AB680, a potent and selective CD73 small molecule inhibitor, reverses the AMP/adenosine-mediated impairment of immune effector cell activation by immune checkpoint inhibitors

2018 ◽  
Vol 92 ◽  
pp. S14 ◽  
Author(s):  
U. Schindler ◽  
A. Becker ◽  
K. Lawson ◽  
L. Jin ◽  
J. Jeffrey ◽  
...  
Keyword(s):  
Small Molecule ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Cell Activation ◽  
Effector Cell ◽  
Checkpoint Inhibitors ◽  
Small Molecule Inhibitor ◽  
Immune Effector Cell ◽  
Immune Effector ◽  
Molecule Inhibitor

Abstract B192: CD56 participation in immune effector cell activation and tumor cell eradication: A role for interleukin-15

2019 ◽  
Author(s):  
Heleen H. Van Acker ◽  
Maarten Versteven ◽  
Hans De Reu ◽  
Peter Ponsaerts ◽  
Zwi N Berneman ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Activation ◽  
Effector Cell ◽  
Immune Effector Cell ◽  
Immune Effector ◽  
Interleukin 15

Conjugation of biphenyl groups with poly(ethylene glycol) to enhance inhibitory effects on the PD-1/PD-L1 immune checkpoint interaction

2020 ◽  
Vol 8 (44) ◽  
pp. 10162-10171
Author(s):  
Eun-Hye Kim ◽  
Boyang Ning ◽  
Masuki Kawamoto ◽  
Hideyuki Miyatake ◽  
Eiry Kobatake ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Small Molecule ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Inhibitory Effect ◽  
Inhibitory Effects ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Multivalent Effect

Inhibitory effect of small molecule immune checkpoint inhibitors on the PD-1/PD-L1 immune checkpoint interaction was enhanced by the multivalent effect through the conjugation of branched PEG.

Tu1729 Suppression of Hepatic Stellate Cell Activation by HJC0123, a Novel Small-Molecule Inhibitor of STAT3

2016 ◽  
Vol 150 (4) ◽  
pp. S1259
Author(s):  
Fredrick Bohanon ◽  
Xiaofu Wang ◽  
Omar Nunez Lopez ◽  
Sadhashiva Vasudevan ◽  
Haijun Chen ◽  
...  
Keyword(s):  
Small Molecule ◽  
Hepatic Stellate Cell ◽  
Cell Activation ◽  
Stellate Cell ◽  
Small Molecule Inhibitor ◽  
Hepatic Stellate Cell Activation ◽  
Molecule Inhibitor
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