P0105 Flavonoid fraction of Citrus reticulata juice inhibits both proliferation and migration of anaplastic thyroid carcinoma cells

2015 ◽  
Vol 51 ◽  
pp. e21
Author(s):  
M. Celano ◽  
V. Maggisano ◽  
R.F. De Rose ◽  
S. Bulotta ◽  
J. Maiuolo ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Anaplastic Thyroid Carcinoma ◽  
Carcinoma Cells ◽  
Citrus Reticulata ◽  
Flavonoid Fraction ◽  
And Migration ◽  
Proliferation And Migration

Flavonoid Fraction of Citrus Reticulata Juice Reduces Proliferation and Migration of Anaplastic Thyroid Carcinoma Cells

2015 ◽  
Vol 67 (7) ◽  
pp. 1183-1190 ◽  
Author(s):  
Marilena Celano ◽  
Valentina Maggisano ◽  
Roberta Francesca De Rose ◽  
Stefania Bulotta ◽  
Jessica Maiuolo ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Anaplastic Thyroid Carcinoma ◽  
Carcinoma Cells ◽  
Citrus Reticulata ◽  
Flavonoid Fraction ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals LPAR5 Promotes Thyroid Carcinoma Cells Proliferation and Migration by Activating Class IA PI3K Catalytic Subunit p110β

2021 ◽  
Author(s):  
Wei‐Jun Zhao ◽  
Liu‐Lian Zhu ◽  
Wei‐Qiang Yang ◽  
Shuai‐Jun Xu ◽  
Jie Chen ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Carcinoma Cells ◽  
Catalytic Subunit ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals α-Enolase Lies Downstream of mTOR/HIF1α and Promotes Thyroid Carcinoma Progression by Regulating CST1

2021 ◽  
Vol 9 ◽  
Author(s):  
Yang Liu ◽  
Lida Liao ◽  
Changming An ◽  
Xiaolei Wang ◽  
Zhengjiang Li ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Theoretical Foundation ◽  
Carcinoma Cell ◽  
Carcinoma Cells ◽  
Novel Therapy ◽  
And Migration ◽  
Therapy Strategies ◽  
Thyroid Carcinoma Cell ◽  
Proliferation And Migration

Novel therapy strategies are crucial for thyroid carcinoma treatment. It is increasingly important to clarify the mechanism of thyroid carcinoma progression. Several studies demonstrate that α-Enolase (ENO1) participates in cancer development; nevertheless, the role of ENO1 in thyroid carcinoma progression remains unclear. In the present study, we found that the expression of ENO1 was upregulated in thyroid carcinoma samples. Proliferation and migration of thyroid carcinoma cells were suppressed by depletion of ENO1; conversely, ENO1 overexpression promoted thyroid carcinoma cell growth and invasion. To elucidate the mechanisms, we found that the hypoxia-related mTOR/HIF1 pathway regulated ENO1 expression. ENO1 regulated the expression of CST1; knockdown of CST1 reversed the tumorigenicity enhanced by ENO1 overexpression. Taken together, our findings provide a theoretical foundation for thyroid carcinoma treatment.

Evaluation of E-Cadherin and β-Catenin Immunoreactivity for Determining Undifferentiated Cells in Anaplastic Thyroid Carcinoma

Pathobiology ◽  
2021 ◽  
pp. 1-8
Author(s):  
Risa Kanematsu ◽  
Mitsuyoshi Hirokawa ◽  
Aki Tanaka ◽  
Ayana Suzuki ◽  
Miyoko Higuchi ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Thyroid Carcinoma ◽  
Undifferentiated Carcinoma ◽  
Anaplastic Thyroid Carcinoma ◽  
Carcinoma Cells ◽  
Membrane Expression ◽  
Thyroid Carcinomas ◽  
Nuclear Expression ◽  
Thyroid Transcription Factor 1 ◽  
E Cadherin

<b><i>Introduction:</i></b> An immunohistochemical study has occasionally been performed to diagnose anaplastic thyroid carcinoma (ATC). However, antibodies to confirm the undifferentiated nature of ATC have not yet been evaluated. The aim of this study was to evaluate E-cadherin and β-catenin expressions in immunoreactivity to determine undifferentiated carcinoma cells in the diagnosis of ATC. <b><i>Methods:</i></b> We immunohistochemically examined 29 ATCs, 30 poorly differentiated thyroid carcinomas (PDTCs), 22 well-differentiated thyroid carcinomas (WDTCs), and 3 squamous cell carcinomas. Antibodies for thyroid transcription factor-1 (TTF-1), paired-box gene 8 (PAX8), β-catenin, and E-cadherin were used. <b><i>Results:</i></b> All WDTCs tested positive for TTF-1, PAX8, and E-cadherin. The positive rates of TTF-1, PAX8, and E-cadherin were 93.3, 93.3, and 100%, respectively, in PDTCs and 17.2, 51.7, and 10.3%, respectively, in ATCs. WDTC expressed the lateral cell membrane staining for β-catenin and E-cadherin, whereas PDTC showed circumferential cell membranous expression (fishnet pattern). β-catenin cell membrane expression in ATCs is lost or discontinuous. Carcinoma cells with β-catenin nuclear expression without cell membranous expression were scattered in 72.4% of ATCs but were not observed in the other carcinomas. <b><i>Conclusion:</i></b> We propose 3 immunohistochemical findings to determine undifferentiated carcinoma cells in the diagnosis of ATC: (1) β-catenin nuclear expression with no or reduced cell membranous expression, (2) the loss or discontinuous pattern of E-cadherin expression, and (3) the loss of PAX8 nuclear expression.

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