Pharmacokinetic/pharmacodynamic relationship of therapeutic monoclonal antibodies used in oncology: Part 1, monoclonal antibodies, antibody-drug conjugates and bispecific T-cell engagers

2020 ◽  
Vol 128 ◽  
pp. 107-118 ◽  
Author(s):  
Angelo Paci ◽  
Aude Desnoyer ◽  
Julia Delahousse ◽  
Louis Blondel ◽  
Christophe Maritaz ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
T Cell ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Relationship Of ◽  
Therapeutic Monoclonal Antibodies ◽  
Antibody Drug

scholarly journals Therapeutic Monoclonal Antibodies and Antibody Products: Current Practices and Development in Multiple Myeloma

Cancers ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 15 ◽  
Author(s):  
Francesca Bonello ◽  
Roberto Mina ◽  
Mario Boccadoro ◽  
Francesca Gay
Keyword(s):  
Multiple Myeloma ◽  
Clinical Trials ◽  
Monoclonal Antibodies ◽  
T Cell ◽  
Plasma Cells ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Promising Target ◽  
Therapeutic Monoclonal Antibodies ◽  
Antibody Drug

Immunotherapy is the latest innovation for the treatment of multiple myeloma (MM). Monoclonal antibodies (mAbs) entered the clinical practice and are under evaluation in clinical trials. MAbs can target highly selective and specific antigens on the cell surface of MM cells causing cell death (CD38 and CS1), convey specific cytotoxic drugs (antibody-drug conjugates), remove the breaks of the immune system (programmed death 1 (PD-1) and PD-ligand 1/2 (L1/L2) axis), or boost it against myeloma cells (bi-specific mAbs and T cell engagers). Two mAbs have been approved for the treatment of MM: the anti-CD38 daratumumab for newly-diagnosed and relapsed/refractory patients and the anti-CS1 elotuzumab in the relapse setting. These compounds are under investigation in clinical trials to explore their synergy with other anti-MM regimens, both in the front-line and relapse settings. Other antibodies targeting various antigens are under evaluation. B cell maturation antigens (BCMAs), selectively expressed on plasma cells, emerged as a promising target and several compounds targeting it have been developed. Encouraging results have been reported with antibody drug conjugates (e.g., GSK2857916) and bispecific T cell engagers (BiTEs®), including AMG420, which re-directs T cell-mediated cytotoxicity against MM cells. Here, we present an overview on mAbs currently approved for the treatment of MM and promising compounds under investigation.

Translational aspects of biologicals: monoclonal antibodies and antibody-drug conjugates as examples

2021 ◽  
pp. 329-350
Author(s):  
Sophia N. Karagiannis ◽  
Ricarda M. Hoffmann ◽  
Mano Nakamura ◽  
Silvia Crescioli ◽  
Heather J. Bax ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

scholarly journals Native and Denaturing MS Protein Deconvolution for Biopharma: Monoclonal Antibodies and Antibody–Drug Conjugates to Polydisperse Membrane Proteins and Beyond

2019 ◽  
Vol 91 (15) ◽  
pp. 9472-9480 ◽  
Author(s):  
Iain D. G. Campuzano ◽  
John H. Robinson ◽  
John O. Hui ◽  
Stone D.-H. Shi ◽  
Chawita Netirojjanakul ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Membrane Proteins ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug
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