Jeon ◽  
Su Jin Lee ◽  
Seungjin Lim ◽  
...  
Keyword(s):  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Inflammatory Responses ◽  
Clinical Course ◽  
Steroid Treatment ◽  
Lung Damage ◽  
Organizing Pneumonia ◽  
Cryptogenic Organizing Pneumonia ◽  
Steroid Administration ◽  
Anti Inflammatory

Abstract Several studies on the treatment of coronavirus disease (COVID-19) are being conducted, and various drugs are being tried; however, the results have not been uniform. Steroids have been widely used in the treatment of COVID-19, but their effects are controversial. As immunosuppressive and anti-inflammatory agents, steroids are considered to reduce lung damage by regulating various inflammatory responses. We report a case of severe acute respiratory syndrome coronavirus-2 pneumonia manifesting as a cryptogenic organizing pneumonia-like reaction and discuss its treatment, clinical course, and favorable outcomes after steroid administration.

scholarly journals Clinical course of a critically ill patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

2020 ◽  
Vol 23 (4) ◽  
pp. 397-400 ◽  
Author(s):  
Nozomi Takahashi ◽  
Ryuzo Abe ◽  
Noriyuki Hattori ◽  
Yosuke Matsumura ◽  
Taku Oshima ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Critically Ill ◽  
Clinical Course ◽  
Critically Ill Patient

scholarly journals Diverse transitions in diabetes status during the clinical course of patients with resectable pancreatic cancer

2020 ◽  
Vol 50 (12) ◽  
pp. 1403-1411
Author(s):  
Ayako Shingyoji ◽  
Rintaro Mikata ◽  
Sadahisa Ogasawara ◽  
Yuko Kusakabe ◽  
Shin Yasui ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Distal Pancreatectomy ◽  
Cancer Patients ◽  
Clinical Course ◽  
Newly Diagnosed ◽  
Resectable Pancreatic Cancer ◽  
Diabetes Status ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes ◽  
Diabetes Resolution

Abstract Objective Pancreatic cancer and diabetes status have complex bilateral interactions; therefore, understanding their clinical features is essential for the clinical management of pancreatic cancer patients. We aimed to evaluate the diabetes status before diagnosis, after resection and until the time of recurrence in patients with resectable pancreatic cancer and to clarify the correlations among the clinical course of pancreatic cancer, operative procedure and diabetes status. Methods Between 2011 and 2016, we retrospectively identified 189 pancreatic cancer patients who underwent pancreatoduodenectomy or distal pancreatectomy at our institution. The entire clinical course of each patient was retrieved from the medical records, and the diabetes status in the longest possible duration was assessed. Results Among 115 pancreatic cancer patients who had normal glucose tolerance at the time of resection, 22 (19.1%) developed type 2 diabetes after resection. In a multivariate analysis, distal pancreatectomy was strongly associated with the development of postoperative diabetes. On the other hand, 74 pancreatic cancer patients had already been diagnosed with type 2 diabetes at the time of resection. During the follow-up period, 15 patients were noted to have diabetes resolution after resection; interestingly, the majority of these patients had newly diagnosed diabetes, which was defined as the diagnosis of diabetes within 3 months before resection. Moreover, newly diagnosed diabetes was an independent factor for diabetes resolution after resection. Conclusions In pancreatic cancer patients who underwent pancreatectomy, distal pancreatectomy was correlated with postoperative diabetes, and newly diagnosed diabetes had a high probability of resolution after resection.

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