Single-nucleotide polymorphism in the 5-α-reductase gene ( SRD5A2 ) is associated with increased prevalence of metabolic syndrome in chemotherapy-treated testicular cancer survivors

2016 ◽  
Vol 54 ◽  
pp. 104-111 ◽  
Author(s):  
Hink Boer ◽  
Nico-Derk L. Westerink ◽  
Renske Altena ◽  
Janine Nuver ◽  
D.A. Janneke Dijck-Brouwer ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Single Nucleotide Polymorphism ◽  
Testicular Cancer ◽  
Cancer Survivors ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Reductase Gene ◽  
Testicular Cancer Survivors

Estrogen receptor α single nucleotide polymorphism modifies the risk of azoospermia in childhood cancer survivors

2011 ◽  
Vol 21 (5) ◽  
pp. 263-269 ◽  
Author(s):  
Patrik Romerius ◽  
Aleksander Giwercman ◽  
Christian Moëll ◽  
Thomas Relander ◽  
Eva Cavallin-Ståhl ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Estrogen Receptor ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Estrogen Receptor Α ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

Development of a ligation-based impedimetric DNA sensor for single-nucleotide polymorphism associated with metabolic syndrome

2006 ◽  
Vol 51 (28) ◽  
pp. 6367-6372 ◽  
Author(s):  
Yoshinori Akagi ◽  
Megumi Makimura ◽  
Yoshiyuki Yokoyama ◽  
Masaki Fukazawa ◽  
Satoshi Fujiki ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Single Nucleotide Polymorphism ◽  
Dna Sensor ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

scholarly journals Pathogenetic significance of C774T single nucleotide polymorphism of the endothelial NO synthase gene in the development of metabolic syndrome

2016 ◽  
Vol 62 (4) ◽  
pp. 447-452 ◽  
Author(s):  
N.S. Fattakhov ◽  
M.A. Vasilenko ◽  
D.A. Skuratovskaia ◽  
D.I. Kulikov ◽  
E.V. Kirienkova ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Metabolic Syndrome ◽  
Single Nucleotide Polymorphism ◽  
Serum Levels ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Nos3 Gene ◽  
Kaliningrad Region ◽  
The Relationship

The relationship between nitric oxide production and metabolic disorders and the role of endothelial nitric oxide synthase (eNOS or NOS3) in metabolic syndrome (MS) remain poorly understood and need deeper investigation. In this context the role of the NOS3 gene in pathogenesis of MS is of special interest. The aim of the study was to investigate association of NOS3 single nucleotide polymorphism C774T with risk of MS in the Slavic population of the Kaliningrad region and the relationship of this polymorphic variant with some parameters of endothelial dysfunction. The study included 128 patients (48 men and 80 women aged from 36 to 52 years) with MS. The control group consisted of 126 healthy volunteers (60 men and 66 women aged from 30 to 40 years). Genotyping was performed by real-time PCR. Serum nitrite levels were determined spectrophotometrically by the Griess method. Serum levels of endothelin-1 and eNOS were evaluated by ELISA. The study has shown association of T allele (OR=2.06; p=0.0004; CI: 1.38-3.08) and CT genotype (OR=1.97; p=0.014; CI: 1.14-3.40 ) C774T polymorphism of the NOS3 gene with risk of MS in the Slavic population of the Kaliningrad region. Allele C (OR=0.48; p=0.0004; CI: 0.32-0.72) and homozygous CC genotype (OR=0.41; p=0.001; CI: 0.24-0,69) C774T polymorphism of the NOS3 gene were associated with reduced risk of the development of MS. Significant differences in serum levels of eNOS and endothelin-1 depended on the CT and TT genotypes of C774T polymorphism of the NOS3 gene in MS.

scholarly journals Reproductive hormones and metabolic syndrome in 24 testicular cancer survivors and their biological brothers

Andrology ◽  
2017 ◽  
Vol 5 (4) ◽  
pp. 718-724 ◽  
Author(s):  
M. Bandak ◽  
N. Jørgensen ◽  
A. Juul ◽  
J. Lauritsen ◽  
M. G. G. Kier ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Testicular Cancer ◽  
Cancer Survivors ◽  
Reproductive Hormones ◽  
Testicular Cancer Survivors
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