Preclinical profile and phase I clinical trial of a novel androgen receptor antagonist GT0918 in castration-resistant prostate cancer

European Journal of Cancer ◽

10.1016/j.ejca.2020.04.013 ◽

2020 ◽

Vol 134 ◽

pp. 29-40 ◽

Cited By ~ 1

Author(s):

Tie Zhou ◽

Weidong Xu ◽

Wei Zhang ◽

Ye Sun ◽

Honghua Yan ◽

...

Keyword(s):

Prostate Cancer ◽

Clinical Trial ◽

Androgen Receptor ◽

Phase I ◽

Receptor Antagonist ◽

Phase I Clinical Trial ◽

Castration Resistant Prostate Cancer ◽

Androgen Receptor Antagonist ◽

Castration Resistant

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Abstract LB-203: Phase I/II study of the androgen receptor antagonist MDV3100 in castration-resistant prostate cancer

10.1158/1538-7445.am2008-lb-203 ◽

2008 ◽

Author(s):

Howard I. Scher ◽

Thomasz Beer ◽

Celestia S Higano ◽

Daniel C Danila ◽

Julia Shelkey ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Phase I ◽

Receptor Antagonist ◽

Castration Resistant Prostate Cancer ◽

Androgen Receptor Antagonist ◽

Castration Resistant

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Faculty Opinions recommendation of Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1118816.793494158 ◽

2014 ◽

Author(s):

Thomas Flaig

Keyword(s):

Prostate Cancer ◽

Clinical Trial ◽

Phase I ◽

Abiraterone Acetate ◽

Selective Inhibitor ◽

Phase I Clinical Trial ◽

Castration Resistant Prostate Cancer ◽

Castration Resistant

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Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC)

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c01563 ◽

2021 ◽

Vol 64 (2) ◽

pp. 909-924 ◽

Cited By ~ 1

Author(s):

Zhuming Zhang ◽

Peter J. Connolly ◽

Heng Keang Lim ◽

Vineet Pande ◽

Lieven Meerpoel ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Receptor Antagonist ◽

Clinical Stage ◽

Castration Resistant Prostate Cancer ◽

Wild Type ◽

Androgen Receptor Antagonist ◽

Castration Resistant

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Re: Phase I Clinical Trial of a Selective Inhibitor of CYP17, Abiraterone Acetate, Confirms that Castration-Resistant Prostate Cancer Commonly Remains Hormone Driven

European Urology ◽

10.1016/j.eururo.2008.09.035 ◽

2009 ◽

Vol 55 (1) ◽

pp. 248

Author(s):

Mario A. Eisenberger

Keyword(s):

Prostate Cancer ◽

Clinical Trial ◽

Phase I ◽

Abiraterone Acetate ◽

Selective Inhibitor ◽

Phase I Clinical Trial ◽

Castration Resistant Prostate Cancer ◽

Castration Resistant

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Phase 2 Study of the Safety and Antitumor Activity of Apalutamide (ARN-509), a Potent Androgen Receptor Antagonist, in the High-risk Nonmetastatic Castration-resistant Prostate Cancer Cohort

European Urology ◽

10.1016/j.eururo.2016.04.023 ◽

2016 ◽

Vol 70 (6) ◽

pp. 963-970 ◽

Cited By ~ 55

Author(s):

Matthew R. Smith ◽

Emmanuel S. Antonarakis ◽

Charles J. Ryan ◽

William R. Berry ◽

Neal D. Shore ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

High Risk ◽

Antitumor Activity ◽

Receptor Antagonist ◽

Phase 2 ◽

Castration Resistant Prostate Cancer ◽

Androgen Receptor Antagonist ◽

Castration Resistant ◽

Phase 2 Study

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Phospholipase C (PLC)ε Promotes Androgen Receptor Antagonist Resistance via the Bone Morphogenetic Protein (BMP)-6/SMAD Axis in a Castration-Resistant Prostate Cancer Cell Line

Medical Science Monitor ◽

10.12659/msm.915828 ◽

2019 ◽

Vol 25 ◽

pp. 4438-4449 ◽

Cited By ~ 1

Author(s):

Mengjuan Yuan ◽

Yingying Gao ◽

Luo Li ◽

Wei Sun ◽

Honglin Cheng ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Receptor Antagonist ◽

Prostate Cancer Cell ◽

Cancer Cell Line ◽

Prostate Cancer Cell Line ◽

Castration Resistant Prostate Cancer ◽

Androgen Receptor Antagonist ◽

Castration Resistant ◽

Morphogenetic Protein

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Acquired resistance to the second-generation androgen receptor antagonist enzalutamide in castration-resistant prostate cancer

Oncotarget ◽

10.18632/oncotarget.8456 ◽

2016 ◽

Vol 7 (18) ◽

pp. 26259-26274 ◽

Cited By ~ 38

Author(s):

Steven Kregel ◽

James L. Chen ◽

Westin Tom ◽

Venkatesh Krishnan ◽

Jacob Kach ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Receptor Antagonist ◽

Second Generation ◽

Acquired Resistance ◽

Castration Resistant Prostate Cancer ◽

Androgen Receptor Antagonist ◽

Castration Resistant

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Faculty Opinions recommendation of Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1118816.574906 ◽

2008 ◽

Author(s):

John Amory

Keyword(s):

Prostate Cancer ◽

Clinical Trial ◽

Phase I ◽

Abiraterone Acetate ◽

Selective Inhibitor ◽

Phase I Clinical Trial ◽

Castration Resistant Prostate Cancer ◽

Castration Resistant

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Re: Phase I Clinical Trial of a Selective Inhibitor of CYP17, Abiraterone Acetate, Confirms That Castration-Resistant Prostate Cancer Commonly Remains Hormone Driven

European Urology ◽

10.1016/j.eururo.2008.08.043 ◽

2008 ◽

Vol 54 (6) ◽

pp. 1438-1439 ◽

Cited By ~ 2

Author(s):

Jack A. Schalken

Keyword(s):

Prostate Cancer ◽

Clinical Trial ◽

Phase I ◽

Abiraterone Acetate ◽

Selective Inhibitor ◽

Phase I Clinical Trial ◽

Castration Resistant Prostate Cancer ◽

Castration Resistant

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PLCε knockdown overcomes drug resistance to androgen receptor antagonist in castration‐resistant prostate cancer by suppressing the wnt3a/β‐catenin pathway

Journal of Cellular Physiology ◽

10.1002/jcp.28195 ◽

2019 ◽

Vol 234 (9) ◽

pp. 15472-15486 ◽

Cited By ~ 1

Author(s):

Luo Li ◽

Zhongbo Du ◽

Yingying Gao ◽

Yu Tang ◽

Yanru Fan ◽

...

Keyword(s):

Prostate Cancer ◽

Drug Resistance ◽

Androgen Receptor ◽

Receptor Antagonist ◽

Castration Resistant Prostate Cancer ◽

Androgen Receptor Antagonist ◽

Castration Resistant

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