Real-world efficacy and safety of lenvatinib: data from a compassionate use in the treatment of radioactive iodine-refractory differentiated thyroid cancer patients in Italy

2019 ◽  
Vol 118 ◽  
pp. 35-40 ◽  
Author(s):  
L.D. Locati ◽  
A. Piovesan ◽  
C. Durante ◽  
M. Bregni ◽  
M.G. Castagna ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Patients ◽  
Real World ◽  
Differentiated Thyroid Cancer ◽  
Radioactive Iodine ◽  
Efficacy And Safety ◽  
Compassionate Use

Clinico-social factors to choose radioactive iodine dose in differentiated thyroid cancer patients

2018 ◽  
Vol 39 (4) ◽  
pp. 283-289 ◽  
Author(s):  
Zeenat Jabin ◽  
Seong Young Kwon ◽  
Hee-Seung Bom ◽  
Yansong Lin ◽  
Ke Yang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Patients ◽  
Social Factors ◽  
Differentiated Thyroid Cancer ◽  
Radioactive Iodine ◽  
Iodine Dose

scholarly journals Redox parameters in blood of thyroid cancer patients after the radioiodine ablation

2017 ◽  
Vol 32 (4) ◽  
pp. 358-365
Author(s):  
Vera Spasojevic-Tisma ◽  
Milovan Matovic ◽  
Olgica Mihaljevic ◽  
Snezana Zivancevic-Simonovic ◽  
Marija Jeremic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Thyroid Cancer ◽  
Cancer Patients ◽  
Differentiated Thyroid Cancer ◽  
Radioactive Iodine ◽  
Reduced Glutathione ◽  
Thiobarbituric Acid ◽  
Oxygen Species ◽  
Thiobarbituric Acid Reactive Substances ◽  
Radioiodine Ablation

The radioactive iodine (131I) ablation is a well-accepted treatment modality for differentiated thyroid cancer patients. Unfortunately, the radiation induces the oxidative stress and damages cells and tissues, simultaneously activating the mechanisms of antioxidative defense. Since the mechanisms of those processes are not completely known, we wanted to examine the changes in the most important reactive oxygen species and antioxidative components, as well as their correlation and significance for lipid peroxidation. Our results showed that the level of thiobarbituric acid reactive substances was increased during the first 30 days after the radiotherapy. Among antioxidant components, superoxide dismutase was increased in the 3rd and 30th day; catalase in 7th and reduced glutathione in 3rd and 7th day after the radiotherapy. As regards the prooxidants, the reduction of hydrogen peroxide (H2O2) was recorded in 7th and 30th day, and superoxide anion radical (O?-) was unchanged after the exposure to 131I. These results indicate that differentiated thyroid cancer patients are under constant oxidative stress despite the observed increase in antioxidative and reduction in prooxidative parameters. The understanding of these early processes is important since their progress determines the latter effects of 131I therapy.

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