In vitro culture of tumor infiltrating lymphocytes for adoptive immunotherapy in breast cancer patients

2018 ◽  
Vol 92 ◽  
pp. S9-S10
Author(s):  
S. Seber ◽  
T. Yetisyigit ◽  
B. Turgut ◽  
S. Bulus ◽  
S. Ozkan Gürdal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
In Vitro Culture ◽  
Cancer Patients ◽  
Adoptive Immunotherapy ◽  
Tumor Infiltrating Lymphocytes ◽  
Breast Cancer Patients ◽  
Infiltrating Lymphocytes

scholarly journals Stromal Tumor Infiltrating Lymphocytes (sTILs) as a putative prognostic marker to identify a responsive subset of TNBC in an Indian Breast Cancer Cohort.

2020 ◽  
Author(s):  
Pooja Vaid ◽  
Anirudha Puntambekar ◽  
Rituja Banale ◽  
Ruhi Reddy ◽  
Rohini Unde ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Tumor Infiltrating Lymphocytes ◽  
Response To Therapy ◽  
Stromal Tumor ◽  
Breast Cancer Patients ◽  
Infiltrating Lymphocytes ◽  
Disease Free

Objectives Prognostic significance of stromal tumor infiltrating lymphocytes; sTILs is evaluated to identify a responsive subset of TNBC in an Indian cohort of breast cancer patients. Methods A retrospective cohort of breast cancer patients from a single onco-surgeon breast cancer clinic treated with uniform treatment strategy across is evaluated for sTILs. FFPE tissue of primary tumor of invasive breast carcinoma are collected with ethical approvals. Tumor sections blinded for subtypes are stained with H&E and scored for sTILs by a pathologist following Immuno-Oncology TILs working groups scoring guidelines. Results Analysis of 144 primary breast tumors for sTILs scores re-enforces significantly higher infiltration in TNBC tumors than HER2+ve and ER+ve tumors. Higher sTILs scores co-relate with gradually incremental pathological response to therapy specifically in TNBC subset and with better disease-free survival outcomes. Within TNBC, older and post-menopausal patients harbor higher scores of sTILs. Conclusion Despite a small cohort of breast cancer patients, TNBC subtype reflected significantly higher scores of sTILs with better response to therapy and disease-free outcomes as compared to other breast cancer subtypes. A larger number of breast cancer patients from an Indian cohort will strengthen the findings to establish sTILs as a marker to identify a responsive subset of TNBC.

scholarly journals Tumor Infiltrating Lymphocytes and NHERF1 Impact on Prognosis of Breast Cancer Patients

2020 ◽  
Vol 13 (2) ◽  
pp. 186-192 ◽  
Author(s):  
Laura Schirosi ◽  
Concetta Saponaro ◽  
Francesco Giotta ◽  
Ondina Popescu ◽  
Maria Irene Pastena ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Tumor Infiltrating Lymphocytes ◽  
Breast Cancer Patients ◽  
Infiltrating Lymphocytes

HER2-amplification level and tumor-infiltrating lymphocytes in breast cancer patients treated with neoadjuvant trastuzumab.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 596-596
Author(s):  
Cristina Masini ◽  
Giancarlo Bisagni ◽  
Moira Ragazzi ◽  
Alessandra Bisagni ◽  
Katiuscia Dallaglio ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Tumor Infiltrating Lymphocytes ◽  
Breast Cancer Patients ◽  
Her2 Amplification ◽  
Infiltrating Lymphocytes
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