Long-term survival improvement in oesophageal cancer in the Netherlands

2018 ◽  
Vol 94 ◽  
pp. 138-147 ◽  
Author(s):  
M. van Putten ◽  
J. de Vos-Geelen ◽  
G.A.P. Nieuwenhuijzen ◽  
P.D. Siersema ◽  
V.E.P.P. Lemmens ◽  
...  
Keyword(s):  
The Netherlands ◽  
Oesophageal Cancer ◽  
Term Survival ◽  
Long Term Survival

Prognostic factors for medium- and long-term survival of esophageal cancer patients in the Netherlands

2013 ◽  
Vol 109 (5) ◽  
pp. 465-471 ◽  
Author(s):  
Pauline Bus ◽  
Valery E. Lemmens ◽  
Martijn G. van Oijen ◽  
Geert-Jan Creemers ◽  
Grard A. Nieuwenhuijzen ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Prognostic Factors ◽  
The Netherlands ◽  
Cancer Patients ◽  
Term Survival ◽  
Long Term Survival

scholarly journals P-OGC06 The effect of surgical complications on long-term prognosis following oesophagectomy for oesophageal cancer

2021 ◽  
Vol 108 (Supplement_9) ◽  
Author(s):  
Anna Broadbent ◽  
Saqib Rahman ◽  
Ben Grace ◽  
Robert Walker ◽  
Fergus Noble ◽  
...  
Keyword(s):  
Critical Care ◽  
Median Survival ◽  
Oesophageal Cancer ◽  
Population Attributable Fraction ◽  
Oesophageal Adenocarcinoma ◽  
Term Survival ◽  
Long Term Survival ◽  
Major Complications ◽  
Long Term Prognosis

Abstract Background Globally, oesophageal cancer incidence continues to increase. In recent years, surgical and oncological advancements have increased survival rates. Despite this, survival remains <50% at five-years for patients treated with curative oesophagectomy. Previous data has suggested post-operative complications may play a role in long-term increased mortality in oesophageal cancer patients. This study aimed to examine the effect of adverse in-hospital events following oesophagectomy on the long-term prognosis for oesophageal cancer, including assessing the effect of cumulative complication burden using data from a single high-volume academic unit in the UK.  Methods Retrospective analysis of patients undergoing oesophagectomy for oesophageal adenocarcinoma or squamous cell carcinoma was performed to assess the relationship between in-hospital events and long-term survival. Analysis was limited to patients who survived to 90 days post-oesophagectomy (n = 380). Complications were graded according to the Clavien-Dindo (CD) classification and the Comprehensive Complication Index (CCI). Survival was estimated using Kaplan Meier survival curves and multivariate cox-regression, adjusting for variables known to influence survival. The absolute magnitude of effect of complications on survival was assessed using the risk-adjusted population attributable fraction (PAF), which estimates the percentage improvement in survival if specified complications were removed. Results Complications occurred in 251 patients (66.1%). ≥CD3a complications (HR1.65, 95%CI 1.15-2.38, p < 0.010) and unplanned critical care admissions (HR2.24, 95%CI 1.45-3.46, p < 0.001) were independently associated with worse prognosis whereas pulmonary complications and anastomotic leak were not. A CCI >30 was the optimum cut-point for OS (HR1.94, 95%CI 1.36-2.78, p < 0.001), and after weighting to remove confounding bias median survival was shorter with CCI>30 (28vs72 months, p < 0.001).  There was no difference in median survival when CCI>30 occurred from major or multiple minor complications (31 vs 21 months, p = 0.096). The risk adjusted PAF for CCI>30 was 8.5% (95%CI 3.6-13.1%). Conclusions Long-term survival following oesophagectomy for oesophageal cancer is significantly affected by major complications and unplanned critical care admissions. The cumulative effect of multiple post-operative minor complications is comparable to the effect of major complications on long-term survival from oesophageal cancer, and cause a substantial number of potentially preventable deaths, even in patients who survive to discharge. 

scholarly journals Impact of hospital volume on long-term survival after resection for oesophageal cancer: a population-based study in Taiwan†

2014 ◽  
Vol 46 (6) ◽  
pp. e127-e135 ◽  
Author(s):  
Po-Kuei Hsu ◽  
Hui-Shan Chen ◽  
Shiao-Chi Wu ◽  
Bing-Yen Wang ◽  
Chao-Yu Liu ◽  
...  
Keyword(s):  
Oesophageal Cancer ◽  
Hospital Volume ◽  
Population Based ◽  
Term Survival ◽  
Population Based Study ◽  
Long Term Survival

scholarly journals Long-term survival improvement in esophageal cancer in the Netherlands

2017 ◽  
Vol 28 ◽  
pp. iii13
Author(s):  
Margreet van Putten ◽  
Judith de Vos-Geelen ◽  
Grard Nieuwenhuijzen ◽  
Peter Siersema ◽  
Valery Lemmens ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
The Netherlands ◽  
Term Survival ◽  
Long Term Survival

scholarly journals Long term survival in gastro-oesophageal cancer

Gut ◽  
2011 ◽  
Vol 60 (Suppl 1) ◽  
pp. A177-A178
Author(s):  
S. F. Neong ◽  
J. Deacon ◽  
I. R. Sargeant ◽  
D. L. Morris
Keyword(s):  
Oesophageal Cancer ◽  
Term Survival ◽  
Long Term Survival
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